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    감귤류과피추출액을포함하는아실코에이:콜레스테롤-오르토-아실트랜스퍼레이즈저해제조성물
    1.
    发明授权
    감귤류과피추출액을포함하는아실코에이:콜레스테롤-오르토-아실트랜스퍼레이즈저해제조성물 失效
    ACYL COA：包含CITRUS PEEL提取物的胆固醇-O-亚氨基转移酶抑制剂组合物

    公开(公告)号：KR100258584B1

    公开(公告)日：2000-07-01

    申请号：KR1019970055580

    申请日：1997-10-28

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  권병목 ,  김영국 ,  배기환 ,  최명숙 ,  권용국 ,  안정아 ,  손광희 ,  최도일 ,  김성욱 ,  박용복 ,  황인규 ,  문석식 ,  이은숙

    IPC: A61K36/752 ,  A61P9/00

    Abstract: PURPOSE: A composition containing orange peel extract for inhibition of acyl CoA:cholesterol-O-acyltransferase(ACAT) is provided, which is useful for preventing and treating various cardiovascular diseases by decreasing blood low density lipoprotein(LDL) cholesterol. CONSTITUTION: A process fro the preparation of composition containing orange peel extract for inhibition of acyl CoA:cholesterol-O-acyltransferase(ACAT) comprises the steps of: washing the peel of tangerine originated in Korea, and drying at normal temperature to get Aurantii Nobilis Pericarpium; adding 95% ethanol, keeping at normal temperature for 24hours, and filtering to get extract and solid residue; extracting the solid residue twice more by the same process, and gathering extracts altogether; and concentrating the extract using a rotary vacuum evaporator under decompression to get concentrated extract containing bio-flavonoids.

    Abstract translation: 目的：提供含有抑制酰基CoA：胆固醇-O-酰基转移酶（ACAT）的橙皮提取物的组合物，其可用于通过降低血液低密度脂蛋白（LDL）胆固醇来预防和治疗各种心血管疾病。 构成：含有橙皮提取物抑制酰基CoA：胆固醇-O-酰基转移酶（ACAT）的组合物的制备方法包括以下步骤：洗涤起始于韩国的橘皮，并在常温下干燥以得到Aurantii Nobilis Pericarpium; 加入95％乙醇，在常温保持24小时，过滤得到提取物和固体残渣; 通过相同的方法提取固体残渣两次，并收集提取物; 并在减压下使用旋转式真空蒸发器浓缩提取物，得到含有生物黄酮的浓缩提取物。

    신규한 페니실리움 그리세오플범 생산균주와 콜레스테롤 대사억제제의 생산
    10.
    发明授权
    신규한 페니실리움 그리세오플범 생산균주와 콜레스테롤 대사억제제의 생산 失效
    空值

    公开(公告)号：KR100264392B1

    公开(公告)日：2000-08-16

    申请号：KR1019980003012

    申请日：1998-02-04

    Applicant: 한국과학기술연구원

    Inventor： 김영국 ,  김미경 ,  권병목 ,  정태숙 ,  김성욱 ,  최도일 ,  황인규 ,  손광희 ,  복성해

    IPC: C12N1/20

    Abstract: PURPOSE: A microorganism, Penicillium griseofulvum, producing pyripyropene A and a method for producing cholesterol metabolism inhibitor are provided, wherein pyripyropene A inhibits the activity of cholesterol acyltransferase(ACAT) which adsorbs cholesterol into blood, and is thus used in decreasing the blood cholesterol concentration. CONSTITUTION: Penicillium griseofulvum F1959 separated from soil by Samson method produces pyripyropene A which inhibits the activity of cholesterol acyltransferase(ACAT) and its inhibition concentration IC50 is about 35 ng/ml which is calculated by the equation. The ACAT inhibitor pyripyropene A is produced by the steps of: incubating Penicillium griseofulvum F1959 in a spawn medium containing 0.5% of glucose, 0.2% of yeast extract, 0.5% of polypeptone, 0.1% of potassium phosphate and 0.05% of magnesium sulfate at 29 deg. C for 18 hours; and incubating the microorganism in a growth medium containing 2% of starch, 0.4% of soytone, 0.3% of pama media, 0.1% of potassium phosphate, 0.05% of magnesium sulfate, 0.3% of calcium carbonate and 0.2% of sodium chloride at 29 deg. C for 120 hours.

    Abstract translation: 目的：提供微生物青霉菌青霉菌，产生吡柔比星A和生产胆固醇代谢抑制剂的方法，其中吡哆灵A抑制胆固醇酰基转移酶（ACAT）的活性，胆固醇酰基转移酶（ACAT）将胆固醇吸附到血液中，因此用于降低血液胆固醇浓度 。 构成：通过Samson方法从土壤中分离的灰黄霉菌F1959产生抑制胆固醇酰基转移酶（ACAT）活性的白藜芦醇A，其抑制浓度IC50为约35ng / ml，其通过该方程式计算。 通过以下步骤制备ACAT抑制剂pyripyropene A：在含有0.5％葡萄糖，0.2％酵母提取物，0.5％多聚蛋白胨，0.1％磷酸钾和0.05％硫酸镁的产卵培养基中将灰黄青霉F1959温育于29℃ 度。 C 18小时; 并在29℃下将微生物培养在含有2％淀粉，0.4％大豆油，0.3％帕马培养基，0.1％磷酸钾，0.05％硫酸镁，0.3％碳酸钙和0.2％氯化钠的生长培养基中 度。 C 120小时。

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