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    비고리 피리미딘 유도체의 제조방법
    1.
    发明授权
    비고리 피리미딘 유도체의 제조방법 失效
    用于制备ACYCLIC吡嗪衍生物的方法

    公开(公告)号：KR1019900008169B1

    公开(公告)日：1990-11-05

    申请号：KR1019880013576

    申请日：1988-10-18

    Applicant: 한국과학기술원

    Inventor： 김용해 ,  김중영 ,  이춘호

    IPC: C07D239/32

    Abstract: Acyclic pyrimidine derivatives of formula (I) are prepared by reacting a cpd. of formula (II) with 2-acetoxyethyl acetoxymethylether or o-chloromethyl-1,3-di-o-benzylglycerol in the presence of cesium iodide and acetonitrile solvent. In the formulas, Z= 2acetoxyethoxymethyl or 1,3-di-o-benzylpropoxymethyl; X= S or O; R1, R2 and R3 each= H, methyl, amine, O or F. (I) have antiviral, anticancer and antibacterial activities.

    Abstract translation: 通过使cpd反应制备式（I）的非环嘧啶衍生物。 式（II）的化合物与2-乙酰氧基乙基乙酰氧基甲基醚或邻氯甲基-1,3-二-O-苄基甘油在碘化铯和乙腈溶剂存在下反应。 在式中，Z = 2-乙酰氧基乙氧基甲基或1,3-二邻 - 苄基丙氧基甲基; X = S或O; R1，R2和R3各自为H，甲基，胺，O或F.（I）具有抗病毒，抗癌和抗菌活性。

    비고리 퓨린유도체의 제조방법
    2.
    发明授权
    비고리 퓨린유도체의 제조방법 失效
    制备ACYCLIC衍生物的方法

    公开(公告)号：KR1019910000441B1

    公开(公告)日：1991-01-25

    申请号：KR1019880013575

    申请日：1988-10-18

    Applicant: 한국과학기술원

    Inventor： 김용해 ,  김중영

    IPC: C07D473/02

    Abstract: A process for preparing acyclic purine derivs. of formula (I) comprises an alkylation reaction of a cpd. of formula (II) with 2- acetoxyethyl acetoxymethylether or chloromethyl-1,3-di-o-benzylglycerol in the presence of cesium iodide and acetonitrile. In the formulas, Z=2-acetoxyethoxymethyl or 1,3-di-o- benzylpropoxymethyl; X= -SH, -NH2 or -H; and Y= -SH, -OH or NH2. (I) have antiviral, anticancer and anti-bacterial activity.

    Abstract translation: 制备无环嘌呤衍生物的方法。 式（I）的烷基化反应包括cpd的烷基化反应。 式（II）的化合物与2-乙酰氧基乙基乙酰氧基甲基醚或氯甲基-1,3-二-O-苄基甘油在碘化铯和乙腈存在下反应。 式中，Z = 2-乙酰氧基乙氧基甲基或1,3-二邻 - 苄基丙氧基甲基; X = -SH，-NH 2或-H; 和Y = -SH，-OH或NH 2。 （I）具有抗病毒，抗癌和抗菌活性。

    비고리 퓨린 유도체의 제조방법
    8.
    发明授权
    비고리 퓨린 유도체의 제조방법 失效
    制备嘌呤衍生物的方法

    公开(公告)号：KR1019900007245B1

    公开(公告)日：1990-10-06

    申请号：KR1019880003073

    申请日：1988-03-22

    Applicant: 한국과학기술원

    Inventor： 김용해 ,  김중영

    IPC: C07D473/02 ,  C07D473/18

    Abstract: Acyclic purine derivatives of formula (I) are prepared by silylating purine and alkylating the obtd. intermediate in the presence of zinc iodide and organic solvent. In (I), X is -SH or -NH2; Y is -SH or - NH2; Z is 2-acetoxyethylacetoxymethyl or oacetylmethyl-1,3-di-o- benzyl glycerol gp. (I) have antiviral, antitumor and antibacterial activity.

    Abstract translation: 式（I）的非环嘌呤衍生物通过使嘌呤甲硅烷基化和烷基化来制备。 在碘化锌和有机溶剂存在下中间体。 在（I）中，X是-SH或-NH 2; Y是-SH或-NH2; Z是2-乙酰氧基乙基乙酰氧基甲基或乙酰基甲基-1,3-二-O-苄基甘油gp。 （I）具有抗病毒，抗肿瘤和抗菌活性。

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