公开(公告)号：KR100656986B1

公开(公告)日：2006-12-14

申请号：KR1020050090702

申请日：2005-09-28

Applicant: 한국과학기술원

Inventor： 박정기 ,  이성남

IPC: C08J5/10 ,  C08J5/00 ,  C08K3/04 ,  B82B3/00

Abstract: Provided is a method for preparing a novel polylactide/clay nanocomposite which is improved in shear thinning and toughness by enhancing a plasticization effect and can be applied to a biodegradable resin of polylactide. The method comprises the steps of pretreating a clay having a hydroxyl group at surface with a ring opening polymerization catalyst; adding a lactide-based monomer and a caprolactone-based monomer to the pretreated clay and increasing the reaction system to carry out the surface modification reaction of the clay; and melt mixing the obtained clay with a polylactide having a number average molecular weight of 50,000 or more to prepare a polylactide/clay nanocomposite. Preferably the ring opening polymerization catalyst is at least one organometallic catalyst of Sn, Al or rare earth elements.

Abstract translation: 本发明提供一种新型聚交酯/粘土纳米复合材料的制备方法，该新型聚交酯/粘土纳米复合材料通过增强增塑效果而改善剪切变稀和韧性，并且可以应用于聚交酯的生物可降解树脂。 该方法包括以下步骤：用开环聚合催化剂预处理表面具有羟基的粘土; 将丙交酯基单体和己内酯基单体加入到预处理粘土中并增加反应体系以进行粘土的表面改性反应; 将得到的粘土与数均分子量为50,000以上的聚丙交酯熔融混合，制备聚丙交酯/粘土纳米复合材料。 优选开环聚合催化剂是至少一种Sn，Al或稀土元素的有机金属催化剂。

公开(公告)号：KR1020030047413A

公开(公告)日：2003-06-18

申请号：KR1020010077893

申请日：2001-12-10

Applicant: 한국과학기술원

Inventor： 박정기 ,  이성남 ,  조국영 ,  성시준

IPC: A61K47/30

CPC classification number: A61K9/0024 ,  A61K38/00 ,  A61K47/10 ,  A61K47/34

Abstract: PURPOSE: An in situ implant composition is provided with a biodegradable polymer containing polyethylene glycol to prevent denaturation of the protein substance within the polymer matrix by forming the movement passage of carboxylic acid, and to control the structure and material property of the polymer by introducing polyethylene glycol. CONSTITUTION: An in situ implant composition contains a biodegradable polymer containing a copolymer of polyethylene glycol and aliphatic polyester, a solvent for dissolving the biodegradable polymer, and a medicament uniformly diffused in the solvent to mediate the biodegradable polymer. The aliphatic polyester polymer is selected from lactic acid, glycolic acid, caprolactone, dioxanone, or trimethyl carbonate. The copolymer is a graft or block copolymer.

Abstract translation: 目的：原位植入组合物提供含有聚乙二醇的可生物降解的聚合物，以通过形成羧酸的移动通道来防止聚合物基质内的蛋白质物质变性，并通过引入聚乙烯来控制聚合物的结构和材料性能 乙二醇。 构成：原位植入物组合物包含含有聚乙二醇和脂肪族聚酯的共聚物的可生物降解的聚合物，用于溶解可生物降解的聚合物的溶剂，以及均匀地扩散到溶剂中以介导可生物降解的聚合物的药物。 脂族聚酯聚合物选自乳酸，乙醇酸，己内酯，二恶烷酮或碳酸三甲酯。 共聚物是接枝或嵌段共聚物。

公开(公告)号：KR100569880B1

公开(公告)日：2006-04-11

申请号：KR1020030065269

申请日：2003-09-19

Applicant: 한국과학기술원

Inventor： 박정기 ,  이성남 ,  성시준 ,  조기윤

IPC: C08G63/06

CPC classification number: C08G65/26 ,  C08F290/062 ,  C08F290/064 ,  C08F299/02 ,  C08G63/664 ,  C08G63/912 ,  C08L71/02 ,  C08L2666/18

Abstract: 본 발명은 폴리에틸렌글리콜이 그라프트된 하기 구조식 1의 지방족폴리에스테르 및 그 제조방법을 제공한다.

상기에서, X는 지방족 에스테르 반복단위; R은 수소 또는 C
1 ∼C
5 인 알킬기; Z는 개시제 또는 연쇄이동제 부위; m/l은 0.1∼50, n은 2∼50의 양수, x는 양수로서 사용자의 필요에 따라 정해지며, y는 1∼200의 양수이다.

公开(公告)号：KR100449893B1

公开(公告)日：2004-09-22

申请号：KR1020010077893

申请日：2001-12-10

Applicant: 한국과학기술원

Inventor： 박정기 ,  이성남 ,  조국영 ,  성시준

IPC: A61K47/30

Abstract: PURPOSE: An in situ implant composition is provided with a biodegradable polymer containing polyethylene glycol to prevent denaturation of the protein substance within the polymer matrix by forming the movement passage of carboxylic acid, and to control the structure and material property of the polymer by introducing polyethylene glycol. CONSTITUTION: An in situ implant composition contains a biodegradable polymer containing a copolymer of polyethylene glycol and aliphatic polyester, a solvent for dissolving the biodegradable polymer, and a medicament uniformly diffused in the solvent to mediate the biodegradable polymer. The aliphatic polyester polymer is selected from lactic acid, glycolic acid, caprolactone, dioxanone, or trimethyl carbonate. The copolymer is a graft or block copolymer.

Abstract translation: 目的：原位植入物组合物配备有含聚乙二醇的生物可降解聚合物，以通过形成羧酸的移动通道来防止聚合物基质内蛋白质物质的变性，并通过引入聚乙烯来控制聚合物的结构和材料性质 乙二醇。 组成：原位植入物组合物含有含有聚乙二醇和脂肪族聚酯的共聚物的可生物降解聚合物，溶解可生物降解聚合物的溶剂，以及均匀分散在溶剂中介导生物可降解聚合物的药物。 脂族聚酯聚合物选自乳酸，乙醇酸，己内酯，二恶烷酮或碳酸三甲酯。 该共聚物是接枝或嵌段共聚物。

公开(公告)号：KR1020050028745A

公开(公告)日：2005-03-23

申请号：KR1020030065269

申请日：2003-09-19

Applicant: 한국과학기술원

Inventor： 박정기 ,  이성남 ,  성시준 ,  조기윤

IPC: C08G63/06

CPC classification number: C08G65/26 ,  C08F290/062 ,  C08F290/064 ,  C08F299/02 ,  C08G63/664 ,  C08G63/912 ,  C08L71/02 ,  C08L2666/18

Abstract: Provided are an aliphatic polyester grafted with polyethylene glycol having a functional group which is biodegradable and whose content of the polyethylene glycol can be controlled easily, and its preparation method. The aliphatic polyester is represented by the formula 1, wherein X is an aliphatic ester repeating unit; R is H or a C1-C5 alkyl group; Z is the moiety of an initiator or a chain transfer agent; m/l is 0.1-50; n is an integer of 2-50; x is a positive integer; and y is an integer of 1-200. Preferably X is any one selected from the group consisting of lactide, glycolide, caprolactone, beta-propiolactone, gamma-butyrolactone and p-dioxanone. The method comprises the steps of ring opening polymerizing an aliphatic ester cyclic compound and an epoxy-based monomer having a double bond at an alkyl chain terminal; and radical polymerizing the polyethylene glycol where a certain polymerizable functional group is introduced with the obtained compound.

Abstract translation: 提供了具有可生物降解的官能团的聚乙二醇接枝的脂肪族聚酯，其容易控制聚乙二醇的含量及其制备方法。 脂肪族聚酯由式1表示，其中X为脂肪族酯重复单元; R为H或C 1 -C 5烷基; Z是引发剂或链转移剂的部分; m / l为0.1-50; n为2-50的整数; x是正整数; y为1-200的整数。 优选X是选自丙交酯，乙交酯，己内酯，β-丙内酯，γ-丁内酯和对二恶烷酮中的任何一种。 该方法包括在烷基链末端开环聚合脂族酯环状化合物和具有双键的环氧基单体的步骤; 并且将所获得的化合物引入某一聚合性官能团的聚乙二醇进行自由基聚合。