公开(公告)号：KR1020090025557A

公开(公告)日：2009-03-11

申请号：KR1020070090501

申请日：2007-09-06

Applicant: 전북대학교산학협력단

Inventor： 김학용 ,  아리알산토쉬

IPC: B05D7/00 ,  B05D5/12 ,  B05D3/02 ,  B32B18/00

CPC classification number: B32B18/00 ,  B05D1/38 ,  B05D3/0254 ,  B05D7/586 ,  C03C2214/20 ,  C03C2214/30 ,  C09D1/00

Abstract: A complex matrix made of a thin film of an inorganic oxide and a manufacturing method thereof are provided to offer superior adhesive force between the inorganic oxide of thin film and a silicon wafer by forming a single layer of the inorganic oxide of thin film or a multilayer of the thin film. A manufacturing method for a complex matrix made of a thin film of an inorganic oxide comprises the following steps of: performing a sintering process after performing a first electric radiation process of a sol for radiating on a surface of a silicon water; forming an inorganic oxide thin film on the water; and performing the sintering process after performing a second electric radiation process of a sol different with the first used sol on the inorganic oxide thin film formed on a surface of another silicon wafer repeatedly. The inorganic oxide contained in the inorganic oxide thin film is one selected from a particle or fiber of which diameter is 1,000nm or less.

Abstract translation: 提供一种由无机氧化物薄膜制成的复合基体及其制造方法，其通过形成单层薄膜无机氧化物或多层膜来提供薄膜无机氧化物与硅晶片之间的优异粘附力 的薄膜。 一种由无机氧化物薄膜制成的复合基质的制造方法，包括以下步骤：在对硅水表面进行辐射的溶胶进行第一次电辐射处理后进行烧结处理; 在水上形成无机氧化物薄膜; 并且在与第一使用溶胶不同的溶胶进行与在另一硅片的表面上形成的无机氧化物薄膜重复的第二次放电处理之后进行烧结处理。 无机氧化物薄膜中所含的无机氧化物选自直径为1000nm以下的粒子或纤维。

公开(公告)号：KR1020070010469A

公开(公告)日：2007-01-24

申请号：KR1020050065065

申请日：2005-07-19

Applicant: 전북대학교산학협력단

Inventor： 김학용 ,  아리알산토쉬 ,  케이.시.레만트바하두르 ,  김치헌

IPC: C01B31/02 ,  A61K31/722 ,  B82B3/00 ,  B82Y40/00

CPC classification number: C01B32/174 ,  A61K31/722 ,  B82B3/0038 ,  B82B3/0076 ,  B82Y40/00

Abstract: Carbon nano tube-chitosan composite formed by covalent bonding is provided to noticeably improve bio-compatibility and solvent dispersion capability, thereby being advantageously applied to gene delivery system, by endowing acidic property to carbon nano tube through amide bond of amine compound and covalently bonding the nano tube to chitosan to produce the composite. The process of forming the composite includes the steps of: (i) incorporating carboxylic group to carbon nano-tube by mixing nitric acid and carbon nano-tube then carrying out reflux of the mixture; (ii) substituting the incorporated carboxylic group with -COCl group by filtering the obtained carbon nano tube, washing the tube with distilled water to have pH7, drying the treated tube, adding SOCl2 to the tube and refluxing the treated tube; (iii) preparing carbon nano tube-chitosan composite by filtering the nano tube with incorporation of -COCl group, washing the tube with anhydrous CH2Cl2, drying the treated tube, adding acetic acid containing dissolved chitosan to the tube and refuxing the treated mixture; and (iv) removing unreacted chitosan by washing the composite with acetic acid, filtering and washing the composite with distilled water to have pH7.

Abstract translation: 提供通过共价键形成的碳纳米管 - 壳聚糖复合物，以显着提高生物相容性和溶剂分散能力，从而有利地应用于基因递送系统，通过将胺性化合物的酰胺键赋予碳纳米管，并共价键合 纳米管对壳聚糖产生复合材料。 形成复合材料的方法包括以下步骤：（i）通过混合硝酸和碳纳米管将羧基引入碳纳米管，然后进行混合物的回流; （ii）通过过滤得到的碳纳米管，用-COCl基代替引入的羧基，用蒸馏水洗涤pH至pH7，干燥经处理的管，向管中加入SOCl2并回流处理的管; （iii）通过掺入-COCl基团过滤纳米管制备碳纳米管 - 壳聚糖复合物，用无水CH 2 Cl 2洗涤管，干燥经处理的管，向管中加入含有溶解的壳聚糖的乙酸，并将处理的混合物重新混合; 和（iv）通过用乙酸洗涤复合物除去未反应的壳聚糖，用蒸馏水过滤和洗涤复合物以具有pH7。

公开(公告)号：KR100739346B1

公开(公告)日：2007-07-16

申请号：KR1020060039354

申请日：2006-05-02

Applicant: 전북대학교산학협력단

Inventor： 김학용 ,  아리알산토쉬 ,  케이.시.레만트바하두르

IPC: D01F9/127 ,  D01D5/00 ,  B82Y30/00 ,  D04H1/4242 ,  D01F9/12

公开(公告)号：KR100702873B1

公开(公告)日：2007-04-03

申请号：KR1020050065065

申请日：2005-07-19

Applicant: 전북대학교산학협력단

Inventor： 김학용 ,  아리알산토쉬 ,  케이.시.레만트바하두르 ,  김치헌

IPC: C01B31/02 ,  A61K31/722 ,  B82B3/00 ,  B82Y40/00

Abstract: 본 발명은 카본나노튜브-키토산 복합체 및 그의 제조 방법에 관한 것으로서, 아래의 공정들을 거쳐 유기용매에 대해 분산성이 뛰어난 카본나노튜브-키토산 복합체를 제조한다.
-- 아 래 --
(ⅰ) 질산과 카본나노튜브를 혼합한 다음, 이들을 환류(Reflex)시켜 카본나노튜브에 카르복실기를 도입시키는 공정,
(ⅱ) 카르복실기가 도입된 카본나노튜브를 여과, 증류수로 pH가 7일 될 때까지 세척 및 건조한 다음, 여기에 SOCl
2 를 혼합한 후 이들을 환류(Reflex)시켜 카본나노튜브에 도입된 카르복실기를 -COCl기로 치환하는 공정,
(ⅲ) -COCl기가 도입된 카본나노튜브를 여과, 무수의 CH
2 Cl
2 로 세척 및 건조한 다음, 여기에 키토산이 용해된 초산을 혼합한 후 이들을 환류(Reflex)시켜 카본나노튜브-키토산 복합체를 제조하는 공정 및
(ⅳ) 제조된 카본나노튜브-키토산 복합체를 초산으로 세척하여 미반응 키토산을 제거한 다음, 여과 후 pH가 7이 될 때까지 증류수로 세척하는 공정.
복합체, 키토산, 카본나노튜브, 유기용매 분산성, 유전자, 약물, 전달체

公开(公告)号：KR100795345B1

公开(公告)日：2008-01-17

申请号：KR1020060089416

申请日：2006-09-15

Applicant: 전북대학교산학협력단

Inventor： 김학용 ,  케이.시.레만트바하두르 ,  아리알산토쉬

IPC: C01B25/32 ,  B82B3/00 ,  A61L24/02 ,  B82Y40/00

CPC classification number: C01B25/32 ,  C01P2004/64 ,  C01P2006/12 ,  C01P2006/90

Abstract: A method for preparing a hydroxyl-apatite nano-complex is provided to generate nano-scaled crystals within the hydroxyl-apatite nano-complex, thereby increasing the surface area of the nano-complex and decrease the reduction of strength of the nano-complex. A gold nanoparticle solution stabilized with N-acylated chitosan is prepared by mixing and stirring HAuCL4 solution and an N-acylated chitosan solution for 1-2 hours and then adding NaBH4 into the mixed substance. A product in which hydroxyapatite is crystallized on gold nanoparticles is produced by aging the gold nanoparticle solution for 1-2 hours while adding a CaCl2 solution into the gold nanoparticle solution, and then aging the aged substance for 1-3 hours while adding NaHPQ into the aged substance. The product is refined and centrifuged.

Abstract translation: 提供一种制备羟基磷灰石纳米复合物的方法，以在羟基磷灰石纳米复合物内产生纳米级晶体，从而增加纳米复合物的表面积，并降低纳米复合物的强度。 通过将HAuCL4溶液和N-酰化壳聚糖溶液混合搅拌1-2小时，然后将NaBH 4加入到混合物中制备用N-酰化壳聚糖稳定的金纳米颗粒溶液。 羟基磷灰石在金纳米颗粒上结晶的产物是通过将金纳米颗粒溶液老化1-2小时，同时向金纳米颗粒溶液中加入CaCl 2溶液，然后将老化物质老化1-3小时，同时将NaHPQ加入到 老化物质。 将产品精制和离心。