公开(公告)号：KR101342035B1

公开(公告)日：2013-12-16

申请号：KR1020060055307

申请日：2006-06-20

Applicant: 한국과학기술연구원

Inventor： 류재천 ,  김연정 ,  김미순

IPC: C12Q1/68 ,  G01N33/53

Abstract: 본발명은신장독성및 부작용유발약물검색용바이오마커및 이를이용한검색방법에관한것으로, 구체적으로다양한신장독성유발약물에공통적으로유전자발현이증가또는감소하는바이오마커및 이를이용한신장독성및 부작용유발약물검색방법에관한것이다. 본발명의바이오마커는 DNA 마이크로어레이칩을통하여선별된반응유전자들을바이오마커로이용하여새로운신장독성및 부작용의위험성을지닌약물또는화학물질을모니터링및 판정하는데유용하게사용될수 있으며, 신장독성을일으키는작용기작을규명하는도구로이용될수 있다.

公开(公告)号：KR1020070120709A

公开(公告)日：2007-12-26

申请号：KR1020060055307

申请日：2006-06-20

Applicant: 한국과학기술연구원

Inventor： 류재천 ,  김연정 ,  김미순

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/6837 ,  G01N33/5308

Abstract: A biomarker is provided to be usefully used for monitoring and determining drugs or chemical materials having new nephrotoxicity and the danger of side effects, thereby being employed as a tool for investigating the action mode causing the nephrotoxicity. A biomarker for screening nephrotoxicity and side effect-inducing drugs comprises a gene selected from the group consisting of: Genebank XM_498383, Genebank AK001361, Genebank AJ002535, Genebank AK095253, Genebank AK026909, Genebank CR612719, Genebank NM_138417, Genebank CR601067, Genebank AK074052, Genebank XM_039495, Genebank BC067751, Genebank BM555452, Genebank AK025974, Genebank NM_152392, Genebank CR613579, Genebank NM_031298, Genebank BU673968, Genebank D67025, Genebank BC040191, Genebank XM_371569, Genebank NM_015946, Genebank BX537620, Genebank NM_005203, Genebank BC004102, Genebank AB075871, Genebank NM_005310, Genebank NM_173160, Genebank XM_499262, Genebank NM_080542, Genebank AY203954, Genebank NM_001005190, Genebank NM_005247, Genebank C033515, Genebank NM_000134, Genebank BC051890, Genebank Y008294, Genebank NM_014323, Genebank NM_001215, Genebank AY706204, Genebank NM_001004703, Genebank NM_002409, Genebank AK094580, Genebank NM_002918, Genebank AF097935, Genebank NM_012110, Genebank NM_001001524, Genebank BE889572, Genebank BX640959, Genebank AK122912, Genebank XM_495909, Genebank NM_020458, Genebank NM_145202, Genebank AF307451, Genebank AK024144, Genebank AB040955, Genebank AL833764, Genebank AY129013, Genebank AK096289, Genebank BM542003, Genebank AB018270, Genebank BC073828, Genebank AF279145, Genebank AY358993, Genebank BG167195, Genebank XM_498695, Genebank XM_373266, Genebank AK096265, Genebank XM_378608, Genebank AW575256, Genebank NM_001010867, Genebank AK023662, Genebank XM_290629, Genebank AL136662 and Genebank BC025741. The nephrotoxicity and side effect-inducing drug is selected from group consisting of amphotericin B, cisplatin and gentamicin.

Abstract translation: 提供了一种有效地用于监测和确定具有新的肾毒性和副作用危险的药物或化学物质的生物标志物，从而被用作调查引起肾毒性的作用模式的工具。 用于筛选肾毒性和副作用诱导药物的生物标志物包含选自以下的基因：Genebank XM_498383，Genebank AK001361，Genebank AJ002535，Genebank AK095253，Genebank AK026909，Genebank CR612719，Genebank NM_138417，Genebank CR601067，Genebank AK074052，Genebank XM_039495 ，Genebank BC067751，Genebank BM555452，Genebank AK025974，Genebank NM_152392，Genebank CR613579，Genebank NM_031298，Genebank BU673968，Genebank D67025，Genebank BC040191，Genebank XM_371569，Genebank NM_015946，Genebank BX537620，Genebank NM_005203，Genebank BC004102，Genebank AB075871，Genebank NM_005310，Genebank 使用Genebank NM_080542，Genebank NM_080542，Genebank NM_080542，Genebank NM_005247，Genebank NM_001005190，Genebank NM_005247，Genebank C033515，Genebank NM_000134，Genebank BC051890，Genebank Y008294，Genebank NM_014323，Genebank NM_001215，Genebank AY706204，Genebank NM_001004703，Genebank NM_002409，Genebank AK094580，Genebank NM_002918， Genebank AF097935，Genebank NM_01 2198，Genebank NM_001001524，Genebank NM_001001524，Genebank BE889572，Genebank BX640959，Genebank AK122912，Genebank XM_495909，Genebank NM_020458，Genebank NM_145202，Genebank AF307451，Genebank AK024144，Genebank AB040955，Genebank AL833764，Genebank AY129013，Genebank AK096289，Genebank BM542003，Genebank AB018270，Genebank BC073828， 基因库AF279145，Genebank AY358993，Genebank BG167195，Genebank XM_498695，Genebank XM_373266，Genebank AK096265，Genebank XM_378608，Genebank AW575256，Genebank NM_001010867，Genebank AK023662，Genebank XM_290629，Genebank AL136662和Genebank BC025741。 肾毒性和副作用诱导药物选自两性霉素B，顺铂和庆大霉素。