公开(公告)号：KR100454712B1

公开(公告)日：2004-11-05

申请号：KR1020010047010

申请日：2001-08-03

Applicant: 한국과학기술연구원

Inventor： 박태진 ,  이중기 ,  현명호

IPC: C07F7/08

Abstract: PURPOSE: Provided are chiral stationary phases which are useful for the separation of two of optical isomers composing racemic compounds, chiral columns filled with the chiral stationary phases and a process for producing the chiral stationary phases. CONSTITUTION: The chiral stationary phase(CSP1) is represented by the formula(1) and manufactured by the steps of: synthesizing an amino acid anilide derivative by dissolving an optically active amino acid derivative then adding an aniline derivative thereto; synthesizing an alkenoyl amino acid anilide derivative by dissolving the amino acid anilide derivative then adding alkenoyl chloride having double bond thereto; synthesizing silyl compound of the alkenoyl amino acid anilide derivative by dissolving the alkenoyl amino acid anilide derivative and adding a silylating agent thereto; and binding the silyl compound of the alkenoyl amino acid anilide derivative to silica gel removed from water by reflux to synthesize CSP1 of the formula(1).

Abstract translation: 目的：提供手性固定相，其可用于分离构成外消旋化合物的两种光学异构体，填充有手性固定相的手性柱以及制备手性固定相的方法。 构成：手性固定相（CSP1）由式（1）表示，并通过以下步骤制备：通过溶解光学活性氨基酸衍生物然后向其中加入苯胺衍生物合成氨基酸苯胺衍生物; 通过溶解氨基酸N-酰苯胺衍生物然后加入具有双键的链烯酰氯合成烯酰氨基酸N-酰苯胺衍生物; 通过溶解烯酰氨基酸N-酰苯胺衍生物并向其中加入甲硅烷基化剂合成烯酰氨基酸N-酰苯胺衍生物的甲硅烷基化合物; 并将烯酰氨基酸N-酰苯胺衍生物的甲硅烷基化合物结合到通过回流从水中除去的硅胶上以合成式（1）的CSP1。

公开(公告)号：KR1020030012658A

公开(公告)日：2003-02-12

申请号：KR1020010047010

申请日：2001-08-03

Applicant: 한국과학기술연구원

Inventor： 박태진 ,  이중기 ,  현명호

IPC: C07F7/08

CPC classification number: C07C231/20 ,  B01D15/3833

Abstract: PURPOSE: Provided are chiral stationary phases which are useful for the separation of two of optical isomers composing racemic compounds, chiral columns filled with the chiral stationary phases and a process for producing the chiral stationary phases. CONSTITUTION: The chiral stationary phase(CSP1) is represented by the formula(1) and manufactured by the steps of: synthesizing an amino acid anilide derivative by dissolving an optically active amino acid derivative then adding an aniline derivative thereto; synthesizing an alkenoyl amino acid anilide derivative by dissolving the amino acid anilide derivative then adding alkenoyl chloride having double bond thereto; synthesizing silyl compound of the alkenoyl amino acid anilide derivative by dissolving the alkenoyl amino acid anilide derivative and adding a silylating agent thereto; and binding the silyl compound of the alkenoyl amino acid anilide derivative to silica gel removed from water by reflux to synthesize CSP1 of the formula(1).

Abstract translation: 目的：提供手性固定相，其可用于分离构成外消旋化合物的两种光学异构体，装有手性固定相的手性柱和用于产生手性固定相的方法。 构成：手性固定相（CSP1）由式（1）表示，通过以下步骤制造：通过将光学活性氨基酸衍生物溶解，然后加入苯胺衍生物合成氨基酸酰苯胺衍生物; 通过溶解氨基酸苯胺衍生物然后加入具有双键的烯酰氯合成烯酰基氨基酸苯胺衍生物; 通过将烯酰基氨基酸酰苯胺衍生物溶解并加入甲硅烷基化剂合成烯酰基氨基酸酰苯胺衍生物的甲硅烷基化合物; 并将烯酰基氨基酸苯胺衍生物的甲硅烷基化合物与通过回流从水中除去的硅胶结合，合成式（1）的CSP1。