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Patent Agency Ranking
公开(公告)号：KR1020110134790A
公开(公告)日：2011-12-15
申请号：KR1020100054571
申请日：2010-06-09
Applicant: 한국과학기술원
IPC: A61L27/54 , A61L27/38 , A61K31/137 , A61F2/02 , C12N5/071
CPC classification number: A61L27/54 , A61F2/02 , A61K31/137 , A61L27/3895 , C12N5/0602
Abstract: PURPOSE: A substrate for cell adhesion having modified surface and a manufacturing method thereof are provided to improve cell adhesion about an artificial scaffold for tissue regeneration. CONSTITUTION: A substrate for cell adhesion having modified surface is selected from a group consisting of: an inorganic substance including glass, titanium, silicon, aluminum, gold, and the like; a polymer and poiycaprolactone including polydimethylsiloxane, polystyrene, polymethyl methacrylate, polytetrafluoroethylene, polyethylene, polyurethane, cellulose, silicon rubber, and the like; and polymer nanofiber including Poly(L-lactic acid), poly(lactic-glycol acid), poly(vinylidene fluoride), polyacrylic acid, and the like.
Abstract translation: 目的：提供具有改性表面的细胞粘附用基材及其制造方法，以改善细胞在人造骨架上的粘附，用于组织再生。 构成：具有改性表面的细胞粘附用基材选自：包括玻璃，钛，硅，铝，金等的无机物质; 包括聚二甲基硅氧烷，聚苯乙烯，聚甲基丙烯酸甲酯，聚四氟乙烯，聚乙烯，聚氨酯，纤维素，硅橡胶等的聚合物和聚己内酯; 和包含聚（L-乳酸），聚（乳酸 - 乙二醇酸），聚（偏二氟乙烯），聚丙烯酸等的聚合物纳米纤维。
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公开(公告)号：KR101222019B1
公开(公告)日：2013-01-14
申请号：KR1020110086083
申请日：2011-08-26
Applicant: 한국과학기술원
CPC classification number: C01B32/23 , A61L27/08 , A61L27/12 , C01F11/186
Abstract: PURPOSE: A graphene biomineral hybrid film and a manufacturing method of the same are provided to increase the viability of osteoblast by cultivating the osteoblast using the graphene biomineral hybrid film. CONSTITUTION: A manufacturing method of a graphene biomineral hybrid film includes the following steps: carbon dioxide is mixed with a solution containing a graphene oxide and calcium chloride; the mixture is filtered and dried to form a spherical graphene oxide-calcium carbonate(GO_CaCO_3) baterite; the spherical graphene oxide-calcium carbonate baterite is reduced to manufacture a graphene oxide-calcium carbonate(GOCaCO_3) hybrid film; and the thickness of the graphene oxide-calcium carbonate hybrid film is in a range between 50 and 300um.
Abstract translation: 目的：提供石墨烯生物矿物杂合膜及其制造方法，以通过使用石墨烯生物矿物混合膜培养成骨细胞来增加成骨细胞的活力。 构成：石墨烯生物矿物混合膜的制造方法包括以下步骤：将二氧化碳与含有氧化石墨烯和氯化钙的溶液混合; 将混合物过滤并干燥以形成球形石墨烯氧化物 - 碳酸钙（GO_CaCO_3）贝类; 氧化球形氧化碳 - 碳酸钙颗粒被还原成制造石墨烯氧化物 - 碳酸钙（GOCaCO_3）混合膜; 并且氧化石墨烯 - 碳酸钙混合膜的厚度在50和300um之间的范围内。
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公开(公告)号：KR1020090046576A
公开(公告)日：2009-05-11
申请号：KR1020070112804
申请日：2007-11-06
Applicant: 한국과학기술원
IPC: G01N33/15
Abstract: 본 발명은 퇴행성 신경질환 치료제의 스크리닝 방법에 관한 것으로, 더욱 자세하게는 아밀로이드 단백질 침착물이 형성된 고체기판 상에서 퇴행성 신경질환 치료제 후보물질의 존재 하에 신경세포를 배양하는 것을 특징으로 하는 퇴행성 신경질환 치료제의 스크리닝 방법에 관한 것이다.
본 발명에 따르면, 기존의
in vivo 에서 수행하였던 아밀로이드 단백질 침작에 의한 신경질환 치료제의 스크리닝을 고체기판 상에서 경제적이고, 간편하게 수행할 수 있어, 퇴행성 신경질환 치료제개발에 매우 유용하다.
아밀로이드 단백질, 알츠하이머, 헌팅톤, 프리온, 광우병, 신약개발-
公开(公告)号：KR1020110128637A
公开(公告)日：2011-11-30
申请号：KR1020100048179
申请日：2010-05-24
Applicant: 한국과학기술원
Abstract: PURPOSE: A polymer coating substrate-hydroxyapatite composite having a catechol radical, and a producing method thereof are provided to offer the excellent adhesive property of the composite for any kind of substrates to users . CONSTITUTION: A producing method of a polymer coating substrate-hydroxyapatite composite having a catechol radical comprises the following steps: coating the surface of a substrate using a polymer having the catechol radical; and forming a hydroxyapatite layer on the substrate. The polymer having the catechol radical is selected from the group consisting of polydopamine, poly(norepinephrine), PEG-catechol, and PEI-catechol.
Abstract translation: 目的：提供具有儿茶酚基团的聚合物涂层基质 - 羟基磷灰石复合物及其制备方法，以向用户提供用于任何种类基材的复合材料的优异粘合性。 构成：具有邻苯二酚基团的聚合物涂覆基质 - 羟基磷灰石复合物的制备方法包括以下步骤：使用具有儿茶酚基团的聚合物涂覆基底的表面; 并在基底上形成羟基磷灰石层。 具有儿茶酚基的聚合物选自聚多巴胺，聚（去甲肾上腺素），PEG-儿茶酚和PEI-儿茶酚。
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