公开(公告)号：KR101387400B1

公开(公告)日：2014-04-21

申请号：KR1020120131915

申请日：2012-11-20

Applicant: 한국과학기술연구원

Inventor： 심태보 ,  윤호종 ,  김직녀

IPC: C07D313/00 ,  A61K31/335 ,  A61P35/00

CPC classification number: C07D313/00 ,  C07D317/20 ,  C07D317/22 ,  C07D317/30 ,  C07D317/32 ,  C07D319/08 ,  C07D407/10 ,  C07D493/08

Abstract: The present invention relates to a novel resorcylic acid lactone compound having an a protein kinase inhibitory activity or a pharmaceutically acceptable salt thereof, a manufacturing method of the compound, and a drug composition comprising the compound as an active ingredient for treating and preventing various cancer diseases. The resorcylic acid lactone compound of the present invention is effective as a blood cancer medicine among cancer-induced diseases and particularly shows an excellent effect for a treatment of acute myelogenous leukemia (AML).

Abstract translation: 本发明涉及具有蛋白激酶抑制活性的新型间苯二甲酸内酯化合物或其药学上可接受的盐，该化合物的制造方法和药物组合物，其含有该化合物作为治疗和预防各种癌症疾病的有效成分 。 本发明的间苯二酸内酯化合物作为癌症疾病中的血癌药物是有效的，特别是对治疗急性骨髓性白血病（AML）具有优异的效果。