公开(公告)号：KR1020110039157A

公开(公告)日：2011-04-15

申请号：KR1020090096481

申请日：2009-10-09

Applicant: 중앙대학교 산학협력단 ,  서울대학교산학협력단

Inventor： 안상두 ,  장석규 ,  주현혜 ,  최명길

IPC: C07D493/10 ,  C07D493/02

Abstract: PURPOSE: A method for preparing pyrenyl-butane-amide fluorescein for analyzing water content is provided to be used as a sensor for determining water content. CONSTITUTION: A pyrenyl-butane-amide fluorescein derivative for analyzing water content in an organic solvent has a structure of chemical formula 1. The pyrenyl-butane-amide fluorescein derivative is synthesized using pyrene and fluorescein. The water content is measured by fluorescence spectrofluorimetry using less than 2% of water.

Abstract translation: 目的：制备用于分析含水量的芘甲酰 - 丁酰胺荧光素的方法，用作测定含水量的传感器。 构成：用于分析有机溶剂中水分含量的芘甲基 - 丁烷 - 酰胺荧光素衍生物具有化学式1的结构。使用芘和荧光素合成芘基 - 丁烷 - 酰胺荧光素衍生物。 通过使用少于2％的水的荧光分光荧光测定法测量水含量。

公开(公告)号：KR1020100096868A

公开(公告)日：2010-09-02

申请号：KR1020090015942

申请日：2009-02-25

Applicant: 중앙대학교 산학협력단 ,  서울대학교산학협력단

Inventor： 한민수 ,  장석규 ,  안지연 ,  장현혜 ,  이수정 ,  김미희 ,  이나희 ,  류대훈 ,  최길돈 ,  정대영

IPC: G01N33/573 ,  G01N33/533

Abstract: PURPOSE: A composition for selectively NADH and a fluorescence chemical sensor are provided to ensure high selectivity to NADA detection. CONSTITUTION: A composition for detecting NADH(nicotinamide adenine dinucleotide reduced form) contains a compound of chemical formula 1. The composition additionally contains buffer solution. The buffer solution is a sodium phosphate buffer solution. The concentration of the sodium phosphate buffer solution is 0.5mM-5M. The buffer solution additionally contains salt. The salt is NaCl or NaNO_3. A method for detecting NADH comprises: a step of contacting a sample with the composition; and a step of probing fluorescence change by reaction.

Abstract translation: 目的：提供选择性NADH和荧光化学传感器的组合物，以确保对NADA检测的高选择性。 构成：用于检测NADH（烟酰胺腺嘌呤二核苷酸还原形式）的组合物含有化学式1的化合物。该组合物还含有缓冲溶液。 缓冲液是磷酸钠缓冲溶液。 磷酸钠缓冲溶液的浓度为0.5mM-5M。 缓冲液还含有盐。 盐是NaCl或NaNO_3。 检测NADH的方法包括：使样品与组合物接触的步骤; 以及通过反应探测荧光变化的步骤。

公开(公告)号：KR101083031B1

公开(公告)日：2011-11-16

申请号：KR1020090015942

申请日：2009-02-25

Applicant: 중앙대학교 산학협력단 ,  서울대학교산학협력단

Inventor： 한민수 ,  장석규 ,  안지연 ,  장현혜 ,  이수정 ,  김미희 ,  이나희 ,  류대훈 ,  최길돈 ,  정대영

IPC: G01N33/573 ,  G01N33/533

Abstract: 본 발명은 NADH를 선택적으로 검출할 수 있는 형광 화학센서에 관한 것이다. 화학식 1의 화합물은 NADH 검출에 있어 다른 음이온에 대비하여 높은 선택성을 가진다. 화학식 1의 화합물과 NADH와의 결합으로 인한 형광 변화는 육안으로도 관찰 가능하고, 반응 직후 신속한 탐지가 가능하며, 다양한 pH 범위 내에서 검출이 가능하기 때문에, 화학식 1의 화합물을 포함하는 조성물을 이용하여 생체 시료 및 일반 시료에서 NADH를 효율적으로 검출할 수 있다. 또한 상기 조성물을 이용하여 NADH 또는 NAD를 조효소로 사용하는 다양한 효소의 활성을 측정할 수 있고, 상기 효소의 활성화제 또는 억제제를 고속 스크리닝할 수 있다.
NADH, 형광 화학센서

公开(公告)号：KR1020110039158A

公开(公告)日：2011-04-15

申请号：KR1020090096482

申请日：2009-10-09

Applicant: 중앙대학교 산학협력단 ,  서울대학교산학협력단

Inventor： 안상두 ,  장석규 ,  주현혜 ,  최명길

IPC: C07D493/10 ,  C07D493/02

Abstract: PURPOSE: A bis(pyrenyl-methyl-amino)fluorescein derivative for analyzing water content is provided to optically and simply measure water content in an organic solvent. CONSTITUTION: A bis(pyrenyl-methyl-amino)fluorescein derivative for analyzing water content in an organic solvent has a structure of chemical formula 1. The bis(pyrenyl-methyl-amino)fluorescein derivative of chemical formula 1 is synthesized using pyrene and fluorescein. The water content in the organic solvent is measured using the fluorescein derivative of chemical formula 1 as a probe. A sensor for determining water content has the fluorescein derivative of chemical formula 1 as a probe.

Abstract translation: 目的：提供用于分析含水量的双（芘基 - 甲基 - 氨基）荧光素衍生物，以光学和简单地测量有机溶剂中的含水量。 构成：用于分析有机溶剂中水含量的双（芘基 - 甲基 - 氨基）荧光素衍生物具有化学式1的结构。化学式1的双（芘基 - 甲基 - 氨基）荧光素衍生物使用芘和荧光素 。 使用化学式1的荧光素衍生物作为探针测定有机溶剂中的水分含量。 用于测定含水量的传感器具有化学式1的荧光素衍生物作为探针。

公开(公告)号：KR1020170080865A

公开(公告)日：2017-07-11

申请号：KR1020150190267

申请日：2015-12-30

Applicant: 중앙대학교 산학협력단

Inventor： 장석규 ,  이슬기

IPC: G01N31/22 ,  G01N21/77 ,  C07D251/32 ,  C07D251/28

Abstract: 클로라민류인트리클로로시아누익산검출용조성물및 상기트리클로로시아누익산검출용조성물을이용한트리클로로시아누익산검출방법에관한것이다.

Abstract translation: 以及使用三氯胂酸类检测用组合物检测三氯蔗糖酸的方法。

公开(公告)号：KR1020130077402A

公开(公告)日：2013-07-09

申请号：KR1020110146094

申请日：2011-12-29

Applicant: 중앙대학교 산학협력단

Inventor： 장석규 ,  최명길 ,  황지영 ,  문정옥 ,  어수영

IPC: C07D311/06 ,  C07D265/38 ,  G01N31/22 ,  G01N21/78

Abstract: PURPOSE: A chemosensor having selectivity for hydrazine is provided to be used as a selective turn on type fluorescence sensor as the fluorescence intensity is remarkably increased by deprotection reaction in which the lebulinyl group is cut by hydrazine, and to detect the hydrazine with the naked eye using color reaction. CONSTITUTION: A compound represented by the chemical formula 1 is provided. The compound of the chemical formula 1 is the compound represented by the below chemical formula 1a. A sensor for detecting hydrazine comprises a compound represented by the chemical formula 2. A composition for detecting hydrazine comprises: the compound represented by the below chemical formula 2; and a mixed solution containing acetate buffer solution and DMSO aqueous solution. A method for detecting hydrazine is to use the above sensor. Hydrazine is detected by reacting the sensor with the sample containing hydrazine under the solution mixing the acetate buffer solution having a pH of 3-6 and 1-99% of DMSO aqueous solution.

Abstract translation: 目的：提供对肼具有选择性的化学传感器，作为选择性转接型荧光传感器，其荧光强度通过脱乙酰基被肼切割的脱保护反应显着增加，并用肉眼检测肼 使用颜色反应。 构成：提供由化学式1表示的化合物。 化学式1的化合物是下述化学式1a表示的化合物。 用于检测肼的传感器包括由化学式2表示的化合物。用于检测肼的组合物包括：由下列化学式2表示的化合物; 和含有乙酸盐缓冲溶液和DMSO水溶液的混合溶液。 检测肼的方法是使用上述传感器。 通过使该传感器与含有肼的样品在混合pH为3-6的乙酸盐缓冲溶液和1〜99％DMSO水溶液的溶液下进行反应来检测肼。

公开(公告)号：KR101261470B1

公开(公告)日：2013-05-10

申请号：KR1020100120831

申请日：2010-11-30

Applicant: 중앙대학교 산학협력단

Inventor： 장석규 ,  최명길 ,  어수영 ,  황지영

IPC: C07D265/38 ,  G01N21/78

CPC classification number: C07D265/38 ,  Y10T436/18

Abstract: 본발명은아황산이온선택성을갖는레소루핀계화합물을포함하는센서및 이를이용한아황산이온검출방법에관한것으로, 보다상세하게는레소루핀계화합물이아황산이온에의해레불리닐기가절단되는탈보호반응에의해형광세기가현저히증가하여턴-온타입의선택적형광센서로사용할수 있고, 또한, 발색변화를나타내므로육안으로아황산이온을검출할수 있다.

公开(公告)号：KR1020170080854A

公开(公告)日：2017-07-11

申请号：KR1020150190196

申请日：2015-12-30

Applicant: 중앙대학교 산학협력단

Inventor： 장석규 ,  김홍영 ,  이효진

IPC: G01N31/22 ,  G01N21/77 ,  C07D231/16 ,  C07D231/18

Abstract: 페놀및 아미노안티피린계화합물의혼합물을이용한구리이온검출방법에관한것이다.

Abstract translation: 苯酚和氨基安替比林为基础的化合物。

公开(公告)号：KR101416750B1

公开(公告)日：2014-07-14

申请号：KR1020130011690

申请日：2013-02-01

Applicant: 중앙대학교 산학협력단

Inventor： 장석규 ,  손태호 ,  문정옥 ,  최명길 ,  조윤하

IPC: G01N31/22 ,  G01N21/78 ,  C07D491/10

Abstract: The present invention provides a probe for detecting hypervalent iodine compounds including rhodamine-hydroxamic acid compounds represented by the chemical formula 1 below. In formula 1, R1 is hydrogen, halogen, or C1-C5 linear or branched alkyl, n is an integer between 1 and 4, and R2 to R5 are independently H or C1-C5 linear or branched alkyl.

Abstract translation: 本发明提供了一种用于检测包含由下述化学式1表示的若丹明 - 异羟肟酸化合物的多价碘化合物的探针。 在式1中，R 1是氢，卤素或C 1 -C 5直链或支链烷基，n是1和4之间的整数，R2至R5独立地是H或C1-C5直链或支链烷基。

公开(公告)号：KR1020120050702A

公开(公告)日：2012-05-21

申请号：KR1020100112093

申请日：2010-11-11

Applicant: 중앙대학교 산학협력단

Inventor： 장석규 ,  차선영 ,  황지영 ,  최명길

IPC: C07D311/06 ,  G01N21/77

Abstract: PURPOSE: A sensor containing thiocoumarin-based compounds with meta-chloroperbenzoic acid selectivity is provided to enhance fluorescence intensity and to detect meta-chloroperbenzoic acid with naked eyes. CONSTITUTION: A thiocoumarin-based compounds with meta-chloroperbenzoic acid is denoted by chemical formula 1. A composition for detecting meta-chloroperbenzoic acid contains the compound. A method for detecting meta-chloroperbenzoic acid comprises a step of reacting a sample with the compound of chemical formula 1 at pH 4.0-9.0 and a step of measuring meta-chloroperbenzoic acid signalization by absorbance ratio(A406/A324).

Abstract translation: 目的：提供含有间氯过苯甲酸选择性的基于硫代香豆素的化合物的传感器，以增强荧光强度并用肉眼检测间氯过苯甲酸。 构成：用间氯过苯甲酸的硫代香豆素类化合物由化学式1表示。用于检测间氯过苯甲酸的组合物含有该化合物。 检测间氯过苯甲酸的方法包括使样品与pH 4.0-9.0的化学式1的化合物反应的步骤和通过吸光度比（A406 / A324）测量间氯过苯甲酸信号的步骤。