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    대두유 탈취 증류분으로부터 토코페롤을 정제하는 방법
    2.
    发明授权
    대두유 탈취 증류분으로부터 토코페롤을 정제하는 방법 失效
    大豆油清除方法

    公开(公告)号：KR1019930005415B1

    公开(公告)日：1993-06-21

    申请号：KR1019910001231

    申请日：1991-01-25

    Applicant: 한국과학기술연구원

    Inventor： 박영훈 ,  정봉현 ,  정수민 ,  손정덕 ,  신현호

    IPC: C07D311/72

    Abstract: The tocopherol is purifyed by (a) adding mixed solvent of n- hexane and 50 % (v/v) methanol into the soybean oil distillate, (b) removing the sterol of the mixt. by filtering, cooling the filtered soln., and re-filtering, (c) methyl esterifying the mixt. from which sterol is removed, (d) recirculating esterified product at 100-130 deg.C and 10-3-10-4 torr in the molecular distillator to remove fatty acid methyl ester, (e) concentrating the obtd. soln. contg. 50-55 % tocopherol and dissolving in the lower alcohol (I), (f) adsorbing it into alkaline anion exchange resin, and purifying with the (I) contg. 5-10 % acetic acid, and (g) dissolving the purifyed tocopherol in the (I) and passing through cation exchange resin to obtain the final product.

    Abstract translation: 生育酚通过（a）将正己烷和50％（v / v）甲醇的混合溶剂加入大豆油馏出物中，（b）除去混合物的固醇来纯化。 通过过滤，冷却过滤的溶胶，并重新过滤，（c）甲基酯化混合物。 （d）在分子蒸馏器中在100-130℃和10-3-10-4乇下再循环酯化产物以除去脂肪酸甲酯，（e）浓缩该物质。 SOLN。 contg。 50-55％生育酚溶于低级醇（I）中，（f）将其吸附到碱性阴离子交换树脂中，用（I） 5-10％乙酸，和（g）将纯化的生育酚溶解在（I）中并通过阳离子交换树脂以获得最终产物。

    생물전환에 의한 하이드로코티손으로부터 프레드니솔론의 제조방법
    4.
    发明授权
    생물전환에 의한 하이드로코티손으로부터 프레드니솔론의 제조방법 失效
    制备预溶剂的方法

    公开(公告)号：KR1019910007857B1

    公开(公告)日：1991-10-02

    申请号：KR1019890000264

    申请日：1989-01-12

    Applicant: 한국과학기술연구원

    Inventor： 박영훈 ,  정봉현 ,  정수민 ,  손정덕

    IPC: C12P33/00

    Abstract: A process for preparing prednisolone from hydrocortisone comprises: (a) pre-culturing arthrobactor simplex at 30 deg.C, pH 7.3 and 150-180rpm in the medium to obtain the starter; (b) innoculating the starter to the culture medium contg. 0-0.2gr. glucose, 0.1-1.0gr. casamino acid, 0.05-0.5gr. KH2PO4, 0.05-0.5gr. K2HPO4, 0.001-0.01gr. Mgcl2, 0.05gr. tween 80 and 100ml D.W., and culturing at 30-37 deg.C, pH 6-9 and 150-180rpm for 4hrs.; (c) adding hydrocortisone powder into the culture broth and culturing at the same condition for 28hrs to obtain the final product. The prednisolone is useful as an antiphlogistic.

    Abstract translation: 从氢化可的松制备泼尼松龙的方法包括：（a）在30℃，pH 7.3和150-180rpm下在培养基中预培养单克隆培养基以获得起子; （b）将起子接种到培养基中。 0-0.2gr。 葡萄糖，0.1-1.0gr。 酪蛋白氨基酸，0.05-0.5gr。 KH2PO4，0.05-0.5gr。 K2HPO4，0.001-0.01gr。 Mgcl2，0.05gr。 吐温80和100ml D.W.，并在30-37℃，pH 6-9和150-180rpm下培养4小时。 （c）将氢化可的松粉末加入到培养液中并在相同条件下培养28小时以获得最终产物。 泼尼松龙是有用的消炎药。

    대두유 탈취 증류분으로부터 스테롤 및 토코페롤을 분리, 농축하는 방법
    6.
    发明授权
    대두유 탈취 증류분으로부터 스테롤 및 토코페롤을 분리, 농축하는 방법 失效
    从大豆油脱臭馏出物中分离和浓缩甾醇和生育酚的方法

    公开(公告)号：KR1019920005695B1

    公开(公告)日：1992-07-13

    申请号：KR1019900012985

    申请日：1990-08-22

    Applicant: 한국과학기술연구원

    Inventor： 박영훈 ,  정봉헌 ,  정수민 ,  손정덕 ,  신현호

    IPC: C11B7/00

    Abstract: A process for separating and concentrating sterol and tocopherol from deodorized distillate of soybean oil comprises (A) adding mixed solvent of n-hexane and 50 % (V/V) methanol to soybean oil distillate, (B) cooling the mixture to 5 deg.C -10 deg.C to separate sterol first, (C) methyl esterifying the mixture from which sterol is removed, (D) recirculating esterified product in a molecular distiller at 100-130 deg.C and 10-2 - 10-4 torr to remove fatty acid methyl ester, and (D) recirculating again it at 170-200 deg.C and 10-2 - 10-4 torr to separate and concentrate tocopherol. The mixing ratio of n-hexane to methanol is 10:1, and addition amount of mixed solvent is 2 or 3 times the amount of soybean oil distillate.

    Abstract translation: 从大豆油的除臭馏分中分离和浓缩固醇和生育酚的方法包括（A）向大豆油馏出物中加入正己烷和50％（V / V）甲醇的混合溶剂，（B）将混合物冷却至5℃。 （C）甲基酯化除去固醇的混合物，（D）在100-130℃和10-2-10-4托的分子蒸馏器中再循环酯化产物 去除脂肪酸甲酯，和（D）再次在170-200℃和10-2-10-4托再循环以分离和浓缩生育酚。 正己烷与甲醇的混合比为10:1，混合溶剂的添加量为豆油馏出物的2〜3倍。

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