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公开(公告)号：KR100362941B1
公开(公告)日：2002-11-30
申请号：KR1019990017558
申请日：1999-05-17
Applicant: 한국과학기술연구원
IPC: A61K31/335
Abstract: 본발명은유효량의헤마테인을함유하는고지혈증및 동맥경화증예방및 치료용조성물에관한것으로, 본발명의조성물은의약용및 식품용조성물을포함한다. 헤마테인은 LDL-항산화제활성을나타내며, 혈중콜레스테롤을현저하게감소시키고, 간마이크로좀 ACAT 활성을강력하게저해하므로, 헤마테인을함유하는본 발명의조성물은고지혈증및 동맥경화증의치료및 예방을위해유용하게사용될수 있다.
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公开(公告)号：KR1020020060115A
公开(公告)日：2002-07-16
申请号：KR1020020027396
申请日：2002-05-17
Applicant: 한국과학기술연구원
IPC: A61K31/335
Abstract: PURPOSE: A pharmaceutical composition containing hematein which is obtainable by extraction of Heartwood of Caesalpinia sappan or commercially as an active ingredient is provided. Because the hematein exhibits LDL-antioxidant activity, remarkably reduces cholesterol in blood and strongly inhibits liver microsome ACAT activity, the composition can be effectively used in prevention and therapeutic treatment of atherosclerosis and hyperlipidemia. CONSTITUTION: The composition for preventing and treating atherosclerosis and hyperlipidemia in mammals contains an effective amount of hematein and a pharmaceutically acceptable carrier as an active component. The hematein inhibits the activity of acyl-CoA : cholesterol acyltransferase or acts as LDL-antioxidant to give an effect on preventing and treating hyperlipidemia.
Abstract translation: 目的：提供含有作为活性成分的可以通过提取凯萨金（Caesalpinia sappan）心材或商业获得的含有hematein的药物组合物。 由于唾液酸显示低密度脂蛋白抗氧化活性，显着降低血液中的胆固醇，强烈抑制肝微粒体ACAT活性，可有效用于动脉粥样硬化和高脂血症的预防和治疗。 构成：用于预防和治疗哺乳动物动脉粥样硬化和高脂血症的组合物含有有效量的hematein和药学上可接受的载体作为活性成分。 半乳糖苷抑制酰基辅酶A：胆固醇酰基转移酶的活性或作为低密度脂蛋白抗氧化剂，以预防和治疗高脂血症。
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公开(公告)号：KR100362940B1
公开(公告)日：2002-11-30
申请号：KR1020020027396
申请日：2002-05-17
Applicant: 한국과학기술연구원
IPC: A61K31/335
Abstract: 본발명은유효량의헤마테인을함유하는고지혈증및 동맥경화증예방및 치료용조성물에관한것으로, 본발명의조성물은의약용및 식품용조성물을포함한다. 헤마테인은 LDL-항산화제활성을나타내며, 혈중콜레스테롤을현저하게감소시키고, 간마이크로좀 ACAT 활성을강력하게저해하므로, 헤마테인을함유하는본 발명의조성물은고지혈증및 동맥경화증의치료및 예방을위해유용하게사용될수 있다.
Abstract translation: 本发明涉及含有有效量的伴侣H.的高脂血症和动脉硬化的预防和治疗组合物，包括本发明和医疗食物组合物为的组合物。 H.伴侣-在LDL-抗氧化剂是指活性，显著降低血液中的胆固醇，将含有微粒体肝ACAT本发明的组合物中，H.配合，从而强烈地抑制高脂血症和动脉粥样硬化的治疗和预防的活性 可以有用地用于。
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公开(公告)号：KR1020000073945A
公开(公告)日：2000-12-05
申请号：KR1019990017558
申请日：1999-05-17
Applicant: 한국과학기술연구원
IPC: A61K31/335
Abstract: PURPOSE: A haematin substance has characteristically an LDL(low density lipoprotein)-antioxidation, reduces the concentration of cholesterol in blood, and inhibits the activity of liver microsome ACAT(acyl-CoA: cholesterol acyl-transferase). Thereby, the pharmaceutical composition containing the haematin has an excellent effect for treating or protecting specific diseases such as hyperlipidemia or arteriosclerosis. CONSTITUTION: The haematin used is conventionally derivable from Heartwood of Caesalpinia sappan, or is available industrially. The pharmaceutical composition is used to treat or protect hyperlipidemia or arteriosclerosis by using usual haematin in drug, beverage or food.
Abstract translation: 目的：血红素物质具有LDL（低密度脂蛋白） - 抗氧化作用，降低血液中胆固醇的浓度，并抑制肝微粒体ACAT（酰基辅酶A：胆固醇酰基转移酶）的活性。 因此，含有血红素的药物组合物对治疗或保护特异性疾病如高脂血症或动脉硬化具有优异的效果。 构成：所使用的血红素通常衍生自凯撒山茱萸的心材，或在工业上可用。 药物组合物用于通过在药物，饮料或食物中使用普通血红素来治疗或保护高脂血症或动脉硬化。
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