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公开(公告)号：KR1020120121937A
公开(公告)日：2012-11-07
申请号：KR1020110039143
申请日：2011-04-26
Applicant: 한국과학기술연구원
CPC classification number: C07D239/60 , C07C39/373 , C07C47/565 , C07C49/248 , C07C49/747 , C07C69/732 , C07C69/94 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07C2602/08 , C07D403/10 , Y10T436/206664
Abstract: PURPOSE: A fluorescent nanoprobe for detecting hydrogen peroxide is provided to be quickly embodied by organic base in nanoparticles, and to be used for detecting sulfuric acid in rear time and to be used for cell-imaging in vivo-imaging, chemical analysis, etc. CONSTITUTION: A fluorescent nanoprobe for detecting hydrogen peroxide is represented by chemical formula 1. In chemical formula 1, A is an electron-accepting substituent selected ester, aldehyde, nitrile, nitrobenzene, sulfonated benzene, indane, babituric acid, and derivatives thereof, an electron-accepting substituent. The fluorescent nanoprobe comprises the sulfonated benzene compound and water. A manufacturing method of the fluorescent nanoprobe comprises: a step of mixing sulfonated benzene compound represented by chemical formula 3 and organic solvent; and a step of obtaining fluoresncent nanoprobe by removing the organic solvent.
Abstract translation: 目的：提供一种用于检测过氧化氢的荧光探针，可以通过纳米颗粒中的有机碱快速实现，并用于后期检测硫酸，并用于体内成像，化学分析等细胞成像。 组成：用于检测过氧化氢的荧光纳米探针由化学式1表示。在化学式1中，A是选择的电子接受性取代基酯，醛，腈，硝基苯，磺化苯，茚满，巴布酸及其衍生物， 受电子取代基。 荧光纳米探针包含磺化苯化合物和水。 荧光纳米探针的制造方法包括：将由化学式3表示的磺化苯化合物与有机溶剂混合的步骤; 以及通过除去有机溶剂获得荧光剂纳米探针的步骤。
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公开(公告)号：KR101311224B1
公开(公告)日：2013-09-25
申请号：KR1020110039143
申请日：2011-04-26
Applicant: 한국과학기술연구원
CPC classification number: C07D239/60 , C07C39/373 , C07C47/565 , C07C49/248 , C07C49/747 , C07C69/732 , C07C69/94 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07C2602/08 , C07D403/10 , Y10T436/206664
Abstract: 본 발명은 과산화수소와 반응하여 형광을 발생하는 술폰화 벤젠 화합물과 과산화수소를 실시간으로 검출하는데 사용 가능한 수계분산 형광 나노 프로브와 그 제조방법에 관한 것으로서, 본 발명의 형광 나노 프로브는 아래의 술폰화 벤젠화합물 및 물을 포함하는 것이다.
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公开(公告)号：KR101823490B1
公开(公告)日：2018-01-30
申请号：KR1020160115883
申请日：2016-09-08
Applicant: 한국과학기술연구원
CPC classification number: A61K49/226 , A61K47/34 , G01N21/64 , C08G73/0206 , A61K49/0019 , A61K49/0093 , C08J3/075 , C08J3/24 , C08L79/02 , C08L2203/02
Abstract: 본발명은옥사미드결합에의해가교결합된폴리아민계고분자를포함하는나노겔, 상기나노겔의제조방법, 상기나노겔을포함하는초음파영상용조영제, 상기조영제를포함하는염증성질환의초음파진단용조성물, 상기조영제의제조방법, 및상기초음파진단용조성물을이용한염증성질환의진단을위한정보의제공방법에관한것이다.
Abstract translation: 本发明草酰胺通过键连接的聚胺系纳米凝胶的交联中，纳米凝胶的制造方法，其包括聚合物，造影剂，其包含纳米凝胶超声成像，炎性疾病，包括造影剂的超声波诊断组合物， 制造造影剂的方法以及使用超声波诊断组合物提供用于诊断炎性疾病的信息的方法。
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