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Patent Agency Ranking
公开(公告)号：KR1020130030848A
公开(公告)日：2013-03-28
申请号：KR1020110094379
申请日：2011-09-20
Applicant: 한국과학기술원
CPC classification number: A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K31/337 , A61K47/34 , A61K47/42 , B82Y5/00
Abstract: PURPOSE: A nanocapsule is provided to maintain and improve physical stability in vivo and to encapsulate a material(insoluble drub and/or contrast agent). CONSTITUTION: A nanocapsule comprises an inner core and a shell surrounding the inner core. The shell is prepared by covalent bond of a non-ionic polymer and albumin. A method for manufacturing the nanocapsule comprises: a step of dissolving a non-ionic polymer in an organic solvent and preparing an oil-in-water emulsion; a step of treating the emulsion by ultrasonic wave and crosslinking albumin by covalent bond; and a step of evaporating remaining inorganic solvent. [Reference numerals] (AA) Organic solvent in which non-ionic polymer is dissolved with rarely soluble drug, a contrast medium, and others; (BB) Water with dissolved water soluble polymer; (CC) Oil-in-water emulsion; (DD) Crosslinking(pH 9); (EE) Organic solvent evaporating process; (FF) Water soluble polymer; (GG) Non-ionic polymer; (HH) Polymer nanocapsule containing rarely soluble drug and contrast medium; (II) Non-ionic polymer A-(X)_n; (JJ) Water soluble polymer B-(Y)_n; (KK) Rarely soluble drug, contrast medium
Abstract translation: 目的：提供纳米胶囊以维持和改善体内物理稳定性并包封材料（不溶性溶剂和/或造影剂）。 构成：纳米胶囊包括内芯和围绕内芯的外壳。 壳由非离子聚合物和白蛋白的共价键制备。 制造纳米胶囊的方法包括：将非离子聚合物溶解在有机溶剂中并制备水包油乳液的步骤; 通过超声波处理乳液和通过共价键交联白蛋白的步骤; 和蒸发剩余的无机溶剂的步骤。 （AA）非离子型聚合物与难溶性药物，造影剂等溶解的有机溶剂; （BB）水溶解水溶性聚合物; （CC）水包油乳液; （DD）交联（pH9）; （EE）有机溶剂蒸发过程; （FF）水溶性聚合物; （GG）非离子聚合物; （HH）含有极少可溶性药物和造影剂的聚合物纳米胶囊; （II）非离子聚合物A-（X）_n; （JJ）水溶性聚合物B-（Y）_n; （KK）难溶性药物，造影剂
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公开(公告)号：KR101333821B1
公开(公告)日：2013-11-29
申请号：KR1020100098401
申请日：2010-10-08
Applicant: 한국과학기술원 , 연세대학교 산학협력단
IPC: A61L29/16 , A61L29/04 , A61M25/10 , A61K31/337
Abstract: 본 발명에 따른 약물방출 풍선 카테터는 풍선 표면에 약물봉입 미세입자 및 생체적합성 고분자가 순차적 및 반복적으로 다층 코팅된 약물방출 풍선 카테터로서, 혈액의 정상 산도인 pH 7.4에서 가장 높은 약물방출량을 나타내고, 혈관 내에서 시술 부위까지 이동하는 동안 약물의 손실이 거의 없으며, 시술 부위에서 풍선 카테터를 팽창시킴으로써 부위 특이적(site-specific)으로 단시간 내에 약물을 다량 방출할 수 있고, 원하는 시술부위에서 풍선을 팽창시켰을 때 초기 약물 방출량이 매우 우수하므로, 관상동맥 질환 및 협착성 질환의 시술용 기구로 사용할 수 있다.
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公开(公告)号：KR101367940B1
公开(公告)日：2014-02-28
申请号：KR1020110094379
申请日：2011-09-20
Applicant: 한국과학기술원
Abstract: 본 발명은 (a) 내부 코어(inner core); 및 (b) 상기 내부 코어를 포위하는 쉘(shell)을 포함하는 나노캡슐(nano capsule)로서, 상기 쉘(shell)은 기능기가 도입된 비이온성 고분자 및 알부민이 공유결합에 의한 가교가 형성되어 이루어지는 것을 특징으로 하는 나노 캡슐(nano capsule) 및 상기 나노 캡슐의 제조 방법에 관한 것이다. 종래 고분자 마이셀과 리포좀과는 달리, 본 발명의 나노 캡슐은 생체 내에서 물리적 안정성을 유지 및 개선시키고, 운반 대상(예컨대, 난용성 약물 및/또는 조영제 등)을 고효율로 봉입할 수 있다. 또한 기존의 발명에서 오일 및 유기 용매를 이용하여 난용성 물질을 운반한 것과 달리, 오직 치료에 필요한 운반 대상만을 포함하여 나노캡슐을 제조할 수 있다. 따라서, 본 발명의 나노 캡슐은 주사제 제형으로 유용하게 이용할 수 있고, 난용성 약물 및/또는 조영제를 운반 대상으로 봉입하여 생체 내 약물 치료 및/또는 이미징에 이용될 수 있다.
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公开(公告)号：KR1020120036627A
公开(公告)日：2012-04-18
申请号：KR1020100098401
申请日：2010-10-08
Applicant: 한국과학기술원 , 연세대학교 산학협력단
IPC: A61L29/16 , A61L29/04 , A61M25/10 , A61K31/337
CPC classification number: A61L29/16 , A61K31/337 , A61L29/04 , A61L29/048 , A61M25/10
Abstract: PURPOSE: A chemical eluting balloon catheter multilayer-coated with chemical sealing fine particles and polymer and a method for preparing the same are provided to minimize the loss of chemical while transferring from a blood vessel to a surgical region. CONSTITUTION: A chemical eluting balloon catheter includes chemical sealing fine particles and biocompatible polymer. The fine particles and the polymer are multilayer coated on the surface of the balloon catheter. The diameters of the fine particles are less than or equal to 5um. The polymer is one or more selected from heparin, recombinant heparin, heparin derivative, heparin analogue, human serum albumin, hyaluronic acid, chitosan, alginic acid, deoxyribonucleic acid, ribonucleic acid, poly(ethylene glycol), poly(L-lactic acid), poly(glycolic acid), poly(D,L- lactic acid-co-glycolic acid), poly(carprolactone), poly(urethane), poly(amide), polymethylmethacrylate, and poly(acrylic acid). A chemical elution adjusting membrane is further coated on the uppermost layer of the multilayered coating.
Abstract translation: 目的：提供多层涂有化学密封细颗粒和聚合物的化学洗脱球囊导管及其制备方法，以便在从血管转移到外科手术区域时最小化化学物质的损失。 构成：化学洗脱球囊导管包括化学密封细颗粒和生物相容性聚合物。 细颗粒和聚合物多层涂覆在球囊导管的表面上。 细颗粒的直径小于或等于5μm。 聚合物是选自肝素，重组肝素，肝素衍生物，肝素类似物，人血清白蛋白，透明质酸，壳聚糖，海藻酸，脱氧核糖核酸，核糖核酸，聚（乙二醇），聚（L-乳酸） ，聚（乙醇酸），聚（D，L-乳酸 - 共 - 乙醇酸），聚（己内酯），聚（氨基甲酸酯），聚（酰胺），聚甲基丙烯酸甲酯和聚（丙烯酸）。 化学洗脱调节膜进一步涂覆在多层涂层的最上层。
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公开(公告)号：KR100837860B1
公开(公告)日：2008-06-13
申请号：KR1020070020496
申请日：2007-02-28
Applicant: 한국과학기술원
CPC classification number: A61K9/513 , A61K9/1075 , B82Y5/00
Abstract: Hydrophilic polymer nanocapsules are provided to encapsulate poorly soluble drugs, contrast mediums, oils, etc. stably and highly efficiently by cross-linking carious natural and synthetic hydrophilic polymers by covalent bond, and a method for preparing the hydrophilic polymer nanocapsules is provided. A method for preparing a hydrophilic polymer nanocapsule comprises the steps of: (a) dissolving a poorly soluble drug and a nonionic polymer into an organic solvent to obtain a stable oil-in-water emulsion; (b) subjecting a water phase-solubilized hydrophilic polymer to a cross-linking reaction by covalent bond on an interface of the obtained oil-in-water emulsion; and (c) evaporating a residual organic solvent to remove the residual organic solvent after performing the cross-linking reaction. The organic solvent is selected from the group consisting of methylene chloride, chloroform, 1,2-dichloroethane, cyclohexane, methyl ether ketone, butylacetate, and ethylacetate. The method further comprises the step of dissolving a contrast medium and oil into the organic solvent in the step(a). The nonionic polymer is represented by the formula A-(X)n, where A is a polymer chain that has hydrophilicity and hydrophobicity at the same time and can be solubilized into a water phase and an oil phase, X is a functional group introduced into the polymer chain A and bonded to a functional group of the hydrophilic polymer by covalent bond, and n is an integer of 2 to 1,000 as the number of the functional groups X introduced per one molecule of the polymer chain A.
Abstract translation: 提供亲水性聚合物纳米胶囊，以通过共价键交联龋齿的天然和合成的亲水性聚合物来稳定和高效地包封难溶性药物，造影剂，油等，并提供制备亲水性聚合物纳米胶囊的方法。 制备亲水性聚合物纳米胶囊的方法包括以下步骤：（a）将难溶性药物和非离子聚合物溶解在有机溶剂中以获得稳定的水包油乳液; （b）使水相溶解的亲水聚合物通过共价键在所获得的水包油乳液的界面上进行交联反应; 和（c）在进行交联反应后蒸发残留的有机溶剂以除去残留的有机溶剂。 有机溶剂选自二氯甲烷，氯仿，1,2-二氯乙烷，环己烷，甲基醚酮，乙酸丁酯和乙酸乙酯。 该方法还包括在步骤（a）中将造影剂和油溶解在有机溶剂中的步骤。 非离子聚合物由式A-（X）n表示，其中A是同时具有亲水性和疏水性的聚合物链，并且可以溶解在水相和油相中，X是引入到 聚合物链A并通过共价键与亲水性聚合物的官能团结合，并且n是每1分子聚合物链A引入的官能团X的数目，为2〜1000的整数。
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