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公开(公告)号：KR1019950025440A
公开(公告)日：1995-09-15
申请号：KR1019940002419
申请日：1994-02-08
Applicant: 한국과학기술연구원
IPC: G01P5/00
Abstract: 본 발명은 레이저를 이용한 유체의 속도 측정 특히 LDV 방식과 시차 방식을 결합 이용한 유체 속도측정 장치 및 방법에 관한 것이다. 본 발명에 따른 유체 속도 측정 장치는 레이저 광원(1), 분극 성분분리 수단(3)과 평행 빔 분할기(4)로 이루어어진 빔 분할 수단(2), 분극 성분을 가진 빔끼리 간섭을 형성하도록 빔들을 집속시키기 위한 집속 렌즈(5), 유체 입자에 의한 산란광을 집속시키기 위한 집속렌즈(6), 집속된 산란광을 검출하기 위한 광 검출기(7) 및 이 검출된 광 신호를 분석하기 위한 광 신호분석기(8)로 구성된다. 본 발명은 LDV 방식과 시차 방식을 결합 이용하여 두 가지 방식의 장점만을 모두 갖추고 있으며, 상기 두 가지 방식의 어느 것보다 우수한 유체 속도 측정 방법 및 그 장치를 개시하고 있다.
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2.发明公开신규 피리도[2,3-ｄ]피리미딘 카르보알데히드 옥심계ＰＤＥ Ⅳ 효소 저해 화합물 및 이의 제조방법 失效PYRIDO [2,3-D]吡啶二羰基氧化物衍生物作为PDE IV抑制剂及其制备方法有用
公开(公告)号：KR1020030076072A
公开(公告)日：2003-09-26
申请号：KR1020020015728
申请日：2002-03-22
IPC: C07D471/04
Abstract: PURPOSE: Pyrido£2,3-d|pyridine carboaldehyde oxime derivatives useful as PDE IV inhibitor and a preparation method thereof are provided, which compounds are useful for treatment of respiration diseases, and diseases associated with TNF(tumor necrosis factor) formation. CONSTITUTION: Pyrido£2,3-d|pyridine carboaldehyde oxime derivatives represented by formula (I) or pharmaceutically acceptable salts are provided, wherein R1 is C1-3 lower alkyl, C3-7 cycloalkyl, cycloalkyloxy, cycloalkylamino, cycloalkyl lower alkyl, C1-3 lower alkoxy, formyl, hydroxy lower alkyl or carboxyalkyl, or X-substituted phenyl, in which X is methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, propoxy, isopropoxy, cyano, carboxylic acid, carboxymethyl ester, carboxyethyl ester, nitro, fluoro or trifluoromethyl; R2 is hydrogen or methyl; and R3 is hydrogen, methyl, C3-7 lower alkyloxy, allyl, phenyl, benzyl, X-substituted phenyl, methyloxyphenyl or methyloxy Y-substituted phenyl in which X is cyano, halogen, carboxyalkyl, nitro, methyl, trihalogenated methyl or alkyloxy, and Y is methoxy. A method for preparing pyrido£2,3-d|pyridine carboaldehyde oxime derivatives of formula (I) comprises preparing a compound of formula (III) from a compound of formula (II) in the presence of palladium catalyst and base; reacting the compound of formula (III) with hydroxylamine, alkyloxyamine or hydrochloric acid salts thereof.
Abstract translation: 目的：提供用作PDE IV抑制剂的吡啶2,3-d-吡啶甲醛肟衍生物及其制备方法，该化合物可用于治疗呼吸疾病和与TNF（肿瘤坏死因子）形成相关的疾病。 构成：提供由式（I）表示的吡啶2,3-d-吡啶甲醛肟衍生物或其药学上可接受的盐，其中R 1为C 1-3低级烷基，C 3-7环烷基，环烷氧基，环烷基氨基，环烷基低级烷基，C 1 -3低级烷氧基，甲酰基，羟基低级烷基或羧基烷基或X取代的苯基，其中X是甲基，乙基，丙基，异丙基，甲氧基，乙氧基，丙氧基，异丙氧基，氰基，羧酸，羧甲基酯，羧乙基酯， 硝基，氟或三氟甲基; R2是氢或甲基; R 3为氢，甲基，C 3-7低级烷氧基，烯丙基，苯基，苄基，X取代苯基，甲氧基苯基或甲氧基Y取代苯基，其中X为氰基，卤素，羧基烷基，硝基，甲基，三卤代甲基或烷氧基， Y为甲氧基。 制备式（I）的吡啶并[2,3-d]吡啶甲醛肟衍生物的方法包括在钯催化剂和碱的存在下由式（II）化合物制备式（III）化合物; 使式（III）的化合物与羟胺，烷氧基胺或其盐酸盐反应。
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Patent Agency Ranking3.发明公开아미노메틸계 피리도[2,3-ｄ]피리미딘-2,4-디온 ＰＤＥ Ⅳ효소 억제 화합물 및 이의 제조방법 失效有益于PDE IV抑制剂的吡啶并[2,3-D]哒嗪-2,4-二酮的氨基甲酸衍生物及其制备方法
公开(公告)号：KR1020030076073A
公开(公告)日：2003-09-26
申请号：KR1020020015729
申请日：2002-03-22
IPC: C07D471/04
Abstract: PURPOSE: Pyrido£2,3-d|pyridine-2,4-dione aminomethyl derivatives useful as PDE IV inhibitor and a preparation method thereof are provided, which compounds are useful for treatment of respiration diseases, and diseases associated with TNF(tumor necrosis factor) formation. CONSTITUTION: Pyrido£2,3-d|pyridine-2,4-dione aminomethyl derivatives represented by formula (I) or pharmaceutically acceptable salts are provided, wherein R1 is C1-3 lower alkyl, C3-7 cycloalkyl, cycloalkyloxy, cycloalkyl lower alkyl, C1-3 lower alkoxy, formyl, hydroxy lower alkyl or carboxyalkyl, phenyl or X-substituted phenyl, in which X is methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, propoxy, isopropoxy, cyano, carboxylic acid, carboxymethyl ester, carboxyethyl ester, nitro, fluoro or trifluoromethyl; R2 is C1-3 lower alkyl, C3-7 cycloalkyl, hydroxy, C1-6 lower alkylhydroxy, benzyl, X-substituted phenyl, C1-3 lower alkylphenyl, C1-3 lower alkyl substituted pyridine, C1-3 lower alkyl imidazol, morpholine, C1-3 lower alkyl morpholine, C1-3 lower alkyl piperazine, 4-substituted C1-3 lower alkyl piperazine in which the substituent is hydroxyethyl or methyl, alkylpyrrol or N-substituted alkylpyrrol, in which X is cyano, halogen, carboxyalkyl, nitro, methyl, trihalogenated methyl or alkyloxy; and R3 is hydrogen or methyl, and R2 and R3 are the same or different together. A method for preparing pyrido£2,3-d|pyridine-2,4-dione aminomethyl derivatives of formula (I) comprises preparing a compound of formula (III) from a compound of formula (II), and reducing the compound of formula (III).
Abstract translation: 目的：提供用作PDE IV抑制剂的吡啶2,3-d-吡啶-2,4-二酮氨基甲基衍生物及其制备方法，该化合物可用于治疗呼吸疾病和与TNF相关的疾病（肿瘤坏死 因子）形成。 构成：提供由式（I）表示的吡啶并[2,3-d]吡啶-2,4-二酮氨基甲基衍生物或其药学上可接受的盐，其中R 1为C 1-3低级烷基，C 3-7环烷基，环烷氧基，环烷基低级 烷基，C 1-3低级烷氧基，甲酰基，羟基低级烷基或羧基烷基，苯基或X取代的苯基，其中X是甲基，乙基，丙基，异丙基，甲氧基，乙氧基，丙氧基，异丙氧基，氰基，羧酸， ，羧乙基酯，硝基，氟或三氟甲基; R2是C1-3低级烷基，C3-7环烷基，羟基，C1-6低级烷基羟基，苄基，X取代的苯基，C1-3低级烷基苯基，C1-3低级烷基取代的吡啶，C1-3低级烷基咪唑，吗啉 ，C 1-3低级烷基吗啉，C 1-3低级烷基哌嗪，其中取代基为羟乙基或甲基的4-取代的C 1-3低级烷基哌嗪，其中X为氰基，卤素，羧基烷基， 硝基，甲基，三卤代甲基或烷氧基; 并且R 3是氢或甲基，并且R 2和R 3在一起是相同或不同的。 制备式（I）的吡啶并[2,3-d]吡啶-2,4-二酮氨基甲基衍生物的方法包括由式（II）化合物制备式（III）的化合物，还原式 （III）。
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5.发明授权아미노메틸계 피리도[2,3-ｄ]피리미딘-2,4-디온 ＰＤＥ Ⅳ효소 억제 화합물 및 이의 제조방법 失效新颖的吡啶[2,3-α]吡嗪-2,4-二酮的氨基甲酸酯衍生物有效为A ？ 抑制剂及其制备方法
公开(公告)号：KR100522533B1
公开(公告)日：2005-10-20
申请号：KR1020020015729
申请日：2002-03-22
IPC: C07D471/04
Abstract: 본 발명에 따르면 다음의 일반식 (I)로 표시되는 신규한 아미노메틸계 피리도[2,3-d]피리미딘 2,4-디온 화합물, 이의 제조방법 및 이의 선택적 포스포디에스테라아제 IV (PDE IV)효소 활성 억제 효과에 의한 약리학적 적용에 관한 것이다.
(I)-
6.发明授权
公开(公告)号：KR100490970B1
公开(公告)日：2005-05-24
申请号：KR1020020015728
申请日：2002-03-22
IPC: C07D471/04
Abstract: 본 발명은 다음의 일반식 (I)로 표시되는 신규한 피리도[2,3-d]피리미딘 카르보알데히드 옥심계 화합물 또는 약학적으로 허용되는 이들의 염, 이들의 제조방법 및 이들의 선택적 포스포디에스테라아제 IV 효소 활성 억제 효과에 의한 약리학적 적용에 관한 것이다.
(I)-
公开(公告)号：KR1019960008447B1
公开(公告)日：1996-06-26
申请号：KR1019940002419
申请日：1994-02-08
Applicant: 한국과학기술연구원
IPC: G01P5/00
Abstract: The apparatus and method measures definitely the fluid speed with a wide range of cm/sec to km/sec by compensating the uncertainty of either the LVD or time of flight measurement method. The apparatus comprises: a laser beam source(1); a beam division means(2) dividing polar components of the laser beam, emitted from the beam source(1), into 4 parallel beams; one focus lens(5) focusing the 4 beams in order to make the same polar beams interfere with each other; the other focus lens(6) focusing scattered beams resulted from the phenomenon of making particles in the fluid pass through the interference pattern formed from the focused beams; an optical detector(7) detecting the scattered beams focused by the lens(6).
Abstract translation: 该装置和方法通过补偿LVD或飞行时间测量方法的不确定性来确定具有宽范围cm / sec至km / sec的流体速度。 该装置包括：激光束源（1）; 光束分割装置（2）将从光束源（1）发射的激光束的极化分量分成4个平行光束; 一个聚焦透镜（5）聚焦4个光束，以使相同的极化光束相互干扰; 聚焦散射光束的另一个聚焦透镜（6）由于使流体中的粒子流过由聚焦光束形成的干涉图案而产生的散射光; 检测由所述透镜（6）聚焦的散射光束的光学检测器（7）。
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