公开(公告)号：KR101255520B1

公开(公告)日：2013-04-23

申请号：KR1020110110864

申请日：2011-10-28

Applicant: 한국과학기술원

Inventor： 양승만 ,  심태섭 ,  김신현 ,  허철준 ,  전환철

IPC: A61K47/48 ,  A61K47/30 ,  A61K9/16 ,  A61K9/32

CPC classification number: A61K9/5026 ,  A61K9/5031 ,  A61K9/5089

Abstract: PURPOSE: A microcapsule is provided to transfer and release a target material which is smaller than the microcapsule, and to be used as a microcarrier by using an anisotropic swelling phenomenon. CONSTITUTION: A method for preparing a microcapsule using the anisotropic swelling of a bilayer hydrogel microparticle comprises: a step of forming a hydrogel layer with a swelling property; a step of adding a polymer layer which does not swell to the formed hydrogel layer, and forming a bilayer hydrogel microparticle; and a step of forming the microcapsule by swelling the formed bilayer hydrogel microparticle. [Reference numerals] (AA) Bilayer microparticles; (BB) Hydogel layer; (CC) Polymer layer; (DD) Microcapsules;

Abstract translation: 目的：提供微胶囊以转移和释放小于微胶囊的靶材料，并通过使用各向异性溶胀现象用作微载体。 构成：使用双层水凝胶微粒的各向异性溶胀制备微胶囊的方法包括：形成具有溶胀性质的水凝胶层的步骤; 向形成的水凝胶层中添加不溶胀的聚合物层，形成双层水凝胶微粒的工序; 以及通过使形成的双层水凝胶微粒溶胀而形成微胶囊的步骤。 （附图标记）（AA）双层微粒; （BB）水凝胶层; （CC）聚合物层; （DD）微胶囊;