公开(公告)号：KR100737167B1

公开(公告)日：2007-07-10

申请号：KR1020060054236

申请日：2006-06-16

Applicant: 한국과학기술연구원

Inventor： 김수현 ,  정영미 ,  정기철 ,  김상헌

IPC: A61F2/28 ,  A61F2/00

Abstract: Provided is a porous osteochondral composite scaffold with layer structure which has features of bioactivation and mechanical strength suitable to regenerate cartilage and bone simultaneously and method for manufacturing the same. The porous osteochondral composite scaffold comprises: a porous bone regeneration layer which includes biocompatable high molecule and bioactivation ceramic; a porous cartilage regeneration layer which includes biocompatable elastic high molocule. The method for manufacturing a porous osteochondral composite scaffold comprises the steps of: mixing biocompatable high molecule, bioactivation ceramic and lacuna-forming material; press-forming the mixed material from the first step in a mold; bonding the obtained material from the second step by heating to form a porous bone regeneration layer; forming composite material by press-forming gelled mixed material for forming cartilage which dissolves in solution with biocompatable high molecule and lacuna-forming material on one surface of the regenerated layer from the third step; removing solution and lacuna-forming material in the composite material from the fourth step.

Abstract translation: 本发明提供一种具有适于同时再生软骨和骨的具有生物活化和机械强度特征的层状结构的多孔骨软骨复合支架及其制造方法。 多孔骨软骨复合支架包括：多孔骨再生层，其包含生物相容性高分子和生物活化陶瓷; 包含生物相容性弹性高分子量多孔体的多孔软骨再生层。 制备多孔骨软骨复合支架的方法包括以下步骤：混合生物相容性高分子，生物活化陶瓷和腔隙形成材料; 在模具中将来自第一步骤的混合材料压制成形; 通过加热将来自第二步骤的所得材料结合以形成多孔骨再生层; 通过在第三步骤的再生层的一个表面上通过压制成型用于形成软骨的凝胶化混合材料形成复合材料，所述软骨溶解于具有生物相容性高分子和空腔形成材料的溶液中; 从第四步移除复合材料中的溶液和空穴形成材料。