항염증 활성을 갖는 리소포스파티딜에탄올아민 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항염증 조성물
    2.
    发明公开
    항염증 활성을 갖는 리소포스파티딜에탄올아민 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항염증 조성물 有权
    具有抗炎活性或药物可接受的盐的赖氨酸衍生物衍生物,其制备方法和含有其作为活性成分的抗炎组合物

    公开(公告)号:KR1020130005770A

    公开(公告)日:2013-01-16

    申请号:KR1020110067380

    申请日:2011-07-07

    CPC classification number: C07F9/10 A23L33/10 A61K8/553 A61K31/6615

    Abstract: PURPOSE: A lysophosphatidylethanolamine derivative and an anti-inflammatory composition containing the same are provided to suppress peritonitis induced by zymosan A in vivo and to enhance anti-inflammatory cytokine(IL-10) generation. CONSTITUTION: A lysophosphatidylethanolamine derivative is denoted by chemical formulas 1-4. A pharmaceutical composition for preventing and treating inflammatory diseases contains the derivative or a pharmaceutically acceptable salt thereof as an active ingredient. The inflammatory diseases are asthma, periodontitis, stomatitis, peritonitis, gastritis, lymphocytic enteritis, arthritis, nephritis, hepatitis, or degenerative diseases. The composition is used as an oral formulation or an injection formulation. A health food for preventing and treating inflammatory diseases contains the derivative or salt thereof as an active ingredient.

    Abstract translation: 目的:提供溶血磷脂酰乙醇胺衍生物和含有它们的抗炎组合物,以抑制由酵母聚糖A体内诱导的腹膜炎并增强抗炎细胞因子(IL-10)的产生。 构成:溶血磷脂酰乙醇胺衍生物由化学式1-4表示。 用于预防和治疗炎性疾病的药物组合物含有作为活性成分的衍生物或其药学上可接受的盐。 炎性疾病是哮喘,牙周炎,口腔炎,腹膜炎,胃炎,淋巴细胞性肠炎,关节炎,肾炎,肝炎或退行性疾病。 该组合物用作口服制剂或注射制剂。 用于预防和治疗炎性疾病的保健食品含有其衍生物或其盐作为活性成分。

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