公开(公告)号：KR100954887B1

公开(公告)日：2010-04-28

申请号：KR1020090051422

申请日：2009-06-10

Applicant: 전남대학교산학협력단

Inventor： 이제중 ,  마사오다케이 ,  우메야마아케미 ,  김규식

IPC: C12N5/0784

CPC classification number: C12N5/064

Abstract: PURPOSE: Matured dendritic cells by uncarinic acid C are provided to enhance the differentiation of nave T cells to Th1 cells and to induce specific reaction. CONSTITUTION: A mutured dendritic cell is obtained by adding uncarinic acid C to immature dendritic cells and culturing. A composition for immunotherapy contains dendritic cells, T cells differentiated therefrom, or cytokine produced thereby. The uncarinic acid C is isolated from Uncaria rhynchophylla. A method for producing the matured dendritic cells comprises: a step of adding uncarinic acid C to immature dendritic cells by intravenous or hypodermic infection, and a step of culturing the dendritic cells.

Abstract translation: 目的：提供通过脱羧酸C的成熟树突状细胞，以增强纳瓦T细胞与Th1细胞的分化并诱导特异性反应。 构成：通过向未成熟的树突状细胞中加入非卡洛芬酸C并进行培养获得了一种突变的树突状细胞。 用于免疫治疗的组合物包含树突状细胞，从其分化的T细胞或由此产生的细胞因子。 脱羧酸C分离自钩藤草（Uncaria rhynchophylla）。 一种生产成熟树突状细胞的方法包括：通过静脉内或皮下感染向未成熟树突细胞中添加非卡里酸C的步骤和培养树突状细胞的步骤。