公开(公告)号：KR101341935B1

公开(公告)日：2013-12-19

申请号：KR1020110143688

申请日：2011-12-27

Applicant: 한국과학기술연구원

Inventor： 정병화 ,  이수현 ,  박성하

IPC: G01N33/68 ,  G01N33/53

Abstract: 본발명은아미노산대사경로의생체대사체및 지질대사경로의생체대사체중 하나이상의생체대사체를포함하는노화로인한면역력저하진단용마커를개시한다.

公开(公告)号：KR1020130075352A

公开(公告)日：2013-07-05

申请号：KR1020110143688

申请日：2011-12-27

Applicant: 한국과학기술연구원

Inventor： 정병화 ,  이수현 ,  박성하

IPC: G01N33/68 ,  G01N33/53

Abstract: PURPOSE: A biomarker is provided to be related to immunity reduction due to aging, and to be used as a marker for diagnosis of immunity reduction. CONSTITUTION: A biomarker for diagnosis of immunity reduction due to aging contains one or more metabolites among a metabolite of an amino acid metabolism pathway and a metabolite of a lipid metabolism pathway. The metabolite of an amino acid metabolism pathway contains one or more metabolites selected from the group consisting of cysteic acid, homocysteine, taurine, L-cystathionine, S-adenosyl homocysteine, dimethyl-L-arginine, N10-formyl-tetrahydrofolate, 5,10-methenyl tetrahydrofolate, methionine sulfoxide, cystathionine sulfoxide, S-nitroso glutathionine, and 5-hydroxy-N-formylkynurenine. The biomarker is used for diagnosing immunity reduction due to aging from urine or blood.

Abstract translation: 目的：提供一种生物标志物与衰老引起的免疫力降低有关，并用作诊断免疫力降低的标记物。 构成：用于诊断由于衰老引起的免疫力降低的生物标志物在氨基酸代谢途径的代谢物和脂质代谢途径的代谢物中含有一种或多种代谢物。 氨基酸代谢途径的代谢物含有选自下列的一种或多种代谢物：半胱氨酸，高半胱氨酸，牛磺酸，L-胱硫醚，S-腺苷高半胱氨酸，二甲基-L-精氨酸，N10-甲酰四氢叶酸，5,10 - 甲基四氢叶酸，甲硫氨酸亚砜，胱硫醚亚砜，S-亚硝基谷胱甘肽和5-羟基-N-甲酰基鸟嘌呤。 生物标志物用于诊断由于尿液或血液衰老引起的免疫力降低。