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    불안장애 치료제 효과 검증 모델 동물로서의 ＰＬＣβ４돌연변이 생쥐
    1.
    发明公开
    불안장애 치료제 효과 검증 모델 동물로서의 ＰＬＣβ４돌연변이 생쥐 失效
    PLCbeta4 MUTANT MICE作为测试麻醉药物的模型

    公开(公告)号：KR1020090081232A

    公开(公告)日：2009-07-28

    申请号：KR1020080007202

    申请日：2008-01-23

    Applicant: 한국과학기술연구원

    Inventor： 신희섭 ,  이석찬 ,  김희수 ,  최석우 ,  홍인기

    IPC: A01K67/027

    CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356

    Abstract: Provided are a method or a use of using a PLC beta4 knock-out animal as an anxiety disorder animal model, and a method of screening anxiety disorder-preventing and treating agents using the animal. A method of using a PLC beta4 knock-out animal as an anxiety disorder animal model comprises using an animal in which a PLC beta4(phospholipase beta4) gene representing a lack in the memory disappearing capability is knocked-out as an anxiety disorder animal model. A use of using a PLC beta4 knock-out animal as an anxiety disorder animal model comprises using an animal in which a PLC beta4(phospholipase beta4) gene representing a lack in the memory disappearing capability is knocked-out as an anxiety disorder animal model. A method of screening anxiety disorder-preventing and treating agents comprises the steps of: injecting candidate materials of the anxiety disorder-preventing and treating agents into an animal in which a PLC beta4(phospholipase beta4) gene is knocked-out; testing the memory disappearing capability of the animal; and sorting the candidate material that has attentively recovered the memory disappearing capability as compared with a control group into which the candidate materials have not been injected.

    Abstract translation: 提供了使用PLC beta4敲除动物作为焦虑障碍动物模型的方法或使用，以及使用该动物筛选焦虑障碍预防和治疗剂的方法。 使用PLCβ4敲除动物作为焦虑障碍动物模型的方法包括使用其中表示缺乏记忆消失能力的PLCβ4（磷脂酶β4）基因作为焦虑障碍动物模型被敲除的动物。 使用PLCβ4敲除动物作为焦虑症动物模型包括使用其中表示缺乏记忆消失能力的PLCβ4（磷脂酶β4）基因作为焦虑障碍动物模型被敲除的动物。 筛选焦虑障碍预防和治疗剂的方法包括以下步骤：将焦虑障碍预防和治疗剂的候选材料注射到其中敲除了PLCβ4（磷脂酶β4）基因的动物中; 测试动物的记忆消失能力; 并且与候选材料未被注入的对照组相比，对已经认真地恢复记忆消失能力的候选材料进行排序。

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