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公开(公告)号：KR1020120028043A
公开(公告)日：2012-03-22
申请号：KR1020100090002
申请日：2010-09-14
Applicant: 충남대학교산학협력단 , 제주대학교 산학협력단
CPC classification number: C07J63/008 , A23L33/10 , A23V2002/00 , A23V2200/324 , A61K8/63 , A61K31/56
Abstract: PURPOSE: Triterpenoid extracted from steamed acanthopanax koreanum leaves, a producing method thereof, and a use thereof are provided to offer an excellent production inhibition effect of tumor necrosis factor-alpha, interleukin-12, and interleukin-6 to users. CONSTITUTION: Triterpenoid or its salt extracted from steamed acanthopanax koreanum leaves has a structure marked with chemical formula 1. The triterpenoid is extracted from the following steps: steaming the acanthopanax koreanum, and extracting the steamed acanthopanax koreanum leaves with alcohol; suspending the obtained extract, and separating alkyl acetate fractions; and processing the alkyl acetate fractions with the column chromatography.
Abstract translation: 目的：提供蒸气刺五加叶提取的三萜类化合物及其制备方法及其用途，为使用者提供了肿瘤坏死因子-α，白细胞介素-12和白细胞介素-6的良好抑制作用。 构成：从荆棘山楂叶提取的三萜类化合物或其盐具有化学式1的结构。三萜类化合物从以下步骤中提取：蒸煮刺五加，用酒精提取蒸气刺五加叶; 悬浮所得提取物，分离出乙酸甲酯馏分; 并用柱色谱处理乙酸烷基酯馏分。
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公开(公告)号：KR101113202B1
公开(公告)日：2012-02-16
申请号：KR1020100088573
申请日：2010-09-09
Applicant: 충남대학교산학협력단 , 제주대학교 산학협력단
CPC classification number: A61K31/56 , A23L33/10 , A61K8/63 , A61K31/19 , Y10S424/81
Abstract: PURPOSE: A composition of triterpenoid for preventing and treating autoimmune diseases is provided to suppress IL-12, IL-6, and TNF-alpha. CONSTITUTION: A pharmaceutical composition for preventing and treating autoimmune diseases contains triterpenoid of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. In chemical formula 1, R1 is CHO or CH_3; and R2 is O or CH_2. The composition additionally contains a carrier, excipient, disintegrant, sweetener, coating agent, lubricant, flavoring agent, anti-oxidant, buffer solution, diluents, dispersion agent, surfactant, or binder. The pharmaceutical composition is used in the form of a granule, powder, coating tablet, capsule, suppository, syrup, juice, suspension, emulsion, or liquid.
Abstract translation: 目的：提供用于预防和治疗自身免疫性疾病的三萜类化合物，以抑制IL-12，IL-6和TNF-α。 构成：用于预防和治疗自身免疫疾病的药物组合物含有化学式1的三萜化合物或其药学上可接受的盐作为活性成分。 在化学式1中，R1是CHO或CH_3; R2是O或CH_2。 该组合物还含有载体，赋形剂，崩解剂，甜味剂，包衣剂，润滑剂，调味剂，抗氧化剂，缓冲溶液，稀释剂，分散剂，表面活性剂或粘合剂。 药物组合物以颗粒，粉末，包衣片，胶囊，栓剂，糖浆，果汁，悬浮液，乳液或液体的形式使用。
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公开(公告)号：KR101220782B1
公开(公告)日：2013-01-09
申请号：KR1020100090002
申请日：2010-09-14
Applicant: 충남대학교산학협력단 , 제주대학교 산학협력단
Abstract: 본 발명은 화학식 1의 구조를 갖는 트리테르페노이드를 유효성분으로 포함하는 의약, 식품 또는 화장료 조성물에 관한 것이다.
본 발명에 따른 화학식 1의 구조를 갖는 트리테르페노이드는 인터루킨-12 (Interleukin-12), 인터루킨-6 (Interleukin-6) 및 TNF(Tumor necrosis factor)-α 생산 저해 효과가 우수하여, 이들로 인해 유발되는 자가 면역 질환과 패혈증 등의 치료에 유용하게 활용될 수 있다.
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