-
公开(公告)号：KR100455662B1
公开(公告)日：2004-11-06
申请号：KR1020020013809
申请日：2002-03-14
Applicant: 학교법인 포항공과대학교
CPC classification number: C07F17/02
Abstract: Novel aminocyclopentadienyl ruthenium complex is useful as a catalyst in the racemization of a chiral compound.
Abstract translation: 新型氨基环戊二烯基钌配合物可用作手性化合物外消旋化的催化剂。
-
公开(公告)号：KR1020030074851A
公开(公告)日：2003-09-22
申请号：KR1020020013832
申请日：2002-03-14
Applicant: 학교법인 포항공과대학교
IPC: C07C29/00
CPC classification number: C12P41/004
Abstract: PURPOSE: A method for separating chiral compounds by using an aminocyclopentadienyl ruthenium catalyst is provided, to allow the chiral compounds to be separated at a low temperature by using a small amount of an acyl donor material and an enzyme catalyst. CONSTITUTION: The method comprises the step of reacting chiral compounds in a solvent in the presence of an aminocyclopentadienyl ruthenium complex represented by the formula 1 as a metal catalyst, an enzyme catalyst, an acyl donor material and a base, wherein R1's are independently a substituted or unsubstituted phenyl group or an alkyl group of C1-C5; R2 is H, a substituted or unsubstituted phenyl group, a substituted or unsubstituted alkyl group of C1-C5, a cycloalkyl group of C3-C5, an alkenyl group of C2-C5 or an alkynyl group of C2-C5; X, Y and Z are a substituent and are H, a carbonyl group, a phosphine group or a halogen atom if substituted; and the substituent of the phenyl group is one or two selected from the group consisting of an alkyl group of C1-C5, a cycloalkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a halogen atom, a nitro group, a nitroso group, an amine group, an amide group, a hydroxyl group, a thiol group and a sulfide group, and the substituent of the alkyl group is one, two or three selected from the group consisting of an aryl group, an alkoxy group of C1-C5, a halogen atom, a nitro group, a nitroso group, an amine group, an amide group, a hydroxyl group, a thiol group and a sulfide group. Preferably the chiral compounds are a chiral secondary alcohol represented by the formula 3.
Abstract translation: 目的：提供通过使用氨基环戊二烯基钌催化剂分离手性化合物的方法，以通过使用少量酰基供体材料和酶催化剂在低温下分离手性化合物。 方案：该方法包括在溶剂中在由式1表示的氨基环戊二烯基钌络合物作为金属催化剂，酶催化剂，酰基供体材料和碱的存在下使手性化合物反应的步骤，其中R 1独立地是取代的 或未取代的苯基或C1-C5的烷基; R2是H，取代或未取代的苯基，C1-C5的取代或未取代的烷基，C3-C5的环烷基，C2-C5的烯基或C2-C5的炔基; X，Y和Z是取代基，如果被取代，是H，羰基，膦基或卤素原子; 苯基的取代基是选自C1-C5烷基，环烷基，烯基，炔基，烷氧基，卤素原子，硝基，硝基等的一个或两个 亚硝基，胺基，酰胺基，羟基，硫醇基和硫醚基，所述烷基的取代基是选自以下的一种，两种或三种：芳基，烷氧基 C1-C5，卤素原子，硝基，亚硝基，胺基，酰胺基，羟基，硫醇基和硫醚基。 优选地，手性化合物是由式3表示的手性仲醇。
-
公开(公告)号：KR100644165B1
公开(公告)日：2006-11-10
申请号：KR1020020013832
申请日：2002-03-14
Applicant: 학교법인 포항공과대학교
IPC: C07C29/00
CPC classification number: C12P41/004
Abstract: 본 발명은 키랄 알콜을 동적 속도론적으로 분할하는 방법에 관한 것으로서, 구체적으로는 하기 화학식 1의 아미노시클로펜타디에닐 루테늄을 금속 촉매로 사용하여 키랄 알콜을 효소 촉매, 아실 주게 물질, 첨가제 및 염기의 존재 하에 용매 중에서 반응시켜 각각의 에난티오머로 분할하는 방법에 관한 것이다. 본 발명에 따르면 낮은 온도에서 반응이 가능하고 알케닐 아세테이트를 아실 주게 물질로 사용가능하며, 따라서 적은 량의 아실 주게 물질 및 효소를 사용하여서도 생성물의 분리가 용이하므로 공업적, 경제적으로 훨씬 유리하고 수소매개체로서의 케톤을 사용하지 않는 등의 장점이 있다.
상기 식에서, R
1 은 독립적으로 페닐기, 치환된 페닐기 또는 C
1-5 알킬기를 나타내고, R
2 는 수소, 페닐기, 치환된 페닐기, C
1-5 알킬 또는 치환된 C
1-5 알킬기, C
3-5 시클로알킬기, C
2-5 알케닐기, C
2-5 알키닐기를 나타내며, X, Y 및 Z는 임의의 치환체로서, 치환되는 경우 각각 독립적으로 수소, 카르보닐기, 포스핀기 또는 할로겐 원자이다.-
公开(公告)号：KR1020030073987A
公开(公告)日：2003-09-19
申请号：KR1020020013809
申请日：2002-03-14
Applicant: 학교법인 포항공과대학교
CPC classification number: C07F17/02
Abstract: PURPOSE: Provided is an aminocyclopentadienyl ruthenium complex compound which rapidly racemizes chirality alcohol at ambient temperature without requiring any hydrogen medium. CONSTITUTION: A ruthenium complex is expressed by the formula 1. In the formula 1, R1 indicates phenyl group, substituted phenyl group or C1-5 alkyl group, and R2 indicates hydrogen, phenyl group, substituted phenyl group, C1-5 alkyl or substituted C1-5 alkyl group, C3-5b cycloalkyl group, C2-5 alkenyl group, or C2-5 alkynyl group. X, Y and Z are arbitrary substitutes, and with the case of substitution, indicate hydrogen, carbonyl group and phosphine group or halogen atom, respectively. The substitute of the phenyl group is formed with one or two elements selected from the group consisting of C1-5 alkyl group, cycloalkyl group, alkenyl group, alkynyl group, alkoxy group, halogen atom, nitro group, nitroso group, amine group, amide group, hydroxyl group, thiol group, and sulfide group. The substitute of the alkyl group is formed with one to three elements selected from the group consisting of aryl group, C1-5 alkoxy group, halogen atom, nitro group, nitroso group, amine group, amide group, hydroxyl group, thiol group, and sulfide group.
Abstract translation: 目的：提供一种氨基环戊二烯基钌络合物，其在环境温度下快速消旋手性酒精，而不需要任何氢介质。 构成：钌络合物由式1表示。在式1中，R 1表示苯基，取代的苯基或C 1-5烷基，R 2表示氢，苯基，取代的苯基，C 1-5烷基或取代的 C 1-5烷基，C 3-5环烷基，C 2-5烯基或C 2-5炔基。 X，Y和Z是任意的取代基，取代的情况分别表示氢，羰基和膦基或卤素原子。 苯基的取代基由选自C 1-5烷基，环烷基，烯基，炔基，烷氧基，卤素原子，硝基，亚硝基，胺基，酰胺中的一种或两种元素形成 基团，羟基，硫醇基和硫醚基。 烷基的取代基由选自芳基，C 1-5烷氧基，卤素原子，硝基，亚硝基，胺基，酰胺基，羟基，硫醇基中的1〜3个元素形成， 硫化物组。
-
-
-
Search Results
4
records
(took 0.019 seconds)
