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公开(公告)号：KR1020160110864A
公开(公告)日：2016-09-22
申请号：KR1020150035270
申请日：2015-03-13
Applicant: 포항공과대학교 산학협력단
IPC: A61K47/48 , A61K47/02 , A61K47/42 , A61K31/704
CPC classification number: A61K31/704 , A61K9/1617 , A61K9/1658 , A61K9/1682 , A61K9/5169 , A61K38/00 , A61K38/14 , A61K47/52 , A61K47/02 , A61K47/42 , A61K47/62 , A61K47/6923
Abstract: 본발명은홍합접착단백질을기반으로약물전달용 pH-반응성금속-카테콜유도체나노입자, 특히 Fe(Ⅲ)-도파나노입자및 이의제조방법에관한것이다.본발명에따른약물전달용나노입자는홍합접착단백질을기반으로 pH 반응성물질인카테콜유도체-금속복합체, 특히도파-Fe(Ⅲ) 복합체를이용하여제조됨으로써, 생체적합성이우수하고, 표적세포내로쉽고빠르게침투할수 있으며, 산성조건에서적재된약물을배출하므로, 산성환경을갖는특정질환에대해선택적으로약물을전달할수 있는효과가있다.
Abstract translation: 本发明涉及基于贻贝粘合蛋白的药物递送的pH反应性金属 - 儿茶酚衍生物纳米粒子，特别涉及Fe（III）-DOPA纳米粒子及其制造方法。 根据本发明，通过使用邻苯二酚衍生物 - 金属络合物作为贻贝粘合蛋白质的pH反应性物质，特别是DOPA-Fe（III）络合物制造药物递送用纳米粒子，由此具有优异的生物相容性， 以容易且快速的方式渗入靶细胞。 用于药物递送的纳米颗粒释放在酸性条件下携带的药物，从而具有相对于具有酸性环境的特定疾病选择性递送药物的效果。
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公开(公告)号：KR1020140035251A
公开(公告)日：2014-03-21
申请号：KR1020130106599
申请日：2013-09-05
Applicant: 포항공과대학교 산학협력단
CPC classification number: D04H1/4266 , A61L27/22 , A61L27/26 , A61L27/3637 , A61L27/56 , D04H1/4282 , D04H1/728 , D10B2509/00
Abstract: The present invention relates to a nanofibers tissue engineering scaffold comprising mussels coating proteins and Fe3+ ions and a manufacturing method thereof. More specifically, the present invention relates to a nanofibers tissue engineering scaffold which the surface of the nanofibers is coated by bioactive substances, the mussels adhesive proteins is a nanofibers tissue engineering scaffold which more than 20% of the total tyrosine residues are modified to DOPA.
Abstract translation: 本发明涉及包含贻贝涂层蛋白质和Fe3 +离子的纳米纤维组织工程支架及其制造方法。 更具体地，本发明涉及纳米纤维表面被生物活性物质包被的纳米纤维组织工程支架，贻贝粘合蛋白是纳米纤维组织工程支架，其中20％以上的酪氨酸残基被修饰为DOPA。
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公开(公告)号：KR1020140027031A
公开(公告)日：2014-03-06
申请号：KR1020130096424
申请日：2013-08-14
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61L27/52 , A61K9/06 , A61K38/18 , A61K47/42 , A61L2430/00
Abstract: The present invention relates to a mussel adhesive protein-based bioadhesive hydrogel and a manufacturing method thereof. More specifically, to a hydrogel formed by combination of a DOPA (3, 4-dihydroxyphenylalanine) residue included in a mussel adhesive protein and Fe3+ ions. In addition, the present invention relates to a hydrogel formed as a DOPA residue contained in a mussel adhesive protein is oxidized.
Abstract translation: 本发明涉及一种基于贻贝粘合蛋白的生物粘附性水凝胶及其制造方法。 更具体地说，涉及通过组合包含在贻贝粘合蛋白质中的DOPA（3,4-二羟基苯丙氨酸）残基和Fe 3+离子形成的水凝胶。 此外，本发明涉及由贻贝粘合蛋白中所含的DOPA残基形成的水凝胶被氧化。
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Patent Agency Ranking
公开(公告)号：KR1020130021951A
公开(公告)日：2013-03-06
申请号：KR1020110084543
申请日：2011-08-24
Applicant: 포항공과대학교 산학협력단
CPC classification number: C12N5/0068 , B82Y5/00 , C07K14/43504 , C12N5/0654 , C12N2533/10 , C12N2533/40 , C12N2533/50 , C12N2533/70 , C12N2533/80 , C12N2537/00
Abstract: PURPOSE: Surface immobilization of various functional biomolecules is provided to conveniently implement an artificial extracellular substrate. CONSTITUTION: Surface immobilization of various functional biomolecules is as follows. A tissue engineering supporter comprises mussel adhesive protein and bioactive substances adhered to the mussel adhesive protein. The mussel adhesive protein and bioactive substances are coated on the surface of metal. The mussel adhesive protein is protein consisting of amino acid sequence with sequence number 4.
Abstract translation: 目的：提供各种功能性生物分子的表面固定以方便地实施人造细胞外基质。 构成：各种功能性生物分子的表面固定如下。 组织工程支持物包括贻贝粘合蛋白和附着于贻贝粘合蛋白的生物活性物质。 贻贝粘合蛋白和生物活性物质涂在金属表面。 贻贝粘蛋白是由序列号4的氨基酸序列组成的蛋白质。
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公开(公告)号：KR101722503B1
公开(公告)日：2017-04-04
申请号：KR1020150035270
申请日：2015-03-13
Applicant: 포항공과대학교 산학협력단
IPC: A61K47/48 , A61K47/02 , A61K47/42 , A61K31/704
CPC classification number: A61K31/704 , A61K9/1617 , A61K9/1658 , A61K9/1682 , A61K9/5169 , A61K38/00 , A61K38/14
Abstract: 본발명은홍합접착단백질을기반으로약물전달용 pH-반응성금속-카테콜유도체나노입자, 특히 Fe(Ⅲ)-도파나노입자및 이의제조방법에관한것이다.본발명에따른약물전달용나노입자는홍합접착단백질을기반으로 pH 반응성물질인카테콜유도체-금속복합체, 특히도파-Fe(Ⅲ) 복합체를이용하여제조됨으로써, 생체적합성이우수하고, 표적세포내로쉽고빠르게침투할수 있으며, 산성조건에서적재된약물을배출하므로, 산성환경을갖는특정질환에대해선택적으로약물을전달할수 있는효과가있다.
Abstract translation: 本发明涉及用于基于贻贝粘附蛋白的药物递送的pH响应性金属 - 儿茶酚衍生物纳米颗粒，尤其是Fe（III） - 多巴纳米颗粒及其制备方法。 通过使用基于贻贝粘附蛋白的儿茶酚衍生物 - 金属络合物，尤其是多巴-Fe（III）复合物，可以容易且快速地渗透到靶细胞中， 由于药物被排出，所以具有选择性地将药物递送至具有酸性环境的特定疾病的效果。
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公开(公告)号：KR101384746B1
公开(公告)日：2014-04-14
申请号：KR1020110084543
申请日：2011-08-24
Applicant: 포항공과대학교 산학협력단
CPC classification number: C12N5/0068 , B82Y5/00 , C07K14/43504 , C12N5/0654 , C12N2533/10 , C12N2533/40 , C12N2533/50 , C12N2533/70 , C12N2533/80 , C12N2537/00
Abstract: 본 발명은 홍합 접착 단백질을 이용하여 다양한 기능성 생리활성물질들을 별도의 물리화학적 처리과정 없이 다양한 표면에 고정화 또는 코팅시키는 기술에 관한 것이다. 보다 구체적으로, 본 발명은 홍합 접착 단백질을 이용하여 다양한 기능성 생리활성물질들을 나노 섬유 및 금속 지지체 표면에 코팅하여 제조된 조직공학용 인공 세포외 기질을 포함한 기능성 지지체(scaffold) 및 이의 제조방법에 관한 것이다.
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