아임계수를 이용한 병풀로부터의 아시아틱산과아시아티코사이드의 추출 및 분리 방법
    6.
    发明公开
    아임계수를 이용한 병풀로부터의 아시아틱산과아시아티코사이드의 추출 및 분리 방법 有权
    使用亚临床水提取和分离亚洲亚洲亚洲亚砷酸

    公开(公告)号:KR1020090122049A

    公开(公告)日:2009-11-26

    申请号:KR1020080048247

    申请日:2008-05-23

    Abstract: PURPOSE: A method for extracting and isolating a physiological material from Centella asiatica is provided to promote wound healing, cell proliferation, and collagen synthesis. CONSTITUTION: A method for extracting and isolating asiatic acid and asiaticoside comprises: a step of injecting Centella asiatica in a reactor to contact with water; a step of increasing temperature and pressure of water to make to subcritical water; a step of contacting the Centella asiatica and subcritical water to prepare Centella asiatica extract; a step of lowering the temperature and pressure of the subcritical water to collect the Centella asiatica extract; and a step of filtering the Centella asiatica extract to obtain asiatic acid and asiaticoside.

    Abstract translation: 目的:提供一种从积雪草提取和分离生理材料的方法,以促进伤口愈合,细胞增殖和胶原合成。 构成:提取和分离积雪草酸和积雪草苷的方法包括:将积雪草积聚在反应器中与水接触的步骤; 增加水分对亚临界水的温度和压力的步骤; 接触积雪草和亚临界水以制备积雪草提取物的步骤; 降低亚临界水的温度和压力以收集积雪草提取物的步骤; 以及过滤积雪草提取物以获得积雪草酸和积雪草苷的步骤。

    세팔로스포린 유도체의 제조방법
    7.
    发明授权
    세팔로스포린 유도체의 제조방법 失效
    制备CEPHOROSPORIN衍生物的方法

    公开(公告)号:KR1019890000523B1

    公开(公告)日:1989-03-20

    申请号:KR1019860003550

    申请日:1986-05-07

    CPC classification number: C07D501/36 C07D501/32

    Abstract: Cephalosporins (I)[R1=H, CHO; X=(II) or O2CCH3 were prepd.. Thus, 7- amino-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4carboxylic acid and monotrimethylacetamide in ethylacetate was heated for 50min at 50≦̸C, cooled to >=-15≦̸C, and then reacted with a mixt. of D- mandelic acid formate ester and diphenyl-2-pyridone1-phosphate in triethylamine for 150min at 50≦̸C with stirring. The reaction mixt. was extd. with ethylacetate/H2O (1:1) and filtered. The aq. phase extd. with ethylacetate and org. phase pooled, washed with 5% HNO3 and satd. NaCl over 2 times, resptly.. The org. phase was dried on MgSO4, filtered, vacuum-evapd, and crystallized with ethylacetate/n- hexane.

    Abstract translation: 头孢菌素(I)[R1 = H,CHO; 因此,将7-氨基-3-(1-甲基-1H-四唑-5-基硫甲基)-3-头孢烯-4-羧酸和单三乙基乙酰胺在乙酸乙酯中的混合物在50℃加热50分钟; C,冷却至> = -15℃,然后与混合物反应。 的D-扁桃酸甲酸酯和二苯基-2-吡啶酮-1-磷酸酯在三乙胺中在50℃和150℃搅拌150分钟。 反应混合 被释放 用乙酸乙酯/ H 2 O(1:1)洗涤并过滤。 水。。 相变 与乙酸乙酯和组织。 阶段合并,用5%HNO3和satd洗涤。 NaCl超过2次, 相用MgSO 4干燥,过滤,真空蒸发,用乙酸乙酯/正己烷结晶。

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