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公开(公告)号：KR1020000067074A
公开(公告)日：2000-11-15
申请号：KR1019990014564
申请日：1999-04-23
IPC: C07C69/757 , C12N15/00
Abstract: PURPOSE: Novel aklavinone derivatives prepared by transforming biosynthetic variants with a vector containing aklavinone C-11 hydroxylase gene separated from Streptomyces sp and fermenting transformer thereof and process for producing the same are provided which can be effectively used for an antibiotic. CONSTITUTION: 2,11-Dihydroxyaklavinone of formula 1 is used in the manufacture of various new anthracycline antibiotics through bioconversion. Thus, 2,11-dihydroxyaklavinonecycline as anthracycline antibiotics is prepared by using the compound as a precursor, has low toxicity against a cell and is safer than conventional antibiotics.
Abstract translation: 目的：提供通过用链霉菌sp和发酵变压器分离的含有aklavinone C-11羟化酶基因的载体转化生物合成变体制备的新型aklavinone衍生物及其生产方法，其可有效用于抗生素。 构成：式1的2,11-二羟基喹喔啉通过生物转化用于制备各种新的蒽环类抗生素。 因此，通过使用该化合物作为前体制备作为蒽环类抗生素的2,11-二羟基喹诺酮类，对细胞毒性低，比常规抗生素更安全。
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公开(公告)号：KR1019970061260A
公开(公告)日：1997-09-12
申请号：KR1019960002509
申请日：1996-02-02
IPC: A61K36/286 , A61P3/10 , A61P3/04
Abstract: 본 발명은 탄수화물 대사에 필수적인 효소군인
-글루코시다제 효소들의 가수분해 작용을 억제하여 인체와 동물에서 탄수화물 대사를 조절함으로서 식후 혈중 포도당 농도의 급격한 상승을 조절하여 당뇨병, 비만증 및 고지방증과 같은 질환의 치료 및 합병증 조절에 유효한 닭의장풀 추출물 및 이의 제조 방법에 관한 것이다.
또한 닭의장풀 추출물로부터 1-데옥시노지리마이신, 2,5-디하이드록시메틸 3,4-디하이드록시 피롤리딘, 호모노지리마이신을 분리·정제하는 방법에 관한 것이다.-
公开(公告)号：KR100343394B1
公开(公告)日：2002-07-15
申请号：KR1019990014564
申请日：1999-04-23
IPC: C07C69/757 , C12N15/00
Abstract: 본발명은신규아클라비논유도체와미생물을이용한제조방법, 그리고상기화합물의제조에이용되는형질전환체에관한것으로, 보다상세하게는스트렙토마이세스속 균주로부터분리된아클라비논 C-11 히드록실라제유전자를포함하는벡터로생합성변이주를형질전환시킨다음, 그형질전환체를배양하여하기화학식 1의신규아클라비논유도체인 2,11-디히드록시아클라비논을제조하는데, 상기화합물은새로운안트라사이클린계항생물질을제조하기위한전구체로사용될수 있으며, 생물전환의방법으로얻어지는안트라사이클린계항생제는세포독성이낮아부작용이적은효과적인항생제로이용될수 있다.
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公开(公告)号：KR100192835B1
公开(公告)日：1999-06-15
申请号：KR1019960002509
申请日：1996-02-02
IPC: A61K36/286 , A61P3/10 , A61P3/04
Abstract: 본 발명은 탄수화물 대사에 필수적인 효소군인 α-글루코시다제 효소들의 가수분해 작용을 억제하여 인체와 동물에서 탄수화물 대사를 조절함으로서 식후 혈중 포도당 농도의 급격한 상승을 조절하여 당뇨병, 비만증 및 고지방증과 같은 질환의 치료 및 합병증 조절에 유효한 닭의장풀 추출물 및 이의 제조 방법에 관한 것이다.
또한 닭의장풀 추출물로부터 1-데옥시노지리마이신, 1-데옥시만노지리마이신, 2,5-디하이드록시메틸 3,4-디하이드록시 피롤리딘, 호모노지리마이신을 분리·정제하는 방법에 관한 것이다.-
5.发明公开고분자 다당 바인더에 컨쥬게이트된 락토바실러스 람노서스 RHT-3201, 및 이의 아토피 예방 및 치료 용도 有权大分子多糖结合的Lactobacillus RHAMNOSUS RHT-3201及其在预防和治疗原发性病变中的应用
公开(公告)号：KR1020150127436A
公开(公告)日：2015-11-17
申请号：KR1020140054237
申请日：2014-05-07
Applicant: 일동홀딩스(주)
CPC classification number: C12N1/20 , A23L2/52 , A23L33/00 , A23L33/10 , A23V2002/00 , A23Y2220/73 , A61K35/74
Abstract: 본발명은고분자다당바인더에컨쥬게이트된열사락토바실러스람노서스, 이의제조방법및 이의용도에관한것이다. 본발명의고분자다당바인더에컨쥬게이트된열사락토바실러스람노서스는아토피질환의치료효과가뛰어나며, 특히기존의유산균제가가지고있는장점막부착경쟁력을월등히개선하여, 스테로이드계약물과동등한수준으로아토피성피부염의예방, 개선또는치료효과를나타내기때문에산업상이용가능성이크다.
Abstract translation: 本发明涉及与多糖聚合物粘合剂缀合的热灭活的鼠李糖乳杆菌，其制备方法及其用途。 与本发明的多糖聚合物粘合剂结合的热灭活的鼠李糖乳杆菌对特应性疾病具有优异的治疗效果，特别是具有高的工业可利用性，因为现有乳酸菌具有的膜粘附竞争力显着提高，从而显示出 预防，减轻或治疗特应性皮炎与类固醇类药物水平相同的效果。
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Patent Agency Ranking
公开(公告)号：KR1020140115149A
公开(公告)日：2014-09-30
申请号：KR1020130029876
申请日：2013-03-20
Applicant: 일동홀딩스(주)
IPC: C12P19/04 , C08B37/08 , A61K31/728
CPC classification number: C08B37/0072 , A61K31/728 , A61L27/20 , A61L27/58 , A61L31/042 , A61L31/148 , C08L5/08 , C12P19/26 , C12R1/46 , C12P19/04
Abstract: The present invention relates to a method for manufacturing hyaluronic acid having low dissolving speed in the body and a composition for adhesion prevention comprising hyaluronic acid manufactured thereby. More specifically provided are a method for manufacturing hyaluronic acid having low dissolving speed in the body including a step for cultivating streptococcus dysgalactiae ID9103 strains (KCTC11818BP) in a culture ground where carbon source and nitrogen source are included and a composition for adhesion prevention comprising hyaluronic acid manufactured thereby. Hyaluronic acid manufactured by the manufacturing method of the present invention has an excellent effect in adhesion prevention due to having low dissolving speed in the body as 4 million Da to 10 million Da of highly polymerized hyaluronic acid. A composition of the present invention for adhesion prevention comprising hyaluronic acid manufactured by the manufacturing method of the present method can ameliorate problems of the existing composition for adhesion prevention including cross-linker and compound and problems of the existing hyaluronic acid.
Abstract translation: 本发明涉及一种在体内具有低溶解速度的透明质酸的制造方法以及由此制造的透明质酸组合物。 更具体地提供了一种在体内制造具有低溶解速度的透明质酸的方法，包括在含有碳源和氮源的培养基中培养不育乳杆菌ID9103菌株（KCTC11818BP）的步骤和包含透明质酸的粘合预防组合物 由此制造。 通过本发明的制造方法制造的透明质酸由于在体内具有低溶解速度而具有优异的粘合防止效果，作为400万Da至1000万Da的高度聚合的透明质酸。 通过本发明的制造方法制造的包含透明质酸的本发明的组合物可以改善包括交联剂和化合物在内的现有的粘合防止组合物的问题和现有的透明质酸的问题。
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公开(公告)号：KR1020130067682A
公开(公告)日：2013-06-25
申请号：KR1020110134486
申请日：2011-12-14
Applicant: 일동홀딩스(주)
Abstract: PURPOSE: A quadruple-coated lactic acid bacterium is provided to ensure acid and bile acid resistance, low bacterial death rate by high or low temperature, and to prevent loss of inherent physiologically active function of the bacteria by mixing lactic acid bacteria with a water soluble polymer, hyaluronic acid, a coating agent with a porous particle, and a protein, and quadruple-coating. CONSTITUTION: A method for preparing quadruple-coated lactic acid bacteria comprises: a step of mixing a water soluble polymer in lactic acid bacteria and primarily coating the lactic acid bacteria; a step of mixing the lactic acid bacteria with hyaluronic acid and secondarily coating the lactic acid bacteria; a step of mixing the lactic acid bacteria with a coating agent with a porous particle, and thirdly coating the lactic acid bacteria; and a step of mixing the lactic acid bacteria with a protein.
Abstract translation: 目的：提供四层乳酸菌，以确保酸耐胆汁酸，高低温细菌死亡率低，并通过将乳酸菌与水溶性混合来防止细菌固有的生理活性功能丧失 聚合物，透明质酸，具有多孔颗粒的包衣剂和蛋白质，以及四重涂层。 构成：制备四重乳酸菌的方法包括：将水溶性聚合物混合在乳酸菌中并主要包衣乳酸菌的步骤; 将乳酸菌与透明质酸混合并二次涂布乳酸菌的步骤; 将乳酸菌与包衣剂与多孔质粒混合的步骤，第三次涂布乳酸菌; 以及将乳酸菌与蛋白质混合的步骤。
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公开(公告)号：KR1020110035312A
公开(公告)日：2011-04-06
申请号：KR1020090092965
申请日：2009-09-30
Applicant: 일동홀딩스(주)
IPC: A61K31/718 , A61P9/14 , A61K9/02 , A61K9/06
CPC classification number: A61K31/728 , A61K9/02 , A61K9/06 , Y10S514/882
Abstract: PURPOSE: A composition containing hyaluronic acid or salt thereof for treating hemorrhoid is provided to heal scar and to ensure skin protection, moisturizing, and tissue regeneration without side effects. CONSTITUTION: A pharmaceutical composition for treating hemorrhoid contains 0.01-5% of hyaluronic acid or salt thereof as an active ingredient. The sodium hyaluronic acid is prepared by dissolving in a sterilized saline solution. The pharmaceutical composition is manufactured in the form of suppository, ointment, gel, or cream. A method for manufacturing the suppository comprises: a step of melting Witepsol over 50°C and adding hyaluronic acid; a step of removing pores at 40°C; and a step of pouring the solution into a frame and cooling at room temperature.
Abstract translation: 目的：提供含有用于治疗痔疮的透明质酸或其盐的组合物以愈合瘢痕并确保皮肤保护，保湿和组织再生而没有副作用。 构成：用于治疗痔疮的药物组合物含有0.01-5％的透明质酸或其盐作为活性成分。 将透明质酸钠溶解在无菌盐水溶液中制备。 药物组合物以栓剂，软膏剂，凝胶剂或霜剂的形式制备。 制造栓剂的方法包括：将Witepsol在50℃以上熔融并加入透明质酸的步骤; 在40℃下除去孔的步骤; 以及将溶液倒入框架中并在室温下冷却的步骤。
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公开(公告)号：KR100861181B1
公开(公告)日：2008-09-30
申请号：KR1020020015665
申请日：2002-03-22
Applicant: 일동홀딩스(주)
IPC: C12N1/20
Abstract: 본 발명은 전구체인 비타민 D3에 하이드록실기를 도입하여 활성형 비타민 D3를 생산하는 슈도노카르디아 아우토트로피카(
Pseudonocardia autotrophica ) ID9302에 관한 것으로써, 토양에서 분리한 야생균주 슈도노카르디아 아우토트로피카를 자외선, NTG, EtBr 등의 변이원으로 돌연변이시켜 각종 탄소원, 질소원, 기타 배지원의 최적화 시험과 배양 공정과 생물전환 공정을 개선함으로써 25-하이드록시비타민 D3와 칼시트리올을 고생산하는 것을 특징으로 한다.
비타민 D3, 칼시트리올, 생물전환, 슈도노카르디아, 자외선-
公开(公告)号：KR1020130067922A
公开(公告)日：2013-06-25
申请号：KR1020110134970
申请日：2011-12-14
Applicant: 일동홀딩스(주)
Abstract: PURPOSE: A microencapsulation method of spore-forming probiotics is provided to ensure excellent productivity and uniformity of a spore, and to enhance long-term preservation and regermination rates by the probiotics. CONSTITUTION: A method for preparing an autolysin-removed spore comprises a step of removing autolysin from entire spore by chemical shocks. A method for preparing thin film-coated microcapsulated spore-formed probiotics comprises: a step of performing primary thin film coating of the spore surface of the spore-forming probiotics using a water soluble polymer; and a step of secondarily microcapsulating. Polyvinyl pyrrolidone(PVP) is used as a thin film coating substrate for improving durability and stability of the spore.
Abstract translation: 目的：提供孢子形成益生菌的微囊化方法，以确保孢子的优良生产力和均匀性，并通过益生菌增强长期保存和再生率。 构成：用于制备自溶蛋白去除孢子的方法包括通过化学冲击从整个孢子中除去自溶素的步骤。 一种制备薄膜包衣的微囊孢子形成益生菌的方法包括：使用水溶性聚合物进行孢子形成益生菌的孢子表面的初级薄膜包衣的步骤; 和二次微胶囊化的步骤。 使用聚乙烯吡咯烷酮（PVP）作为薄膜涂层基材，用于提高孢子的耐久性和稳定性。
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