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公开(公告)号:KR101612906B1
公开(公告)日:2016-04-19
申请号:KR1020090067159
申请日:2009-07-23
Abstract: 본발명은피부의기능을향상시키는역학자극의스크리닝(screening) 방법으로서, (a) 피부에역학자극을반복하여가하는단계; (b) 상기역학자극에의한피부의생화학적변화를측정하는단계; 및 (c) 상기생화학적변화를기반으로피부에유용한역학자극을선정하는단계를포함한다. 본발명에따른스크리닝방법은외부자극에대한피부의생화학적변화를측정하여분석함으로써, 피부세포의기능을향상시키는생화학적변화를유도하는역학자극의종류와형태, 크기, 세기, 주기및 시간등을효율적으로스크리닝할수 있다.
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公开(公告)号:KR1020140055401A
公开(公告)日:2014-05-09
申请号:KR1020120122155
申请日:2012-10-31
Abstract: The present invention relates to a method for screening skin whitening substances, and more specifically, to a method for screening skin whitening substances comprising a step of treating a test substance on a melanin-producing cell; and a step of checking relative expression level of one or more proteins selected from a group consisting of tyrosinase, integrin alpha 6, and MITF in a cell treated with the test substance of the step.
Abstract translation: 本发明涉及一种用于筛选皮肤美白物质的方法,更具体地,涉及一种用于筛选皮肤美白物质的方法,包括在黑色素产生细胞上处理测试物质的步骤; 以及在用该步骤的测试物质处理的细胞中检查选自由酪氨酸酶,整联蛋白α6和MITF组成的组中的一种或多种蛋白质的相对表达水平的步骤。
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公开(公告)号:KR1020100010916A
公开(公告)日:2010-02-02
申请号:KR1020090067159
申请日:2009-07-23
CPC classification number: C12Q1/6883 , C12Q2600/158
Abstract: PURPOSE: A method for screening dynamic stimulation for improving skin function is provided to measure biochemical change against external stimulation and screen kind, form, size, intensity, and time of dynamic stimulation. CONSTITUTION: A method for screening dynamic stimulation for improving skin function comprises: a first step of performing repeatitive dynamic stimulation to skin; a second step of measuring biochemical change of skin by dynamic stimulation; and a third step of selecting useful dynamic stimulation based on biochemical change. The measurement is performed by measuring mRNA expression level of fibroblast-derived gene. In the third step, nerve growth factor, neurotrophin 3, TIMP 1, TrkA, TrkC, TGF alpha, TGF beta1, TGF beta2 or TGF beta3 gene is selected as dynamic stimulation.
Abstract translation: 目的:提供一种用于筛选动态刺激以改善皮肤功能的方法,以测量对外部刺激和屏幕种类,形态,大小,强度和动态刺激时间的生物化学变化。 构成:用于筛选动态刺激以改善皮肤功能的方法包括:对皮肤进行重复动态刺激的第一步骤; 通过动态刺激测量皮肤生化变化的第二步; 以及基于生物化学变化选择有用的动态刺激的第三步。 通过测量成纤维细胞衍生基因的mRNA表达水平进行测量。 在第三步中,选择神经生长因子,神经营养因子3,TIMP1,TrkA,TrkC,TGFα,TGFβ1,TGFβ2或TGFβ3基因作为动态刺激。
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