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    ＮＣＸ2 단백질의 활성을 억제함으로써 학습능력 및기억력을 증진시키는 방법
    1.
    发明公开
    ＮＣＸ2 단백질의 활성을 억제함으로써 학습능력 및기억력을 증진시키는 방법 失效
    通过抑制NCX2蛋白活性来增强学习和记忆的方法

    公开(公告)号：KR1020040066248A

    公开(公告)日：2004-07-27

    申请号：KR1020030003247

    申请日：2003-01-17

    Applicant: 한국과학기술연구원

    Inventor： 신희섭 ,  전대종 ,  임혜원 ,  양유미

    IPC: A61K38/00

    CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/00 ,  C12N15/8509 ,  C12N2800/30 ,  G01N33/6872

    Abstract: PURPOSE: A method for enhancing learning and memory by suppressing the activity of NCX2(natrium calcium exchanger 2) protein is provided, thereby slowly removing Ca2+, secreting numerous neurotransmitters, inducing and maintaining LTP(long-term potentiation) and enhancing the activity of synapse. CONSTITUTION: The method for enhancing learning and memory by suppressing the activity of NCX2 protein comprises suppressing the activity of NCX2 protein, wherein the suppression of the NCX2 protein activity is achieved by inhibiting the expression of NCX2 gene; the inhibition of the NCX2 gene expression is achieved by gene targeting of NCX2 gene using antisense gene. A method for screening a material regulating learning and memory comprises the steps of: (1) transforming a host cell with a vector containing NCX2 structure gene and reporter gene to prepare a transformant; (2) co-culturing the transformant with a sample to be screened; and (3) measuring the expression of the reporter gene.

    Abstract translation: 目的：提供通过抑制NCX2（钠钙交换2）蛋白的活性来增强学习和记忆的方法，从而缓慢去除Ca2 +，分泌大量神经递质，诱导和维持LTP（长期增强）并增强突触的活性 。 构成：通过抑制NCX2蛋白的活性来增强学习和记忆的方法包括抑制NCX2蛋白的活性，其中通过抑制NCX2基因的表达来实现NCX2蛋白活性的抑制; 通过使用反义基因的NCX2基因的基因靶向来实现NCX2基因表达的抑制。 用于筛选调节学习和记忆的材料的方法包括以下步骤：（1）用含有NCX2结构基因和报道基因的载体转化宿主细胞以制备转化体; （2）将转化体与待筛选的样品共培养; 和（3）测量报道基因的表达。

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