公开(公告)号：KR101232261B1

公开(公告)日：2013-02-15

申请号：KR1020100006000

申请日：2010-01-22

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  박미란 ,  포타트리무디

IPC: A61L27/14 ,  A61L27/54 ,  A61L27/52

Abstract: 화학적 가교결합이 가능한 포스파젠계 고분자의 생체재료로서의 용도, 생리활성물질이 공유 결합되어 있는 화학적 가교결합이 가능한 포스파젠계 고분자 및 이의 생체재료로서의 용도, 및 그 제조 방법이 제공된다. 상기 화학적 가교결합은 자외선 조사, 및/또는 가교제, 및/또는 첨가제, 및/또는 효소 및/또는, 1종 이상 고분자의 혼합에 의한 것일 수 있다.

公开(公告)号：KR1020110086326A

公开(公告)日：2011-07-28

申请号：KR1020100006000

申请日：2010-01-22

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  박미란 ,  포타트리무디

IPC: A61L27/14 ,  A61L27/54 ,  A61L27/52

CPC classification number: A61L27/14 ,  A61L27/52 ,  A61L27/54

Abstract: PURPOSE: A polyphosphazene composition for biomaterials is provided to make chemical crosslinking that bioactive substance is covalently bonded possible. CONSTITUTION: A polyphosphazene composition for biomaterials can be used for bioactive substance transfer materials, orthopedic surgery materials, biomaterials for histotechnology, blood vessel absorption prevention materials, and biomaterials by forming gel having more strong intensity through ultraviolet ray irradiation, crosslinking agent addition, additive addition, enzyme addition, and mixing of phosphazene polymer.

Abstract translation: 目的：提供用于生物材料的聚磷腈组合物，以使生物活性物质共价结合成化学交联。 构成：用于生物材料的聚磷腈组合物可用于生物活性物质转移材料，矫形手术材料，组织技术生物材料，血管吸收防止材料和生物材料，通过形成通过紫外线照射具有更强强度的凝胶，交联剂添加剂，添加剂添加剂 ，酶添加和磷腈聚合物的混合。

公开(公告)号：KR1020080110473A

公开(公告)日：2008-12-18

申请号：KR1020080040662

申请日：2008-04-30

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  포타트리무디 ,  이선미

IPC: C08G79/02 ,  C08J3/075 ,  A61K47/30

CPC classification number: C08G79/025 ,  A61K9/06 ,  A61K47/34 ,  C08G65/33306 ,  C08G2650/50 ,  C08J3/075 ,  C08J3/246 ,  C08J3/28 ,  C08J2385/02 ,  C08L85/02 ,  C08L2203/02

Abstract: A polymer hydrogel is provided to form chemical cross-linkage in mixing and to ensure excellent strength and sol-gel movement by containing a phosphazene-based polymer in a constant concentration. A phosphazene-based polymer has a structure of the chemical formula 1. In the chemical formula 1, P has a value of 7 - 50; in NHCH(R1)CO2R2, R1 is selected from a group consisting of H, CH3, CH2SH, CH(CH3) 2, CH2 CH(CH3)2, CH(CH3) C2H5, CH2CH2SCH3, CH2C6H5, CH2C6H4OH and CH2C2NH2C6H4 and R2 is selected from a group consisting of CH3, C2H5, C3H7, C4H9, CH2C6H5 and CH2CHCH2; R3 is CH(W); R4 is selected from a group consisting of CO2, CONHCH(X)CO2CO2, and CH2CO2 and CO2CH(CH3)CO2; R4 is selected from a group consisting of CO2, CONHCH(X)CO2CO2, CH2CO2 and CO2CH(CH3)CO2; R5 is selected from a group consisting of H, CH3 and C2H5; and W and X are selected from a group consisting of H, CH3, CH(CH3)2, CH2CH(CH3)2, CH(CH3)C2H5, CH2CH2SCH3, CH2C6H5, CH2C2NH2C6H4, CO2C2H5, (CH2)2CO2C2H5, CH2OH, CH(CH3)OH, CH2C6H4OH, CH2COOH, CH2CH2COOH, CH2CONH2, C4H8NH2, C3H6 NHC(=NH)NH2, CH2C3N2H3 and CH2SH.

Abstract translation: 提供聚合物水凝胶以在混合中形成化学交联，并通过含有恒定浓度的磷腈基聚合物来确保优异的强度和溶胶 - 凝胶运动。 磷腈基聚合物具有化学式1的结构。在化学式1中，P的值为7-50; 在NHCH（R1）CO2R2中，R1选自H，CH3，CH2SH，CH（CH3）2，CH2CH（CH3）2，CH（CH3）C2H5，CH2CH2SCH3，CH2C6H5，CH2C6H4OH和CH2C2NH2C6H4，R2是 选自由CH 3，C 2 H 5，C 3 H 7，C 4 H 9，CH 2 C 6 H 5和CH 2 CHCH 2组成的组; R3是CH（W）; R 4选自CO 2，CONHCH（X）CO 2 CO 2和CH 2 CO 2和CO 2 CH（CH 3）CO 2; R 4选自CO 2，CONHCH（X）CO 2 CO 2，CH 2 CO 2和CO 2 CH（CH 3）CO 2; R5选自H，CH3和C2H5; 并且W和X选自H，CH 3，CH（CH 3）2，CH 2 CH（CH 3）2，CH（CH 3）C 2 H 5，CH 2 CH 2 SCH 3，CH 2 C 6 H 5，CH 2 C 2 NH 2 C 6 H 4，CO 2 C 2 H 5，（CH 2）2 CO 2 C 2 H 5，CH 2 OH，CH（ CH3）OH，CH2C6H4OH，CH2COOH，CH2CH2COOH，CH2CONH2，C4H8NH2，C3H6 NHC（= NH）NH2，CH2C3N2H3和CH2SH。