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    결핵균의 Ｒｖ０５７７ 단백질을 이용한 수지상 세포의 성숙방법
    1.
    发明公开
    결핵균의 Ｒｖ０５７７ 단백질을 이용한 수지상 세포의 성숙방법 有权
    使用M.TUBERCULOSIS RV0577的感染细胞的成熟方法

    公开(公告)号：KR1020130012455A

    公开(公告)日：2013-02-04

    申请号：KR1020110073680

    申请日：2011-07-25

    Applicant: 충남대학교산학협력단

    Inventor： 신성재 ,  김화중 ,  변의홍 ,  김우식 ,  김종석

    IPC: C12N5/0784 ,  C12N1/38 ,  C07K14/195

    Abstract: PURPOSE: A composition which contains RV0577 and induces dendritic cell maturation is provided to effectively activate immune response. CONSTITUTION: A composition which induces dendritic cell matutaton contains 1-10 ug/ml of RV0577 protein as an active ingredient. The protein is derived from M-tuberculosis. RV0577 protein enhances the expression of CD(Cluster of Differentiation)80, CD86, MHC(Major Histocompatibility Complex)-class I, II in a dendritic cell. A method for inducing maturation of the immature dendritic cells comprises: a step of sorting the immature dendritic cells; and a step of treating 1-10 ug/ml of RV0577 protein to the sorted immature dendritic cells.

    Abstract translation: 目的：提供含有RV0577并诱导树突状细胞成熟的组合物以有效激活免疫应答。 构成：诱导树突状细胞成熟的组合物含有1-10ug / ml的RV0577蛋白作为活性成分。 该蛋白质来源于结核分枝杆菌。 树突状细胞中RV0577蛋白增强CD（分化簇）80，CD86，MHC（主要组织相容性复合物） - I，II型的表达。 诱导未成熟树突状细胞成熟的方法包括：分选未成熟树突状细胞的步骤; 以及将1-10ug / ml的RV0577蛋白质处理至分选的未成熟树突状细胞的步骤。

    결핵균의 Ｒｖ２２９９ｃ 단백질을 이용한 수지상 세포의 성숙방법
    2.
    发明公开
    결핵균의 Ｒｖ２２９９ｃ 단백질을 이용한 수지상 세포의 성숙방법 有权
    使用MYCOBACTERIUM TUBCCOSOS RV2299C的感染细胞的成熟方法

    公开(公告)号：KR1020130039061A

    公开(公告)日：2013-04-19

    申请号：KR1020110103498

    申请日：2011-10-11

    Applicant: 충남대학교산학협력단

    Inventor： 신성재 ,  최한규 ,  변의홍 ,  김우식 ,  김종석 ,  김화중

    IPC: C12N5/0784 ,  C12N1/38 ,  C07K14/195

    Abstract: PURPOSE: A method for maturing dendritic cells is provided to promote differentiation of immature dendritic cells using Mycobacterium tuberculosis Rv2299c, to effectively mature the dendriric cells, and to effectively enhance immune response. CONSTITUTION: A composition for inducing maturation of dendritic cells contains 1-5 microgram/ml of Rv2299c protein derived from Mycobacterium tuberculosis as an active ingredient. A method for inducing maturation of immature dendritic cells comprises: a step of treating Rv2299c to the immature dendritic cells; and a step of culturing the treated dendritic cells for 12-36 hours. The maturation of the immature dendritic cells indicates enhancement of TNF-alpha, IL-12p70, IL-6, and IL-1beta.

    Abstract translation: 目的：提供成熟树突状细胞的方法，以促进使用结核分枝杆菌Rv2299c的未成熟树突状细胞的分化，以有效地成熟树突状细胞，并有效增强免疫应答。 构成：用于诱导树突细胞成熟的组合物含有1-5微克/ ml来自结核分枝杆菌的Rv2299c蛋白作为活性成分。 用于诱导未成熟树突状细胞成熟的方法包括：将Rv2299c处理至未成熟树突状细胞的步骤; 以及培养经处理的树突状细胞12-36小时的步骤。 未成熟树突细胞的成熟表明TNF-α，IL-12p70，IL-6和IL-1beta的增强。

    마이코박테리움 파라튜버큘로시스의 ＭＡＰ１９４８ 단백질을 이용한 수지상 세포의 성숙방법
    3.
    发明公开
    마이코박테리움 파라튜버큘로시스의 ＭＡＰ１９４８ 단백질을 이용한 수지상 세포의 성숙방법 有权
    使用MYCOBACTERIUM PARATUBERCULOSIS MAP1948的感染细胞的成熟方法

    公开(公告)号：KR1020130037884A

    公开(公告)日：2013-04-17

    申请号：KR1020110102394

    申请日：2011-10-07

    Applicant: 충남대학교산학협력단

    Inventor： 신성재 ,  변의홍 ,  김우식 ,  김종석 ,  김화중

    IPC: C12N5/0784 ,  C12N1/38 ,  C07K14/35

    Abstract: PURPOSE: A method for maturing dendritic cells using Mycobacterium paratuberculosis MAP1948 is provided to promote the differentiation of immature dendritic cells and to effectively mature the dendritic cells. CONSTITUTION: A method for maturing dendritic cells using Mycobacterium paratuberculosis MAP1948 comprises: a step of treating immature resin cells with MAP1948; and a step of culturing the cell for 12-36 hours. The immature resin cells are matured through the increase of IL-6, IL-1beta, and IFN-gamma generation.

    Abstract translation: 目的：提供使用分枝杆菌MAP1948成熟树突状细胞的方法，以促进未成熟树突状细胞的分化并有效地成熟树突状细胞。 构成：使用分枝杆菌MAP1948成熟树突状细胞的方法包括：用MAP1948处理未成熟树脂细胞的步骤; 以及培养细胞12-36小时的步骤。 未成熟树脂细胞通过增加IL-6，IL-1β和IFN-γ产生而成熟。

    결핵균의 ＲｐｆＢ 단백질을 유효성분으로 포함하는 수지상 세포의 성숙화 유도용 조성물
    6.
    发明公开
    결핵균의 ＲｐｆＢ 단백질을 유효성분으로 포함하는 수지상 세포의 성숙화 유도용 조성물 有权
    用于诱导包含MYCOBACTERIUM TUBCCOSOS RPFB的感染细胞成熟的组合物

    公开(公告)号：KR1020130092247A

    公开(公告)日：2013-08-20

    申请号：KR1020120013868

    申请日：2012-02-10

    Applicant: 충남대학교산학협력단 ,  연세대학교 산학협력단

    Inventor： 조상래 ,  이혜존 ,  신성재 ,  최한규 ,  변의홍 ,  김우식 ,  김종석 ,  김화중

    IPC: C12N5/0784 ,  C07K14/35

    Abstract: PURPOSE: A maturation inducing composition of dendritic cells is provided to effectively reinforce immune reaction of a body by maturing immature dendritic cells through RpfB protein. CONSTITUTION: A maturation inducing composition of dendritic cells contains RpfB protein as an active ingredient. The RpfB protein is a protein originated from mycobacterium tuberculosis. The RpfB protein is contained with concentration of 0.1-5 micro gram per mili liter. A maturation inducing method of immature dendritic cells is to differentiate into mature dendritic cells.

    Abstract translation: 目的：提供树突状细胞的成熟诱导组合物，通过RpfB蛋白成熟未成熟树突状细胞，有效增强人体的免疫反应。 构成：树突状细胞的成熟诱导组合物含有RpfB蛋白作为活性成分。 RpfB蛋白是起源于结核分枝杆菌的蛋白质。 RpfB蛋白的含量为0.1-5微克/米仑升。 未成熟树突细胞的成熟诱导方法是分化成成熟树突状细胞。

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