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公开(公告)号：KR101495847B1
公开(公告)日：2015-03-11
申请号：KR1020130150894
申请日：2013-12-05
Applicant: 전북대학교산학협력단
CPC classification number: C08G63/672 , A61K9/5031 , A61K47/34
Abstract: 본 발명은 PVO(poly(vanillin oxalate)) 공중합체, 상기 PVO 공중합체를 포함하는 PVO 미립구, 상기 PVO 미립구를 포함하는 약물전달체, 항산화용, 항염증용, 암세포 전이 억제용 조성물 및, 허혈성 질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 PVO 미립구는 독성이 없으며, 우수한 생체적합성을 가지고 있고, 염증 조직 및 세포에서 나타나는 생리적 조건인 낮은 pH 및 과산화수소에 민감하게 반응하여 바닐린을 방출함으로써 뛰어난 항산화 및 항염증 효과를 가지고 있으며, 암세포 전이 억제 활성 및 허혈성 질환에 대한 우수한 치료 효과를 가지고 있어, 다양한 의약 분야에서 유용하게 이용될 수 있다.
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公开(公告)号：KR1020130123882A
公开(公告)日：2013-11-13
申请号：KR1020120047361
申请日：2012-05-04
Applicant: 전북대학교산학협력단
IPC: C08L101/16 , C08K5/07 , A61K47/30 , A61P29/00
Abstract: The present invention relates to a polymer scaffold comprising vanillin and a manufacturing method thereof. The present invention is compatible for biodegrading, derives cell growth, accelerates basic growth, and continuously emits vanillin for obtaining anti-inflammatory and antioxidant properties, thereby being useful as a biodegradable material, drug delivery material, and a pharmaceutical composition.
Abstract translation: 本发明涉及包含香草醛的聚合物支架及其制造方法。 本发明可用于生物降解，促进细胞生长，加速碱性生长，并且连续地发出香草醛以获得抗炎和抗氧化性质，从而可用作可生物降解的材料，药物递送材料和药物组合物。
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公开(公告)号：KR1020140073452A
公开(公告)日：2014-06-16
申请号：KR1020130150894
申请日：2013-12-05
Applicant: 전북대학교산학협력단
CPC classification number: C08G63/672 , A61K9/5031 , A61K47/34 , C08G61/12 , A61K47/30 , A61K47/50 , C08G63/02
Abstract: The present invention relates to a poly(vanillin oxalate) (PVO) copolymer, a PVO microsphere including the PVO copolymer, a drug carrier including the PVO microsphere, a composition for anti-oxidation, anti-inflammation, and cancer cell metastasis control, and a composition for preventing or treating ischemic diseases. The PVO microsphere according to the present invention is non-toxic and has excellent biocompatibility. The PVO microsphere sensitively reacts to low pH and peroxide which are physiological conditions exhibited in inflammatory tissues and cells to discharge vanillin so that excellent anti-oxidation and anti-inflammation effects are ensured. The PVO microsphere has a cancer cell metastasis control activity and an excellent therapeutic effect for ischemic diseases so as to be used in various medical fields.
Abstract translation: 本发明涉及聚（香草醛草酸盐）（PVO）共聚物，包含PVO共聚物的PVO微球，包含PVO微球的药物载体，用于抗氧化，抗炎和癌细胞转移控制的组合物，以及 用于预防或治疗缺血性疾病的组合物。 本发明的PVO微球无毒，生物相容性优异。 PVO微球敏感地反应低pH和过氧化物，这是炎性组织和细胞中出现的生理条件以排出香草醛，从而确保优异的抗氧化和抗炎作用。 PVO微球具有癌细胞转移控制活性，对缺血性疾病具有优异的治疗作用，可用于各种医疗领域。
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