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Patent Agency Ranking
公开(公告)号：KR1020110085818A
公开(公告)日：2011-07-27
申请号：KR1020100025453
申请日：2010-03-22
Applicant: 전북대학교산학협력단
IPC: C12N5/02 , C12N5/0735 , A61K31/375 , A61K38/43
Abstract: PURPOSE: A chromosomal aberration inhibitor of stem cells, which is treated with an antioxidant is provided to produce a large amount of stem cells and to prevent mutation of cells into tumor cells. CONSTITUTION: A chromosomal aberration inhibitor of stem cells contains an antioxidant as an active ingredient. The antioxidant is vitamin C or catalase. The cell is stem cells derived from embryo, adult, and fetus. The inhibitor suppresses tumorogenesis of the stem cells. A pharmaceutical composition contains the stem cells. The composition is administered by topical injection, oral administration, or parenteral administration.
Abstract translation: 目的：提供用抗氧化剂治疗的干细胞染色体畸变抑制剂，以产生大量的干细胞，并防止细胞突变成肿瘤细胞。 构成：干细胞的染色体畸变抑制剂含有抗氧化剂作为活性成分。 抗氧化剂是维生素C或过氧化氢酶。 细胞是源自胚胎，成年和胎儿的干细胞。 抑制剂抑制干细胞的肿瘤形成。 药物组合物含有干细胞。 组合物通过局部注射，口服给药或肠胃外给药来施用。
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公开(公告)号：KR1020110085739A
公开(公告)日：2011-07-27
申请号：KR1020100005685
申请日：2010-01-21
Applicant: 전북대학교산학협력단
IPC: C12N5/0735 , C12N5/02 , C12N1/38
Abstract: PURPOSE: A method for suppressing chromosomal aberration due to continuous sub-culture is provided to safely culture embryonic stem cells without mutation to cancer cell. CONSTITUTION: A method for suppressing chromosomal aberration comprises a step of suppressing SIRT1 enzyme activity of pluripotent stem cells. The pluripotnent stem cells are derived from embryo or adult.
Abstract translation: 目的：提供一种抑制由于连续亚培养引起的染色体畸变的方法，以安全地培养胚胎干细胞而不突变为癌细胞。 构成：抑制染色体畸变的方法包括抑制多能干细胞的SIRT1酶活性的步骤。 多能干细胞来源于胚胎或成人。
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公开(公告)号：KR200487804Y1
公开(公告)日：2018-11-05
申请号：KR2020170004078
申请日：2017-08-02
Applicant: 전북대학교산학협력단
CPC classification number: A47G19/03 , A47G19/2205 , B65D5/244
Abstract: 본고안은종이로제작되고, 도구없이누구나쉽게조립할수 있으며, 조립전에는접시로, 조립후에는컵으로사용할수 있는접시겸용종이컵에관한것으로, 각구성을편리하게조립할수 있고, 뜨거운내용물이담겨있어도불편함없이운반할수 있으며, 평지위에안정적으로세워지고, 컵또는접시중 원하는용도로변형하여사용할수 있다.
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公开(公告)号：KR1020120128451A
公开(公告)日：2012-11-27
申请号：KR1020110046404
申请日：2011-05-17
Applicant: 전북대학교산학협력단
IPC: C12N5/0735 , C12N5/074
Abstract: PURPOSE: A method for inhibiting chromosomal aberration or tumorigenesis of cells is provided to produce stem cells with normal chromosome and to effectively prevent chromosomal aberration. CONSTITUTION: A method for inhibiting chromosomal aberration or tumorigenesis of cells comprises a step of suppressing SIRT1(silent information regulator T1) by deleting or inactivating SIRT1 gene. The SIRT1 is suppressed using Ex-527, sirtinol, nicotinamide(NAM), or splitomicin. The cells are plutipotent stem cells derived from embryo or adult. [Reference numerals] (AA) 10 passage R1 embryonic stem cell line; (BB) 25 passage R1 embryonic stem cell line; (CC) 25 passage R1 embryonic stem cell line + adding 500 nM Ex527; (DD) Survival rate(%); (EE) Days after injection
Abstract translation: 目的：提供抑制细胞染色体畸变或肿瘤发生的方法，以产生具有正常染色体的干细胞并有效预防染色体畸变。 构成：抑制细胞的染色体畸变或肿瘤发生的方法包括通过删除或失活SIRT1基因来抑制SIRT1（沉默信息调节剂T1）的步骤。 使用Ex-527，sirtinol，烟酰胺（NAM）或裂解微管蛋白抑制SIRT1。 细胞是衍生自胚胎或成体的多能干细胞。 （参考数字）（AA）10通道R1胚胎干细胞系; （BB）25通道R1胚胎干细胞系; （CC）25通道R1胚胎干细胞系+加入500nM Ex527; （DD）生存率（％）; （EE）注射后几天
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公开(公告)号：KR101716771B1
公开(公告)日：2017-03-28
申请号：KR1020100005685
申请日：2010-01-21
Applicant: 전북대학교산학협력단
IPC: C12N5/0735 , C12N5/02 , C12N1/38
Abstract: 본발명은시험관내반복계대배양으로인한염색체이상을억제하는방법에관한것으로, 보다구체적으로는, SIRT1 효소활성억제에의해전분화능줄기세포의염색체이상을억제하면서세포를배양하는방법을제공한다.
Abstract translation: 本发明涉及用于抑制由体外重复传代培养引起的染色体异常的方法，更具体地涉及用于培养细胞同时抑制能够分化成SIRT1酶活性的干细胞的染色体异常的方法。
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