公开(公告)号：KR101410904B1

公开(公告)日：2014-07-02

申请号：KR1020130052575

申请日：2013-05-09

Applicant: 재단법인 의약바이오컨버젼스연구단

Inventor： 김성훈 ,  권혁상 ,  한정민

IPC: G01N33/68 ,  G01N33/574 ,  A61K39/395 ,  A61P35/00

Abstract: The present invention relates to a method for screening an anticancer medicine and an inflammatory disease treatment medicine and, more specifically, to an inflammatory disease treatment medicine/anticancer medicine screening method which includes the steps of: forming a contact with a part or whole of an ARS-interacting multi-functional protein 1 (AIMP1), a CD23, and candidate agents; and selecting a candidate agent which hinders an interaction between the part or whole of the AIMP1 and the CD23. The method of the present invention is efficient to select an inflammatory disease treatment medicine which suppresses an AIMP1 medium inflammatory cytokine; and an anticancer medicine which increases the level of a free AIMP1 having an anticancer activity by suppressing the cell attachment of the AIMP1.

Abstract translation: 本发明涉及一种抗癌药物和炎性疾病治疗药物的筛选方法，更具体地，涉及炎症性疾病治疗药物/抗癌药物筛选方法，其包括以下步骤：与部分或全部的 ARS相互作用的多功能蛋白1（AIMP1），CD23和候选试剂; 并选择阻碍AIMP1的一部分或全部与CD23之间的相互作用的候选代理。 本发明的方法是有效地选择抑制AIMP1介质炎性细胞因子的炎性疾病治疗药物; 以及通过抑制AIMP1的细胞附着而增加具有抗癌活性的游离AIMP1的水平的抗癌药。