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公开(公告)号：KR1020120139311A
公开(公告)日：2012-12-27
申请号：KR1020110059046
申请日：2011-06-17
Applicant: 전북대학교산학협력단 , 전북대학교병원
CPC classification number: A61K38/193 , C07K14/535 , Y10S530/837
Abstract: PURPOSE: A lymphatic vascularization composition containing granulocyte-colony stimulating-factors is provided to induce capillarization, cell proliferation, and lymphatic sprout of human lymphatic vascular endothelial cells. CONSTITUTION: A lymphatic vascularization composition contains granulocyte-colony stimulating-factors as an active ingredient. The granulocyte-colony stimulating-factors include granulocyte macrophage colony stimulating factors(GM-CSF) and macrophage colony stimulating factors(MCSF). A composition for preventing or treating lymphedema contains the granulocyte-colony stimulating-factors as an active ingredient. A composition for preventing or treating lymphatic vessel loss or lymphopenia contains the granulocyte-colony stimulating-factors. An agent for enhancing ERK1/2 phosphorylation and Akt phosphorylation contains the granulocyte-colony stimulating-factors as an active ingredient.
Abstract translation: 目的：提供含有粒细胞集落刺激因子的淋巴管血管化组合物，以诱导人淋巴管血管内皮细胞的毛细血管化，细胞增殖和淋巴发芽。 构成：淋巴管血管化组合物含有粒细胞集落刺激因子作为活性成分。 粒细胞集落刺激因子包括粒细胞巨噬细胞集落刺激因子（GM-CSF）和巨噬细胞集落刺激因子（MCSF）。 用于预防或治疗淋巴水肿的组合物含有作为活性成分的粒细胞集落刺激因子。 用于预防或治疗淋巴管损失或淋巴细胞减少的组合物含有粒细胞集落刺激因子。 增强ERK1 / 2磷酸化和Akt磷酸化的药物含有粒细胞集落刺激因子作为活性成分。
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Patent Agency Ranking
公开(公告)号：KR1020150113273A
公开(公告)日：2015-10-08
申请号：KR1020140036038
申请日：2014-03-27
Applicant: 전북대학교산학협력단 , 전북대학교병원
IPC: A61K31/728 , A61P35/00 , A61P29/00
CPC classification number: A61K31/728 , Y10S514/886
Abstract: 본발명의히알루론산을포함하는림프혈관생성약학적조성물에관한것으로서, 보다상세하게는림프혈관내피세포의세포유주(migration), 모세관형성, 세포증식및 림프관발아를유도하여림프혈관을생성하는데효과적인림프혈관생성약학적조성물에관한것이다.
Abstract translation: 本发明涉及一种用于生产含有透明质酸的淋巴管的药物组合物，更具体地，涉及用于产生淋巴管的药物组合物，所述药物组合物可以通过诱导淋巴管中的内皮细胞的细胞迁移，毛细血管形成，细胞，能够有效地产生淋巴管 增殖和淋巴管发育。
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公开(公告)号：KR101336386B1
公开(公告)日：2013-12-04
申请号：KR1020110059046
申请日：2011-06-17
Applicant: 전북대학교산학협력단 , 전북대학교병원
Abstract: 본 발명은 과립구집락자극인자를 유효성분으로 포함하는 림프관 생성 유도제에 관한 것이다. 본 발명에서는 과립구집락자극인자가 사람 림프관내피 세포에서 세포 유주, 모세관 형성, 세포 증식, 림프관 발아를 유도하는 것을 확인하였고, 이러한 기작을 통하여 림프관을 생성한다. 또한 과립구집락자극인자는 사람 림프관내피 세포에서 맵 키나아제(MAP kinase)와 Akt 신호전달계를 통하여 림프관 생성을 유도할 수 있다.
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公开(公告)号：KR1020120040041A
公开(公告)日：2012-04-26
申请号：KR1020100101549
申请日：2010-10-18
Applicant: 전북대학교산학협력단
CPC classification number: A61K38/1816 , C07K14/505
Abstract: PURPOSE: A lymphoduct generation inducer containing erythropoietin is provided to induce lymphduct through Akt/ERK pathway in human lymph vascular epithelial cells. CONSTITUTION: A lymphoduct generation inducer contains erythropoietin as an active ingredient. A composition for preventing or treating lymphedema contains erythropoietin as an active ingredient. A composition for preventing or treating lymphoduct loss or lymphopenia contains the erythropoietin as an active ingredient.
Abstract translation: 目的：提供含有促红细胞生成素的淋巴产生诱导物，通过人淋巴管上皮细胞中的Akt / ERK途径诱导淋巴细胞生成。 构成：产生淋巴产生的诱导物含有促红细胞生成素作为活性成分。 用于预防或治疗淋巴水肿的组合物含有促红细胞生成素作为活性成分。 用于预防或治疗淋巴细胞减少或淋巴细胞减少的组合物含有红细胞生成素作为活性成分。
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公开(公告)号：KR101622786B1
公开(公告)日：2016-05-20
申请号：KR1020140036038
申请日：2014-03-27
Applicant: 전북대학교산학협력단 , 전북대학교병원
IPC: A61K31/728 , A61P35/00 , A61P29/00
Abstract: 본발명의히알루론산을포함하는림프혈관생성약학적조성물에관한것으로서, 보다상세하게는림프혈관내피세포의세포유주(migration), 모세관형성, 세포증식및 림프관발아를유도하여림프혈관을생성하는데효과적인림프혈관생성약학적조성물에관한것이다.
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