公开(公告)号：KR101173678B1

公开(公告)日：2012-08-13

申请号：KR1020100102522

申请日：2010-10-20

Applicant: 한국과학기술연구원

Inventor： 오창현 ,  정명호 ,  엘가말모하메드 ,  유경호 ,  심태보 ,  최원경 ,  조정혁

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: 본 발명은 흑색종에 대한 항증식 활성이 뛰어난 피롤로[3,2-c]피리딘 유도체 또는 이의 약제학적으로 허용가능한 염, 이의 제조 방법 및 이를 포함하는 약제학적 조성물에 관한 것이다.

公开(公告)号：KR1020120040980A

公开(公告)日：2012-04-30

申请号：KR1020100102522

申请日：2010-10-20

Applicant: 한국과학기술연구원

Inventor： 오창현 ,  정명호 ,  엘가말모하메드 ,  유경호 ,  심태보 ,  최원경 ,  조정혁

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: PURPOSE: A pyrrolo[3,2-c]pyridine derivative and a pharmaceutical composition containing the same are provided to ensure anti-proliferatioin activity of melanoma and to prevent or treat melanoma. CONSTITUTION: A pyrrolo[3,2-c]pyridine derivative is denoted by chemical formula I. A method for preparing the pyrrolo[3,2-c]pyridine derivative of chemical formula I' or pharmaceutically acceptable salt thereof comprises: a step of reacting 4-chloro-1-pyrrolo[2,3-b]pyridine of chemical formula II with nitroaniline to prepare a compound of chemical formula III; a step of reacting a compound of chemical formula III with benzoyl chloride to prepare a compound of chemical formula IV; a step of reducing the compound of chemical formula IV to prepare a compound of chemical formula V; and a step of reacting the compound of chemical formula V with a compound of chemical formula VI or formula VII.

Abstract translation: 目的：提供吡咯并[3,2-c]吡啶衍生物和含有它们的药物组合物，以确保黑色素瘤的抗增殖活性并预防或治疗黑素瘤。 构成：化学式I表示吡咯并[3,2-c]吡啶衍生物。制备化学式I'吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐的方法包括： 使化学式II的4-氯-1-吡咯并[2,3-b]吡啶与硝基苯胺反应制备化学式Ⅲ化合物; 使化学式III的化合物与苯甲酰氯反应以制备化学式IV的化合物的步骤; 降低化学式IV化合物以制备化学式V的化合物的步骤; 以及使化学式V的化合物与化学式VI或式VII的化合物反应的步骤。