公开(公告)号：KR1020120091744A

公开(公告)日：2012-08-20

申请号：KR1020110011713

申请日：2011-02-10

Applicant: 전남대학교병원

Inventor： 배인호 ,  조은정 ,  박인규 ,  김동곤 ,  정명호 ,  김주한 ,  한동근 ,  조상기 ,  이해신

IPC: A61F2/82 ,  A61L27/28 ,  A61L27/54 ,  A61K31/727

CPC classification number: A61F2/82 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/00976 ,  A61L31/10 ,  A61L31/16

Abstract: PURPOSE: A method for coating heparin on the surface of a stent is provided to improve the stability heparin on the surface of a stent based on the chemical bond of dopamine and the heparin. CONSTITUTION: A method for coating heparin on the surface of a stent includes the following: heparin and dopamine are synthesized, and a solution with the dissolved synthesized product is prepared; and the solution is applied on the surface of a metal-based stent such that the heparin is coated on the surface of the stent. The molar ratio of the heparin and the dopamine is 1:1.2-1.5. The coating process is based on an immersing process or a spraying process. The stent is immersed in the synthesized product dissolved solution, or the synthesized product dissolved solution is sprayed on the stent.

Abstract translation: 目的：提供一种在支架表面涂覆肝素的方法，以改善基于多巴胺和肝素化学键的支架表面稳定性肝素。 构成：在支架表面涂覆肝素的方法包括以下：合成肝素和多巴胺，制备溶解合成产物的溶液; 并将溶液施加到金属基支架的表面上，使得肝素被涂覆在支架的表面上。 肝素和多巴胺的摩尔比为1:1.2-1.5。 涂覆工艺基于浸渍工艺或喷涂工艺。 将支架浸入合成产物溶解溶液中，或将合成产物溶解的溶液喷涂在支架上。