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公开(公告)号：KR100027921B1
公开(公告)日：1989-06-08
申请号：KR1019860003550
申请日：1986-05-07
Applicant: 한국과학기술연구원
IPC: C07D501/24 , C07D501/26
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公开(公告)号：KR100023857B1
公开(公告)日：1987-07-22
申请号：KR1019840003730
申请日：1984-06-29
Applicant: 한국과학기술연구원
IPC: C07D279/00
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公开(公告)号：KR100022290B1
公开(公告)日：1986-12-10
申请号：KR1019840001588
申请日：1984-03-27
Applicant: 한국과학기술연구원
IPC: C07D401/04
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公开(公告)号：KR100021242B1
公开(公告)日：1986-06-04
申请号：KR1019830005919
申请日：1983-12-14
Applicant: 한국과학기술연구원
IPC: C07D309/38
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公开(公告)号：KR100984531B1
公开(公告)日：2010-10-01
申请号：KR1020080048247
申请日：2008-05-23
Applicant: 한국과학기술연구원
IPC: A61K31/192 , A61K31/704 , A61K36/23
Abstract: 본 발명은 병풀(
Centella asiatica(L) Urb )로부터의 생리활성 물질의 추출 및 분리 방법에 관한 것으로, 보다 자세하게는 인체에 무해하고 환경친화적인 용매인 아임계수를 이용하여 상처치유 촉진, 우수한 세포증식, 콜라겐 합성 등의 효과를 갖는 물질인 아시아틱산과 아시아티코사이드를 입자 상태로 추출하여 분리하는 방법에 관한 것이다.
병풀, 아시아틱산, 아시아티코사이드, 아임계수, 추출, 분리, 여과-
Patent Agency Ranking
公开(公告)号：KR1020090122049A
公开(公告)日：2009-11-26
申请号：KR1020080048247
申请日：2008-05-23
Applicant: 한국과학기술연구원
IPC: A61K31/192 , A61K31/704 , A61K36/23
Abstract: PURPOSE: A method for extracting and isolating a physiological material from Centella asiatica is provided to promote wound healing, cell proliferation, and collagen synthesis. CONSTITUTION: A method for extracting and isolating asiatic acid and asiaticoside comprises: a step of injecting Centella asiatica in a reactor to contact with water; a step of increasing temperature and pressure of water to make to subcritical water; a step of contacting the Centella asiatica and subcritical water to prepare Centella asiatica extract; a step of lowering the temperature and pressure of the subcritical water to collect the Centella asiatica extract; and a step of filtering the Centella asiatica extract to obtain asiatic acid and asiaticoside.
Abstract translation: 目的：提供一种从积雪草提取和分离生理材料的方法，以促进伤口愈合，细胞增殖和胶原合成。 构成：提取和分离积雪草酸和积雪草苷的方法包括：将积雪草积聚在反应器中与水接触的步骤; 增加水分对亚临界水的温度和压力的步骤; 接触积雪草和亚临界水以制备积雪草提取物的步骤; 降低亚临界水的温度和压力以收集积雪草提取物的步骤; 以及过滤积雪草提取物以获得积雪草酸和积雪草苷的步骤。
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公开(公告)号：KR1019890000523B1
公开(公告)日：1989-03-20
申请号：KR1019860003550
申请日：1986-05-07
Applicant: 한국과학기술연구원
IPC: C07D501/24 , C07D501/26
CPC classification number: C07D501/36 , C07D501/32
Abstract: Cephalosporins (I)[R1=H, CHO; X=(II) or O2CCH3 were prepd.. Thus, 7- amino-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4carboxylic acid and monotrimethylacetamide in ethylacetate was heated for 50min at 50≦̸C, cooled to >=-15≦̸C, and then reacted with a mixt. of D- mandelic acid formate ester and diphenyl-2-pyridone1-phosphate in triethylamine for 150min at 50≦̸C with stirring. The reaction mixt. was extd. with ethylacetate/H2O (1:1) and filtered. The aq. phase extd. with ethylacetate and org. phase pooled, washed with 5% HNO3 and satd. NaCl over 2 times, resptly.. The org. phase was dried on MgSO4, filtered, vacuum-evapd, and crystallized with ethylacetate/n- hexane.
Abstract translation: 头孢菌素（I）[R1 = H，CHO; 因此，将7-氨基-3-（1-甲基-1H-四唑-5-基硫甲基）-3-头孢烯-4-羧酸和单三乙基乙酰胺在乙酸乙酯中的混合物在50℃加热50分钟; C，冷却至> = -15℃，然后与混合物反应。 的D-扁桃酸甲酸酯和二苯基-2-吡啶酮-1-磷酸酯在三乙胺中在50℃和150℃搅拌150分钟。 反应混合 被释放 用乙酸乙酯/ H 2 O（1:1）洗涤并过滤。 水。。 相变 与乙酸乙酯和组织。 阶段合并，用5％HNO3和satd洗涤。 NaCl超过2次， 相用MgSO 4干燥，过滤，真空蒸发，用乙酸乙酯/正己烷结晶。
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8.发明授权7-[D(-)-α-(4-히드록시-6-메틸피리딘-3-카르복스아미도)-α-(4-히드록시페닐)아세트아미도]-3-[(1-메틸-1H-테트라졸-5-일)티오메틸]-3-세펨-4-카르복실산의 제조방법 失效-3 - [（1-甲基哌嗪-1-基）甲基] -4- -1H-四唑-5-基）硫代甲基] -3-头孢烯-4-羧酸
公开(公告)号：KR100021993B1
公开(公告)日：1986-10-28
申请号：KR1019840001590
申请日：1984-03-27
Applicant: 한국과학기술연구원
IPC: C07D501/36
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公开(公告)号：KR100021878B1
公开(公告)日：1986-10-15
申请号：KR1019840001589
申请日：1984-03-27
Applicant: 한국과학기술연구원
IPC: C07D213/82
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公开(公告)号：KR100007020B1
公开(公告)日：1979-10-16
申请号：KR1019780001781
申请日：1978-06-12
Applicant: 한국과학기술연구원
IPC: C07D211/70 , A61P29/00
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