公开(公告)号：KR1020100035063A

公开(公告)日：2010-04-02

申请号：KR1020080094366

申请日：2008-09-25

Applicant: 한국과학기술연구원

Inventor： 유경호 ,  김동진 ,  김영수 ,  이여란

IPC: C07D513/04

CPC classification number: C07D513/04 ,  C07D498/04

Abstract: PURPOSE: A thia(oxa)zolopyridine compound and a method for preparing the same are provided to suppress beta-amyloid fibril formation and use as an agent for preventing and treating neurodegenerative diseases. CONSTITUTION: A thia(oxa)zolopyridine compound is denoted by chemical formula 1. The compound of chemical formula 1 is prepared by cyclizing a compound of chemical formula 2. An agent for suppressing formation of beta-amyloid fibril contains the thia(oxa)zolopyridine compound of chemical formula 1 or pharmaceutically acceptable salt as an active ingredient. A pharmaceutical composition for treating neurodegenerative diseases contains the thia(oxa)zolopyridine compound or pharmaceutically acceptable salt as an active ingredient.

Abstract translation: 目的：提供硫代（oxa）唑吡啶化合物及其制备方法以抑制β-淀粉样蛋白原纤维形成和用作预防和治疗神经变性疾病的药剂。 构成：化学式1表示噻吩（oxa）唑吡啶化合物。化学式1的化合物是通过使化学式2的化合物环化而制备的。用于抑制β-淀粉样蛋白原纤维形成的试剂含有硫代（oxa）唑吡啶 化学式1的化合物或其药学上可接受的盐作为活性成分。 用于治疗神经变性疾病的药物组合物含有硫代（oxa）唑吡啶化合物或其药学上可接受的盐作为活性成分。

公开(公告)号：KR101074025B1

公开(公告)日：2011-10-17

申请号：KR1020080094366

申请日：2008-09-25

Applicant: 한국과학기술연구원

Inventor： 유경호 ,  김동진 ,  김영수 ,  이여란

IPC: C07D513/04

CPC classification number: C07D513/04 ,  C07D498/04

Abstract: 식중에서, A, R, R및 R은명세서중에정의한바와같다.