Abstract:
PURPOSE: A pharmaceutical composition for preventing and treating cancer, which contains an expression vector containing p19ras gene or p19ras protein is provided to suppress abnormal proliferation. CONSTITUTION: A pharmaceutical composition for preventing or treating cancer contains an expression vector of p19ras gene or p19ras protein. The p19ras gene is denoted by sequence of the sequence number 1. The cancer is a cancer in which NSE is overexpressed.
Abstract:
본 발명은 신경퇴행성 질환에 관여하는 CP2 전사인자에 관한 것이다. 본 발명은 다운 스트림(downstream)에 위치하는 발병 유전자를 전사 기작 측면에서 조절한다는 특이성이 있으며, 이는 종래의 APP 유전자나 이에 관련된 효소들의 억제방법에서 야기되는 심각한 신경발생 장애와 같은 부작용 없이 치료가 가능하다. 또한, 본 발명은 신경 퇴행성 질환(특히, 알츠하이머병)을 치료하는데 있어서 CP2 전사인자의 조절을 통한 신약 개발 및 치료방법에 기초적인 자료를 제공한다. CP2, 알츠하이머, 진단, 키트, 스크리닝
Abstract:
PURPOSE: A neurodegenerative disease-related CP2 transcription factor is provided to treat neurodegenerative diseases without side effects. CONSTITUTION: A kit for diagnosing neurodegenerative diseases comprises a nucleotide sequence of CP2 of sequence number 1, complementary sequence of the nucleotide, nucleotide fragment, or an antibody or aptamer which specifically binds to CP2 protein of sequence number 2. The kit is a microarray. A method for screening a material which prevents or treats neurodegenerative diseases comprises: a step of contacting a sample to cells containing CP2 gene or protein; and a step of measuring expression level of CP2 gene, CP2 protein level, or CP2 protein activity.