公开(公告)号：KR1020120088398A

公开(公告)日：2012-08-08

申请号：KR1020110009730

申请日：2011-01-31

Applicant: 한국과학기술연구원

Inventor： 배애님 ,  조용서 ,  추현아 ,  최경일 ,  김동진 ,  서선희 ,  임혜원 ,  최기현 ,  송치만 ,  김윤정 ,  임건승

IPC: C07D413/06 ,  C07D413/12 ,  A61K31/496 ,  A61P9/00

Abstract: PURPOSE: A pharmaceutical composition containing pentagonal heteroaromatic compound, a pharmaceutically acceptable salt thereof having a pharmaceutical activity to T-type calcium channel is provided to treat heart disease, brain diseases, stroma, chronic pain, neuropathic pain, and cancer. CONSTITUTION: A pentagonal heteroaromtaic compound with T-type calcium channel is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating stroma, hypertension, angina, chronic pain, neuropathic pain, and cancer contains the compound as an active ingredient. A method for preparing the compound comprises a step of binding carbochloride compound of chemical formula 3a and heterocyclic amine compounds of chemical formula 2a under the presence of an alkyl amine base.

Abstract translation: 目的：提供含有对T型钙通道具有药学活性的五价杂芳族化合物及其药学上可接受的盐的药物组合物，用于治疗心脏病，脑疾病，基质，慢性疼痛，神经性疼痛和癌症。 构成：用化学式1表示具有T型钙通道的五价杂合化合物。用于预防和治疗基质，高血压，心绞痛，慢性疼痛，神经性疼痛和癌症的药物组合物含有该化合物作为活性成分。 制备该化合物的方法包括在烷基胺基的存在下结合化学式3a的氯化碳化合物和化学式2a的杂环胺化合物的步骤。