公开(公告)号：KR1020100092570A

公开(公告)日：2010-08-23

申请号：KR1020090011741

申请日：2009-02-13

Applicant: 전북대학교산학협력단 ,  한국식품연구원

Inventor： 박성광 ,  권대영 ,  김원 ,  성미정 ,  김덕훈

IPC: A61K31/352 ,  A61P13/12

Abstract: PURPOSE: A composition containing genistein for preventing and treating inflammatory renal diseases is provided to suppress inflammatory renal diseases including acute renal injury. CONSTITUTION: A composition for preventing and treating inflammatory renal disease contains genistein. The disease is a disease cause by anticancer drug administration. The anticancer drug is cisplatin(cis-Diamminedichloroplatinum). Genistein reduces ICAM-1 and MCP-1 expression and suppresses NF-kappaB activation and ROS generation.

Abstract translation: 目的：提供含有用于预防和治疗炎症性肾病的染料木素的组合物，以抑制炎症性肾病，包括急性肾损伤。 构成：用于预防和治疗炎症性肾病的组合物含有染料木素。 该疾病是抗癌药物给药引起的疾病。 抗癌药物是顺铂（顺式二氨基氯铂）。 染料木黄酮降低ICAM-1和MCP-1表达，抑制NF-κB活化和ROS产生。

公开(公告)号：KR1020130121527A

公开(公告)日：2013-11-06

申请号：KR1020120044806

申请日：2012-04-27

Applicant: 전북대학교산학협력단

Inventor： 김원 ,  박성광 ,  강경표 ,  김덕훈 ,  정유진

IPC: A61K38/17 ,  A61P3/04 ,  A61P3/00

CPC classification number: A61K38/17 ,  A23L33/17 ,  A23V2200/332 ,  C07K14/435 ,  Y10S514/909

Abstract: The present invention relates to a composition containing cartilage oligomeric matrix protein-angiopoietin-1 as an active ingredient for reducing the size of cells. As a result of testing using an experimental animal, the composition is identified to reduce the size of adipocytes and the concentration of tumor necrosis factor-alpha released from adipose tissues and resistin in blood, increase the density of blood vessels, and improve insulin resistance.

Abstract translation: 本发明涉及含有软骨低聚基质蛋白 - 血管生成素-1作为减少细胞大小的活性成分的组合物。 作为使用实验动物进行测试的结果，鉴定组合物以减少脂肪细胞的大小和从脂肪组织释放的肿瘤坏死因子-α的浓度和血液中的抵抗力，增加血管密度并改善胰岛素抵抗。