公开(公告)号：KR100829122B1

公开(公告)日：2008-05-13

申请号：KR1020060122415

申请日：2006-12-05

Applicant: 한국과학기술연구원

Inventor： 김동현 ,  유혜현 ,  이민우 ,  김남선

IPC: A61K36/232 ,  A61K31/37 ,  A61P35/00

CPC classification number: A61K31/37 ,  A61K36/232

Abstract: A composition comprising the extract of Angelica gigas Nakai or coumarin based compounds isolated therefrom is provided to inhibit activity of CYP2A6 enzyme as a major enzyme causing lung cancer, so that the composition is useful for prevention of lung cancer. A composition for prevention of lung cancer comprises the extract of Angelica gigas Nakai or coumarin based compounds isolated therefrom represented by the formula(1) or formula(2) wherein R1 is hydroxyl group or C2-C10 alkenylcarbonyloxy group; R2 and R3 are each independently hydrogen, C1-C5 alkyl group or C1-C5 alkyl group having hydroxyl group; R4 is hydrogen, C1-C5 alkoxy or C2-C5 alkenyloxy group; n is 0 or 1; and R5 is linear or branched C2-C10 alkenyl group, wherein the coumarin based compounds include decursin represented by the formula(3), decursinol angelate represented by the formula(5), 7-dimethyl suberosine represented by the formula(6) or isoimperatorin represented by the formula(7).

Abstract translation: 提供了包含从其中分离出的当归提取物或基于香豆素的化合物的组合物以抑制CYP2A6酶作为引起肺癌的主要酶的活性，使得该组合物可用于预防肺癌。 用于预防肺癌的组合物包括由式（1）或式（2）表示的其中R 1为羟基或C 2 -C 10烯基羰基氧基的分离自其的分离的当归粉末或香豆素基化合物的提取物; R2和R3各自独立地为氢，C1-C5烷基或具有羟基的C1-C5烷基; R4是氢，C1-C5烷氧基或C2-C5烯氧基; n为0或1; 其中所述香豆素类化合物包括由式（3）表示的前胡素，由式（5）表示的当归酸前胡酯，由式（6）表示的7-二甲基异亮氨酸或异精氨酸 由式（7）表示。