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公开(公告)号：KR1020110130253A
公开(公告)日：2011-12-05
申请号：KR1020100049809
申请日：2010-05-27
Applicant: 전남대학교산학협력단
IPC: C07F9/54 , C07C211/64 , A61K51/04 , A61K101/02
CPC classification number: C07F9/5442 , A61K51/04 , A61K51/1282
Abstract: PURPOSE: A method for manufacturing a radiopharmacy for mitochondria image and a precursor thereof are provided to simply obtain the radiopharmacy with high yield. CONSTITUTION: A method for manufacturing a radiopharmacy for microchondria image comprises a step of substituting X^1 substituent of a compound of chemical formula 1 or salt thereof with radioactive isotope of 18F, 76Br or 123I. The E is phosphorus or nitrogen. The radiopharmacy is 18F-fluoromethyl triphenyl phosphonium, 18F-2-fluoroethyl triphenyl phosphonium, 18F-3-fluoropropyl triphenyl phosphonium, 18F-4-fluorobutyl triphenyl phosphonium, 18F-5-fluoropentyl triphenyl phosphonium, 18F-6-fluorohexyl triphenyl phosphonium, 18F-7-fluoroheptyl phenyl phosphonium, or 18F-8-fluorooctyl triphenyl phosphonium.
Abstract translation: 目的：提供一种制造线粒体图像放射性药物的方法及其前体，以简单地以高产率获得放射性药物。 构成：用于制造用于微型软骨细胞图像的放射性药物的方法包括用放射性同位素18F，76Br或123I替代化学式1化合物或其盐的X 1取代基的步骤。 E是磷或氮。 放射性药物是18F-氟甲基三苯基鏻，18F-2-氟乙基三苯基鏻，18F-3-氟丙基三苯基鏻，18F-4-氟丁基三苯基鏻，18F-5-氟戊基三苯基鏻，18F-6-氟己基三苯基鏻18F -7-氟庚基苯基鏻或18F-8-氟辛基三苯基鏻。
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公开(公告)号：KR101172157B1
公开(公告)日：2012-08-07
申请号：KR1020100049809
申请日：2010-05-27
Applicant: 전남대학교산학협력단
IPC: C07F9/54 , C07C211/64 , A61K51/04 , A61K101/02
Abstract: 본 발명은 방사성 약물의 제조 방법 및 그 전구체에 대한 것이다. 본 발명의 제조 방법은 높은 수율로 방사성 약물을 제조할 수 있을 뿐 아니라 안정적인 반응물을 이용함으로써 간편하고 높은 수율로 방사성 약물을 제조할 수 있게 한다.
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