公开(公告)号：KR1020110085151A

公开(公告)日：2011-07-27

申请号：KR1020100004768

申请日：2010-01-19

Applicant: 주식회사한국신약

Inventor： 유익동 ,  허광화 ,  유재국 ,  김진표

IPC: A61K31/7028 ,  A61K8/97 ,  A61Q19/00

CPC classification number: A61K31/7028 ,  A23L33/105 ,  A61K8/60 ,  A61K8/97 ,  A61K36/185 ,  A61K2236/33 ,  A61Q19/08

Abstract: PURPOSE: A novel megastigmane derivative or pharmaceutically acceptable salt thereof is provided to prevent or treat wrinkling. CONSTITUTION: A megastigmane derivative or pharmaceutically acceptable salt thereof is denoted by chemical formula 1 or 2. A method for preparing the megastigmane derivative comprises: a step of adding water, organic solvent, or mixture solvent thereof to Ilex paraguariensis to prepare Ilex paraguariensis extract; a step of fractioning the Ilex paraguariensis extract with n-hexane and ethyl acetate to prepare an Ilex paraguariensis fraction; and a step of performing column chromatography.

Abstract translation: 目的：提供一种新型的巨型衍生物衍生物或其药学上可接受的盐以防止或治疗皱纹。 构成：大分子衍生物或其药学上可接受的盐由化学式1或化学式2表示。一种制备该超巨族衍生物衍生物的方法包括：将水，有机溶剂或其混合溶剂加入到白僵菌中以制备白僵菌提取物的步骤; 用正己烷和乙酸乙酯分离枸杞提取物以制备枸杞子的步骤; 和进行柱色谱的步骤。

公开(公告)号：KR101077229B1

公开(公告)日：2011-10-27

申请号：KR1020100004768

申请日：2010-01-19

Applicant: 주식회사한국신약

Inventor： 유익동 ,  허광화 ,  유재국 ,  김진표

IPC: A61K31/7028 ,  A61K8/97 ,  A61Q19/00

Abstract: 본발명은하기화학식 1 또는화학식 2로표시되는메가스티그만유도체또는이의약학적으로허용가능한염, 이의제조방법및 이를유효성분으로함유하는주름개선용조성물에관한것으로, 본발명에따른메가스티그만유도체화합물은사람중성구엘라스타제활성을효과적으로저해하여우수한피부주름개선효과를나타내므로이들을유효성분으로함유하는조성물은주름개선을위한의약품, 화장품또는식품에유용하게사용될수 있다. [화학식 1][화학식 2]

公开(公告)号：KR1020110043195A

公开(公告)日：2011-04-27

申请号：KR1020090100207

申请日：2009-10-21

Applicant: 주식회사한국신약

Inventor： 유익동 ,  허광화 ,  유재국 ,  한상욱

IPC: A61K31/192 ,  A61P17/18 ,  A61K31/216 ,  A61K8/36

Abstract: PURPOSE: A composition containing caffeoyl quinic acid derivatives and pharmaceutically acceptable salt thereof is provided to effectively suppress elastase activity of human neutrophil and to ensure anti-wrinkling. CONSTITUTION: A composition contains caffeoyl quinic acid derivatives and pharmaceutically acceptable salt thereof as an active ingredient. The composition is derived from one selected from the group consisting of (1S,3R,4R,5R)-3,4-bis((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)-1,5 dihydroxycyclohexane carboxylic acid, (1S,3R,4R,5R)-methyl-3,4-bis((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)-1,5-dihydroxycyclohexanecarboxylate, (1R,3R,4S,5R)-methyl-4,5-bis((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)-1,5-dihydroxycyclohexanecarboxylate, (1S,3R,4S,5R)-3,5-bis((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)-1,4-dihydroxycyclohexanecarboxylic acid, and (1S,3R,4S,5R)-methyl-3,5-bis((E)-3-(3,4-dihydroxyphenyl)acryloyloxy)-1,4-dihydroxycyclohexanecarboxylate.

Abstract translation: 目的：提供含有咖啡酰奎尼酸衍生物及其药学上可接受的盐的组合物，以有效抑制人嗜中性粒细胞的弹性蛋白酶活性并确保抗皱纹。 构成：组合物含有咖啡酰奎尼酸衍生物及其药学上可接受的盐作为活性成分。 该组合物衍生自选自（1S，3R，4R，5R）-3,4-双（（E）-3-（3,4-二羟基苯基）丙烯酰氧基）-1,5-二羟基环己烷羧酸 ，（1S，3R，4R，5R） - 甲基-3,4-二（（E）-3-（3,4-二羟基苯基）丙烯酰氧基）-1,5-二羟基环己烷羧酸酯，（1R，3R，4S，5R） （（E）-3-（3,4-二羟基苯基）丙烯酰氧基）-1,5-二羟基环己烷羧酸酯，（1S，3R，4S，5R）-3,5-双（（E） -3-（3,4-二羟基苯基）丙烯酰氧基）-1,4-二羟基环己烷羧酸和（1S，3R，4S，5R） - 甲基-3,5-双（（E） 二羟基苯基）丙烯酰氧基）-1,4- dihydroxycyclohexanecarboxylate。

公开(公告)号：KR1020110043194A

公开(公告)日：2011-04-27

申请号：KR1020090100206

申请日：2009-10-21

Applicant: 주식회사한국신약

Inventor： 유익동 ,  허광화 ,  유재국 ,  한상욱

IPC: A61K36/185 ,  A61P17/18 ,  A61K8/97 ,  A23L1/30

Abstract: PURPOSE: A composition containing Ilex paraguayensis extract or fraction thereof is provided to effectively suppress elastase activity and to ensure anti-wrinkling effect. CONSTITUTION: A composition contains Ilex paraguayensis extract or fraction thereof as an active ingredient. The extract is isolated using water, organic solvent, or mixture thereof. A method for preparing a pharmaceutical composition containing Ilex paraguayensis extract and fraction for anti-wrinkling comprises: a step of extracting Ilex paraguayensis with water, organic solvent, or mixture solvent thereof; and a step of fractioning the extract with n-hexane and ethyl acetate.

Abstract translation: 目的：提供含有白藜芦醇提取物或其馏分的组合物以有效抑制弹性蛋白酶活性并确保抗起皱效果。 构成：组合物含有作为活性成分的白藜芦醇提取物或其分数。 使用水，有机溶剂或其混合物分离提取物。 一种制备含有白僵菌提取物和用于抗皱的部分的药物组合物的方法包括：用水，有机溶剂或其混合溶剂萃取白藜芦醇的步骤; 和用正己烷和乙酸乙酯分级提取物的步骤。