公开(公告)号：KR1020130021920A

公开(公告)日：2013-03-06

申请号：KR1020110084487

申请日：2011-08-24

Applicant: 포항공과대학교 산학협력단

Inventor： 김윤근 ,  고용송 ,  문형근 ,  강칠성

IPC: A61K35/74 ,  A23L1/30 ,  A61K8/99

CPC classification number: A61K35/74 ,  A23L33/135 ,  A23V2200/324 ,  A61K8/99

Abstract: PURPOSE: A composition containing an extracellular vesicle derived from Akkermansia muciniphila or Bacteroides acidifaciens is provided to suppress inflammatory diseases. CONSTITUTION: A composition for preventing or treating inflammatory diseases contains an extracellular vesicle derived from Akkermansia muciniphila or Bacteroides acidifaciens. The extracellular vesicle is naturally or artificially secreted from Akkermansia muciniphila or Bacteroides acidifaciens. The average diameter of the extracellular vesicle is 20-800 nm. The composition is a pharmaceutical composition.

Abstract translation: 目的：提供一种含有源自Akkermansia muciniphila或致病杆菌的细胞外囊泡的组合物以抑制炎性疾病。 构成：用于预防或治疗炎性疾病的组合物含有衍生自Akkermansia muciniphila或拟杆菌属的发酵细胞外泡。 细胞外囊泡是天然的或人工分泌的Akkermansia muciniphila或拟杆菌属。 细胞外囊泡的平均直径为20-800nm。 组合物是药物组合物。

公开(公告)号：KR1020110020169A

公开(公告)日：2011-03-02

申请号：KR1020100071240

申请日：2010-07-23

Applicant: 포항공과대학교 산학협력단

Inventor： 김윤근 ,  전성규 ,  문형근 ,  고용송

IPC: A61K39/395 ,  A61K31/7076 ,  A61K38/20 ,  A61P11/06

Abstract: PURPOSE: A combination formulation for effectively preventing or treating IL-17-mediated inflammatory diseases by combined administration of drugs is provided. CONSTITUTION: A combined formulation for preventing or treating IL-17-mediated inflammatory diseases contains: an adenosine generation promoter, Th2 cytokine inhibitor or signal transduction inhibitor thereof, and a drug which suppresses uric acid generation or promoting uric acid degradation. The adenosine generation promoter is aspirin, derivative or salt thereof. The Th2 cytokine is IL-4, IL-5, IL-9, or IL-13.

Abstract translation: 目的：提供通过联合给予药物有效预防或治疗IL-17介导的炎性疾病的组合制剂。 构成：用于预防或治疗IL-17介导的炎性疾病的组合制剂包含：腺苷产生启动子，Th2细胞因子抑制剂或其信号转导抑制剂，以及抑制尿酸生成或促进尿酸降解的药物。 腺苷产生促进剂是阿司匹林，其衍生物或其盐。 Th2细胞因子是IL-4，IL-5，IL-9或IL-13。

公开(公告)号：KR101704815B1

公开(公告)日：2017-02-09

申请号：KR1020100071240

申请日：2010-07-23

Applicant: 포항공과대학교 산학협력단

Inventor： 김윤근 ,  전성규 ,  문형근 ,  고용송

IPC: A61K39/395 ,  A61K31/7076 ,  A61K38/20 ,  A61P11/06

Abstract: 본발명은아데노신생성촉진제, IL-4, IL-5, IL-9, IL-13 등의 Th2 사이토카인억제제또는이의신호전달억제제, 및요산의생성억제또는분해촉진약물을포함하는, IL-17에의해매개되는염증질환의예방용또는치료용조합제제에관한것이다. 또한본 발명은아데노신생성촉진제, Th2 사이토카인억제제또는이의신호전달억제제, 및요산의생성억제또는분해촉진약물을병합투여함으로써 IL-17에의해발생또는악화되는비호산구성또는호중구성호흡기염증질환, IL-17에의한호중구성염증을특징으로하는소화기질환, 혈관/대사질환, 피부질환, 골관절질환, 뇌신경질환, 및 IL-17에의한호중구성염증의합병증으로생기는폐암, 위암, 대장암등을예방또는치료하는방법에관한것이다.

Abstract translation: 目的：提供通过联合给予药物有效预防或治疗IL-17介导的炎性疾病的组合制剂。 构成：用于预防或治疗IL-17介导的炎性疾病的组合制剂包含：腺苷产生启动子，Th2细胞因子抑制剂或其信号转导抑制剂，以及抑制尿酸生成或促进尿酸降解的药物。 腺苷产生促进剂是阿司匹林，其衍生物或其盐。 Th2细胞因子是IL-4，IL-5，IL-9或IL-13。

公开(公告)号：KR1020130141878A

公开(公告)日：2013-12-27

申请号：KR1020120064958

申请日：2012-06-18

Applicant: 포항공과대학교 산학협력단

Inventor： 김윤근 ,  고용송 ,  전성규 ,  문형근

IPC: A61K38/18 ,  A61P35/00 ,  A61P31/04

Abstract: The present invention relates to an immunity reinforcing composition which contains recombined fibrobalst growth factor-2 (FGF2) as an active ingredient and is capable of containing antigens. The composition of the present invention can be used as a pharmaceutical composition and a vaccine composition for preventing or treating: infectious diseases caused by virus, bacteria, fungi, or protozoa; or inflammation diseases caused by extracellular endoplasmic reticulum secreted from the bacteria, fungi, or protozoa.

Abstract translation: 本发明涉及含有重组的纤维素生长因子-2（FGF2）作为活性成分并能够含有抗原的免疫增强组合物。 本发明的组合物可以用作药物组合物和用于预防或治疗由病毒，细菌，真菌或原生动物引起的感染性疾病的疫苗组合物; 或由细菌，真菌或原生动物分泌的细胞外质网引起的炎症疾病。

公开(公告)号：KR1020160140565A

公开(公告)日：2016-12-07

申请号：KR1020160162908

申请日：2016-12-01

Applicant: 포항공과대학교 산학협력단

Inventor： 김윤근 ,  고용송 ,  문형근 ,  강칠성

IPC: A61K35/74 ,  A23L33/135 ,  A61K8/99

CPC classification number: A61K35/74 ,  A23L33/135 ,  A23V2200/324 ,  A61K8/99

Abstract: 본발명은또는유래세포밖소포체를유효성분으로함유하는염증성질환의치료또는예방용조성물에관한것이다. 상기조성물은함유된세포밖소포체로인하여염증성질환을억제할수 있으며, 이에따라염증성질환의예방또는치료를위한약학적조성물, 식품조성물, 및화장료조성물등으로이용될수 있다. 또한본 발명은포유동물의체내또는분비물에서분리된세포밖소포체중에서또는유래세포밖소포체를정량함으로써염증성질환의발생또는그 경과를진단하는방법에관한것이다.