公开(公告)号：KR100554221B1

公开(公告)日：2006-02-22

申请号：KR1020030010800

申请日：2003-02-20

Applicant: 충남대학교산학협력단

Inventor： 송민호 ,  황정환

IPC: C12Q1/00

Abstract: 본 발명은 세포의 증식을 유도하는 신호전달 단백질인 Signal transducer and activator of transcription-3(STAT3)가 RET/PTC 티로신 인산화 효소의 인산화 기질임을 밝히고, 이를 이용하여 in vitro 또는 in vivo에서 RET/PTC의 활성의 측정하는 방법, RET/PTC 활성억제물질을 선별하는 방법 및 RET/PTC 활성억제물질의 성능을 분석하는 방법 등을 제시하는 것이다.
본 발명은 종래 알려진 바와는 다른 방법인 RET/PTC 단백질과 PDK1 단백질의 효소-기질 특이성을 이용함으로써 특이적으로 RET/PTC의 활성을 측정하고 RET/PTC 활성억제물질을 선별할 수 있기 때문에 새로운 항암물질 개발 시스템으로 유용하게 활용할 수 있다.
갑상선, 유두암, RET/PTC, STAT3, 인산화, 티로신

公开(公告)号：KR1020040075272A

公开(公告)日：2004-08-27

申请号：KR1020030010800

申请日：2003-02-20

Applicant: 충남대학교산학협력단

Inventor： 송민호 ,  황정환

IPC: C12Q1/00

Abstract: PURPOSE: A method for identifying an anti-cancer material by using the specific enzyme-substrate relationship between RET/PTC and STAT3 is provided, thereby easily measuring the activity of RET/PTC, and screening the RET/PTC inhibiting materials, so that it can be useful for development of anticancer materials. CONSTITUTION: The method for measuring the activity of RET/PCT comprises using the specific enzyme-substrate relationship between RET/PTC and STAT3(signal transducer and activator of transcription-3), wherein the RET/PTC proteins increase phosphorylation of tyrosine residue of STAT3 in vivo and in vitro; and the RET/PTC proteins are RET/PTC1 and RET/PTC3. The method for identifying an anti-cancer material comprises using the specific enzyme-substrate relationship between RET/PTC and STAT3(signal transducer and activator of transcription-3).

Abstract translation: 目的：提供通过使用RET / PTC和STAT3之间的特定酶 - 底物关系鉴定抗癌材料的方法，从而容易地测量RET / PTC的活性，并筛选RET / PTC抑制物质，使其 可用于开发抗癌材料。 构成：RET / PCT活性测定方法包括使用RET / PTC与STAT3（信号转导和转录激活因子-3）之间的特异性酶 - 底物关系，其中RET / PTC蛋白增加STAT3酪氨酸残基的磷酸化 体内和体外; RET / PTC蛋白是RET / PTC1和RET / PTC3。 用于鉴定抗癌材料的方法包括使用RET / PTC和STAT3（信号转导子和转录激活因子-3）之间的特异酶 - 底物关系。

公开(公告)号：KR1020110040638A

公开(公告)日：2011-04-20

申请号：KR1020100035889

申请日：2010-04-19

Applicant: 한국전자통신연구원 ,  충남대학교산학협력단

Inventor： 박형일 ,  권영미 ,  황정환 ,  강성원

IPC: H04W4/22 ,  H04W72/12 ,  H04W84/10

CPC classification number: H04W72/10 ,  H04W4/90 ,  H04W74/02 ,  H04W74/0816

Abstract: PURPOSE: A method for providing an exclusive slot for urgent data is provided to use the allocated slot as a slot for one urgent data through an inter-node competition method. CONSTITUTION: A superframe includes a beacon interval showing the beginning of superframe, a CAP(Contention Access Period) transmitting a message data through contention and a CFP(Contention Free Period) transmitting a message data without contention. A slot for an urgent data is allocated in the superframe(110). The allotted information of a slot for urgent data is provided to nodes(120).

Abstract translation: 目的：提供一种用于提供紧急数据的专用时隙的方法，通过节点间竞争方法将分配的时隙用作一个紧急数据的时隙。 构成：超帧包括显示超帧开始的信标间隔，通过争用发送消息数据的CAP（争用接入周期）和无竞争的发送消息数据的CFP（无竞争周期）。 在超帧（110）中分配用于紧急数据的时隙。 用于紧急数据的时隙的分配信息被提供给节点（120）。