公开(公告)号：KR1020140050465A

公开(公告)日：2014-04-29

申请号：KR1020120116926

申请日：2012-10-19

Applicant: 포항공과대학교 산학협력단

Inventor： 박재성 ,  김준호 ,  라이언토마스데이비스

IPC: C12Q1/24 ,  C12M1/12 ,  G01N33/574 ,  G01N35/08

CPC classification number: G01N33/574 ,  B01L3/502753 ,  C12P19/34 ,  C12Q1/68 ,  G01N2001/4088

Abstract: The present invention relates to an apparatus for isolation of extracellular vesicles from body fluid, and more specifically, to a device comprising a channel formed on a microchip and a porous polymer monolith filter connected to the channel. A device of the present invention can be used for obtaining nucleic acid information in vesicles needed for diagnosis of diseases such as cancers, etc. by a noninvasive method. By using the device of the present invention, it is possible to isolate and purify a large amount of vesicles in a short period of time from a small amount of body fluid sample thereby being used for clinical diagnosis. Therefore, it is expected to be significantly used for research using vesicles and diagnosis of diseases such as cancers, etc.

Abstract translation: 本发明涉及一种用于从体液分离细胞外囊泡的装置，更具体地说，涉及一种装置，其包括形成在微芯片上的通道和连接到通道的多孔聚合物整体滤清器。 本发明的装置可用于通过非侵入性方法获得诊断疾病如癌症等所需的囊泡中的核酸信息。 通过使用本发明的装置，可以在短时间内从少量的体液样品中分离并净化大量的囊泡，从而用于临床诊断。 因此，预计将显着用于使用囊泡的研究和诸如癌症等疾病的诊断。