公开(公告)号：KR1020130136862A

公开(公告)日：2013-12-13

申请号：KR1020120060594

申请日：2012-06-05

Applicant: 포항공과대학교 산학협력단

Inventor： 김원종 ,  손세진 ,  이두환

IPC: A61K47/48 ,  A61K47/42 ,  A61K47/30 ,  A61K31/7105

CPC classification number: A61K47/59 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/42 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S514/912 ,  Y10S514/925

Abstract: The present invention relates to a complex for nucleic acid delivery comprising a biopolymer whereon a target peptide is combined and poly nucleic acid and, more desirably, the provision of the complex for nucleic acid delivery wherein the poly nucleic acid and a biopolymer which is produced by combination of a cationic polymer connected with biodegradable bond and the target peptide are combined. The complex for nucleic acid delivery according to the present invention comprises a biodegradable polymer, a target substance, and the poly nucleic acid, thereby selectively delivering nucleic acid to target cells like cancer cells and being degradable in the cells. Accordingly, the complex for delivering nucleic acid to the cell according to the present invention has useful effect in minimizing toxicity due to degradability in the cells as well as the amount of therapeutic nucleic acid induced into normal cells by the use of poly nucleic acid in case of being used for gene therapies against various diseases, thereby maximizing the utilization rate of the nucleic acid injected into the body.

Abstract translation: 本发明涉及用于核酸递送的复合物，其包含其中组合目标肽的生物聚合物，并且更理想地，提供用于核酸转运的复合物，其中所述多核酸和生物聚合物由 将与生物可降解键连接的阳离子聚合物和靶肽的组合组合。 根据本发明的用于核酸递送的复合物包含可生物降解的聚合物，靶物质和多核酸，从而选择性地将核酸递送至诸如癌细胞的靶细胞并且可在细胞中降解。 因此，根据本发明的用于将核酸递送至细胞的复合物在由于细胞中的降解性引起的毒性以及通过使用多核酸在正常细胞中诱导的治疗性核酸的量的最小化方面具有有效的作用 用于针对各种疾病的基因治疗，从而最大化注射到体内的核酸的利用率。