公开(公告)号：KR100960953B1

公开(公告)日：2010-06-03

申请号：KR1020090081920

申请日：2009-09-01

Applicant: 충남대학교산학협력단

Inventor： 황성주 ,  박준성 ,  조원경 ,  차광호 ,  이병훈

IPC: A61K9/20 ,  A61K31/4184 ,  A61P9/12 ,  A61K9/16

CPC classification number: A61K9/2095 ,  A61K9/2009 ,  A61K9/2013 ,  A61K31/4184

Abstract: PURPOSE: A method for isolating telmisartan is provided to easily produce medicinal product containing telmisartan and to lower cost of medical cost. CONSTITUTION: A telmisartan tablet contains 13-18 weight% of telmisartan, 6-15 weight% of alkali metal hydroxide and meglumine, 4-12 weight% of crystallization retardant, 20-65 weight% of diluents, and 6-32 weight% of solidification forming agent. A method for manufacturing the telmisartan tablet comprises: a step of mixing alkali metal oxide of NaOH or KOH and meglumine in a weight ratio of 1:3-1:10; a step of dissolving the mixture in a mixture solution of purified water and ethanol in weight ratio of 4:1-1:4; a step of adding telmisartan and crystallization retardant; a step of adding solidification forming agent by wet granulation; and a step of drying and molding granule.

Abstract translation: 目的：提供一种隔离替米沙坦的方法，方便生产含替米沙坦的药物，降低医疗成本。 构成：替米沙坦片含有13-18重量％的替米沙坦，6-15重量％的碱金属氢氧化物和葡甲胺，4-12重量％的结晶阻滞剂，20-65重量％的稀释剂和6-32重量％的 凝固成型剂。 一种替米沙坦片剂的制造方法，其特征在于，以1：3-1：10的比例混合NaOH或KOH的碱金属氧化物和葡甲胺的工序; 将混合物溶解在纯化水和乙醇的混合溶液中，重量比为4:1-1:4的步骤; 添加替米沙坦和结晶阻滞剂的步骤; 通过湿法制粒加入固化剂的步骤; 以及干燥和成型颗粒的步骤。