公开(公告)号：KR100497258B1

公开(公告)日：2005-06-28

申请号：KR1020030003320

申请日：2003-01-17

Applicant: 한국과학기술연구원 ,  대화제약 주식회사

Inventor： 정혜선 ,  정서영 ,  권익찬 ,  박재형 ,  정진욱 ,  김영만 ,  이인현

IPC: A61K9/107

Abstract: 본 발명은 동맥색전술에 이용가능한 에멀젼으로 조성가능한 파클리탁셀 혼합 조성물, 그의 유중수형 (water-in-oil (w/o)) 에멀젼 조성물 및 그 제조방법에 관한 것이다. 본 발명의 에멀젼 제형은 수용성 및 지용성 약제를 추가로 포함할 수 있으므로 항암제 복합제등 복합제형을 용이하게 제조할 수 있다.

公开(公告)号：KR1020040076387A

公开(公告)日：2004-09-01

申请号：KR1020030011718

申请日：2003-02-25

Applicant: 한국과학기술연구원

Inventor： 이강봉 ,  박현미 ,  김영만 ,  류재천

IPC: G01N30/00

Abstract: PURPOSE: Provided is an improved solid phase microextraction(SPME) fiber performing an extraction, concentration, and derivatization simultaneously thereon. A method for analyzing an alkylphenol and a bisphenol-A in a water sample by using the SPME fiber is also provided. CONSTITUTION: The SPME fiber is produced by soaking a SPME fiber in a mixture, comprising bis(trimethyl silyl)trifluoro acetamide(BSTFA) and trimethyl chloro silane(TMCS) in the weight ratio of 100:1, for 30min to 2hrs to absorb the BSTFA into the SPME fiber. And the method for analyzing the alkylphenol and the bisphenol-A comprises the steps of: bring the SPME fiber into contact with the water sample to absorb the alkylphenol and the bisphenol-A into the fiber; separating the fiber and then analyzing by using a gas chromatography/mass spectrometer(GC/MS).

Abstract translation: 目的：提供一种改进的固相微萃取（SPME）纤维，在其上同时进行萃取，浓缩和衍生。 还提供了通过使用SPME纤维分析水样品中的烷基酚和双酚A的方法。 构成：SPME纤维通过将SPME纤维以100（重量比）的双（三甲基甲硅烷基）三氟乙酰胺（BSTFA）和三甲基氯硅烷（TMCS））混合在一起混合30分钟至2小时来吸收 BSTFA进入SPME纤维。 并且分析烷基酚和双酚A的方法包括以下步骤：使SPME纤维与水样接触以将烷基酚和双酚A吸收到纤维中; 分离纤维，然后使用气相色谱/质谱仪（GC / MS）进行分析。

公开(公告)号：KR1020030023369A

公开(公告)日：2003-03-19

申请号：KR1020010056536

申请日：2001-09-13

Applicant: 한국과학기술연구원 ,  대화제약 주식회사

Inventor： 정혜선 ,  정서영 ,  권익찬 ,  박재형 ,  정진욱 ,  김영만 ,  이인현

IPC: A61K31/335

CPC classification number: A61K49/0452 ,  A61K9/0019 ,  A61K31/337 ,  A61K47/44

Abstract: PURPOSE: A process of preparing a paclitaxel oily composition for chemoembolization by adding paclitaxel to an oily contrast medium and then agitating is provided. The composition is easy to manufacture and sterilize and more physiochemically stable than conventional adriamycin/lipiodol preparation. CONSTITUTION: The paclitaxel oily composition is prepared by mixing 0.0001 to 10mg paclitaxel with 1ml oily contrast medium under sterilization conditions, agitating at room temperature and then sterilized by gamma ray. The oily contrast medium is iodized oil having an iodine content of 30 to 50% selected from iodized poppy seed oil, ethiodol and iodized soybean oil. The composition optionally contains 0.1 to 1ml animal oil such as squalane, vegetable oil such as soybean oil or a mixture thereof, based on 1ml oily contrast medium.

Abstract translation: 目的：提供通过将紫杉醇加入到油性造影剂中然后搅拌来制备用于化学栓塞的紫杉醇油性组合物的方法。 该组合物易于制造和消毒，并且比常规阿霉素/碘油制剂更具生理化学稳定性。 构成：通过在灭菌条件下将0.0001至10mg紫杉醇与1ml油性造影剂混合制备紫杉醇油性组合物，在室温下搅拌，然后用γ射线灭菌。 油性造影剂是选自碘化罂粟籽油，乙醇碘化物和碘化大豆油中碘含量为30〜50％的碘化油。 基于1ml油性造影剂，组合物任选地含有0.1至1ml动物油如角鲨烷，植物油如大豆油或其混合物。

公开(公告)号：KR100275790B1

公开(公告)日：2000-12-15

申请号：KR1019980022953

申请日：1998-06-18

Applicant: 한국과학기술연구원

Inventor： 이강봉 ,  박현미 ,  김영만

IPC: B01D53/02 ,  B01D53/04

Abstract: 게 껍질 분말로 이루어진 유독한 휘발성 유기 화합물 농축용 흡착제 및 그의 제조방법. 본 발명의 게 껍질 흡착제는 특히 대기 중 휘발성 유기 화합물의 기체 크로마토그래피 분석에 앞서 이들 유기 화합물을 농축시키는데 특히 유용하게 이용될 수 있다. 본 발명의 흡착제는 자연 중에 산재해 있는 게 껍질을 원료로 함에 따라 제조 비용이 극히 저렴하면서도 검출한계 및 다양한 유기화합물 분석에의 활용도 측면에서도 기존의 흡착제에 비해 손색이 없고 사용방법도 간편하여 산업적으로 매우 유용하다.

公开(公告)号：KR1020040066300A

公开(公告)日：2004-07-27

申请号：KR1020030003320

申请日：2003-01-17

Applicant: 한국과학기술연구원 ,  대화제약 주식회사

Inventor： 정혜선 ,  정서영 ,  권익찬 ,  박재형 ,  정진욱 ,  김영만 ,  이인현

IPC: A61K9/107

CPC classification number: A61K9/107 ,  A61K31/337 ,  A61K45/06 ,  A61K47/24 ,  A61K47/44 ,  A61K49/0438

Abstract: PURPOSE: A paclitaxel mixed composition, its water-in-oil type emulsion formulation for chemoembolization and a preparation method thereof are provided, thereby improving stability of the emulsion formulation, and applying the paclitaxel to artery chemoembolization. CONSTITUTION: The paclitaxel mixed composition comprises 50 to 98.9%(v/v) of oily contrast media containing 0.01 to 1%(w/v) of paclitaxel, and 0.1 to 50%(v/v) of water-soluble contrast media. The water-in-oil type emulsion formulation for chemoembolization comprises 50 to 98.9%(v/v) of oily contrast media, 0.1 to 50%(v/v) of water-soluble contrast media, and 0.01 to 1%(w/v) of paclitaxel, wherein the oily contrast media are iodized oil containing 30 to 50% of iodine content selected from iodized poppy seed oil, ethiodol and iodized soybean oil; the water-soluble contrast media are selected from Metrizamide, Diatrizoate, Ioxaglate, Iopentol, Iopamidol, Iomeprol, Iotrolan, Iohexol, Ioversol, Ioxilan, Iopromide, Iodixanol or Iobitridol.

Abstract translation: 目的：提供紫杉醇混合组合物，其用于化学栓塞的油包水型乳液制剂及其制备方法，从而提高乳液制剂的稳定性，并将紫杉醇应用于动脉化学栓塞。 构成：紫杉醇混合组合物包含含有0.01至1％（w / v）紫杉醇和0.1至50％（v / v）水溶性造影剂的50至98.9％（v / v）油性造影剂。 用于化学栓塞的油包水型乳液制剂包含50至98.9％（v / v）的油性造影剂，0.1至50％（v / v）的水溶性造影剂，和0.01至1％（w / v）的紫杉醇，其中所述油性造影剂是含有选自碘化罂粟籽油，碘化碘和碘化大豆油中的30-50％碘含量的碘化油; 水溶性造影剂选自Metrizamide，Diatrizoate，Ioxaglate，Iopentol，Iopamidol，Iomeprol，Iotrolan，Iohexol，Ioversol，Ioxilan，Iopromide，Iodixanol或Iobitridol。

公开(公告)号：KR1020000002280A

公开(公告)日：2000-01-15

申请号：KR1019980022953

申请日：1998-06-18

Applicant: 한국과학기술연구원

Inventor： 이강봉 ,  박현미 ,  김영만

IPC: B01D53/02 ,  B01D53/04

CPC classification number: B01J20/24 ,  A61L9/013 ,  B01D53/02 ,  B01D2257/708 ,  B01J20/3021

Abstract: PURPOSE: A solvent is provided to efficiently concentrate the volatile organic compound at a moderate cost without using a liquid nitrogen. CONSTITUTION: A producing method of solvent compounded by crab shell powder of 60-80 mesh fineness for the volatile organic compound concentration comprises the steps of: removing all contents of a crab completely; washing; drying at 100-120°C; and milling to be 60-80 mesh fineness.

Abstract translation: 目的：提供溶剂以有效地将挥发性有机化合物以适中的成本浓缩而不使用液氮。 构成：用于挥发性有机化合物浓度的60-80目细度的蟹壳粉末混合的溶剂的制备方法包括以下步骤：完全去除所有的螃蟹内容物; 洗涤; 在100-120℃干燥; 铣削为60-80目的细度。