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    세포 배양용 배지 조성물
    1.
    发明申请
    세포 배양용 배지 조성물 审中-公开
    细胞培养组合物的培养基

    公开(公告)号：WO2018048104A1

    公开(公告)日：2018-03-15

    申请号：PCT/KR2017/008603

    申请日：2017-08-09

    Applicant: 충남대학교산학협력단 ,  한국화학연구원

    Inventor： 강선웅 ,  허강무 ,  조명옥 ,  권보선 ,  문성환

    IPC: C12N5/00 ,  C12N5/079 ,  C12N5/077 ,  C12N5/09 ,  C08B37/08

    Abstract: 본 발명은 세포 배양용 배지 조성물에 관한 것으로, 보다 상세하게는 온도 감응성 고분자인 글리콜 키토산 유도체를 이용하여 세포 증식을 활성화시키는 세포 배양용 배지 조성물에 관한 것이다. 본 발명에 따른 세포 배양용 배지 조성물은 헥사노일 글리콜 키토산(Hexanoyl glycol chitosan: HGC)을 비교적 저농도로 함유하는 것만으로도, 세포의 모폴로지와 생존률에 영향을 미치지 않으면서, 효과적으로 세포 증식률을 향상시킬 수 있다.

    Abstract translation: 本发明涉及细胞培养基组合物，更具体地涉及使用乙二醇壳聚糖衍生物作为热敏聚合物来活化细胞增殖的细胞培养基组合物。 根据本发明的己二醇壳聚糖用于培养细胞培养基的组合物（己酰乙二醇脱乙酰壳多糖：HGC）来只含有相对低浓度的程度，而不影响细胞的形态和生存力，能够有效地改善细胞的增殖

    2-알킬레닐옥시-3-에티닐피리도［2,3-ｂ］피라진 유도체
    5.
    发明公开
    2-알킬레닐옥시-3-에티닐피리도［2,3-ｂ］피라진 유도체 有权
    2-亚苄氧基-3-乙酰基吡啶[2,3-B]吡嗪衍生物

    公开(公告)号：KR1020080004646A

    公开(公告)日：2008-01-10

    申请号：KR1020060063214

    申请日：2006-07-06

    Applicant: 제이더블유중외제약 주식회사 ,  한국화학연구원

    Inventor： 이수진 ,  공영대 ,  전문국 ,  문성환 ,  전기호 ,  김종민 ,  이상휘 ,  이상학 ,  강명주

    IPC: C07D471/04

    CPC classification number: Y02P20/55 ,  C07D471/04

    Abstract: A 2-alkylenyloxy-3-ethynylpyrido[2,3-b]pyrazine derivative is provided to be usefully used as an anticancer agent by using excellent HIF-1alpha gene expression inhibitory activity thereof. A 2-alkylenyloxy-3-ethynylpyrido[2,3-b]pyrazine derivative is represented by the formula(1), where A is selected from the group consisting of alkyl, aryl, and heteroaryl; Y is a single bond, or an alkylene which may be substituted by one to five substituents selected from the group consisting of hydroxy, alkyl-OH, O-alkyl and phenyl; Z is selected from the group consisting of H, halogen, hydroxy, alkyl, alkyl-OH, alkenyl, haloalkyl, O-alkyl, O-haloalkyl, O-aryl, O-heteroaryl, O-heterocycle, O-alkyl-aryl, O-alkyl-heteroaryl, O-alkyl-heterocycle, O-alkyl-NH2, O-alkyl-NH(alkyl), O-alkyl-N(alkyl)2, C(O)alkyl, alkyl-C(O)alkoxy, C(O)NH2, C(O)NH(alkyl), C(O)N(alkyl)2, C(O)NH(aryl), C(O)N(aryl)2, C(O)NH(heteroaryl), C(O)N(heteroaryl)2, C(O)O-alkyl, C(O)O-aryl, C(O)O-heteroaryl, OC(O)-alkyl, OC(O)-aryl, OC(O)heteroaryl, OC(O)NH2, OC(O)NH(alkyl), OC(O)N(alkyl)2, OC(O)N(alkyl)N(alkyl)2, OC(O)NH(aryl), OC(O)NH(heteroaryl), NH2, NH(alkyl), N(alkyl)2, NH(aryl), N(alkyl)(aryl), N(aryl)2, NH(heteroaryl), etc., provided that a compound that the A is methyl, and Y-Z is H is excluded. A pharmaceutical composition for treating and preventing cancer comprises the 2-alkylenyloxy-3-ethynylpyrido[2,3-b]pyrazine derivative or a pharmaceutically acceptable salt thereof.

    Abstract translation: 提供2-亚烷基氧基-3-乙炔基吡啶并[2,3-b]吡嗪衍生物通过使用优异的HIF-1α基因表达抑制活性可用作抗癌剂。 2-烷基氧基-3-乙炔基吡啶并[2,3-b]吡嗪衍生物由式（1）表示，其中A选自烷基，芳基和杂芳基; Y是单键，或可以被一至五个选自羟基，烷基-OH，O-烷基和苯基的取代基取代的亚烷基; Z选自H，卤素，羟基，烷基，烷基-OH，烯基，卤代烷基，O-烷基，O-卤代烷基，O-芳基，O-杂芳基，O-杂环，O-烷基 - 芳基， O-烷基 - 杂芳基，O-烷基 - 杂环，O-烷基-NH 2，O-烷基-NH（烷基），O-烷基-N（烷基）2，C（O）烷基，烷基-C（O） ，C（O）NH 2，C（O）NH（烷基），C（O）N（烷基）2，C（O）NH（芳基），C（O）N（芳基）2，C（O） （O）O-杂芳基，C（O） - 烷基，OC（O） - 烷基，C（O） 芳基，OC（O）杂芳基，OC（O）NH 2，OC（O）NH（烷基），OC（O）N（烷基）2，OC（O） ）NH（芳基），OC（O）NH（杂芳基），NH 2，NH（烷基），N（烷基）2，NH（芳基），N（烷基）（芳基），N（芳基）2，NH ）等，条件是排除A为甲基，YZ为H的化合物。 用于治疗和预防癌症的药物组合物包括2-亚烷基氧基-3-乙炔基吡啶并[2,3-b]吡嗪衍生物或其药学上可接受的盐。

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