公开(公告)号：KR100804720B1

公开(公告)日：2008-02-18

申请号：KR1020060091376

申请日：2006-09-20

Applicant: 한국식품연구원

Inventor： 권대영 ,  김현표 ,  허문영

IPC: A61K36/48 ,  A61P11/06 ,  A61P37/08

CPC classification number: A61K36/48 ,  A23L11/09 ,  A23V2200/304 ,  A23V2200/314 ,  A61K2236/331 ,  A61K2236/333 ,  Y10S514/826

Abstract: A composition comprising an extract of Chungkukjang(Korean soup prepared with fermented soybeans) is provided to be able to inhibit 5-lipoxygenase and show the eosinophilic effusion inhibitory effect in an asthma animal model induced by ovalbumin, thereby being usefully used as an anti-asthmatic and anti-allergic composition. A pharmaceutical composition for preventing and treating asthma and allergic diseases comprises an extract of Chungkukjang as an effective ingredient, where the extract is a crude extract, an extract soluble in water, methanol, ethanol, butanol, or a mixture solvent thereof, or an extract soluble in hexane, chloroform or ethylacetate of the Chungkukjang, and the allergic disease is bronchial asthma, allergic rhinitis, allergic asthma, or allergic dermatitis. A health functional food for preventing and improving the asthma and the allergic diseases comprises the extract of Chungkukjang and is in the form of powder, granule, tablet, capsule or drink.

Abstract translation: 提供了包含中枢神经提取物（用发酵大豆制备的韩国汤）的组合物，以能够抑制5-脂氧合酶，并且在由卵白蛋白诱导的哮喘动物模型中显示嗜酸性渗出抑制作用，从而有效地用作抗哮喘 和抗过敏组合物。 用于预防和治疗哮喘和变应性疾病的药物组合物包括中枢珠提取物作为有效成分，其中提取物是粗提物，可溶于水，甲醇，乙醇，丁醇或其混合溶剂的提取物，或提取物 可溶于中心的己烷，氯仿或乙酸乙酯，过敏性疾病为支气管哮喘，过敏性鼻炎，过敏性哮喘或过敏性皮炎。 一种用于预防和改善哮喘和过敏性疾病的健康功能食品包括中枢珠提取物，呈粉末，颗粒，片剂，胶囊或饮料的形式。

公开(公告)号：KR100850443B1

公开(公告)日：2008-08-07

申请号：KR1020070031569

申请日：2007-03-30

Applicant: 한국식품연구원

Inventor： 권대영 ,  김현표 ,  허문영

IPC: A23L1/202 ,  A23L1/29 ,  A23L1/30

CPC classification number: A23L11/09 ,  A23L3/40 ,  A23L29/065 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/108

Abstract: A preparation method of deffated Cheonggukjang, and a composition containing the extract of the defatted Cheonggukjang as an effective ingredient are provided to inhibit inflammatory diseases such as rheumatoid arthritis and remarkably reduce the calorie value of Cheonggukjang by using a nonpolar solvent. A preparation method of defatted Cheonggukjang comprises the steps of: (i) washing soybeans; (ii) soaking the washed soybeans in water in a volume ratio of 1:3~5 at 4~30°C for 12~24hr; (iii) dehydrating the soaked soybeans for 10min~2hr; (iv) steaming the dehydrated soybeans by a pressure-steamer at 100~150°C for 15~30min; (v) cooling the steamed soybeans to 50~70°C; (vi) inoculating the cooled soybeans with 2wt% of Bacillus subtilis SNU816, based on the weight of the soybeans; (vii) fermenting the inoculated soybeans for 72hr to obtain raw Cheonggukjang; (viii) lyophilizing/powdering the raw Cheonggukjang; (ix) mixing the powdered Cheonggukjang with a solvent such as nucleic acid, ether, or ethylacetate in a mix ratio of 1:8~15; (x) keeping the mixture for 2~4days; and (xi) removing the solvent from the mixture, and then drying it at room temperature. A composition for the prevention/treatment of inflammation-related diseases contains 0.1~50wt% of the extract of the defatted Cheonggukjang, based on the total weight of the composition.

Abstract translation: 提供了一种封闭的Cheonggukjang的制备方法以及含有脱脂Cheonggukjang提取物作为有效成分的组合物，以抑制类风湿性关节炎等炎症性疾病，并通过使用非极性溶剂显着降低Cheunggukjang的卡路里值。 脱脂清肝汤的制备方法包括：（i）洗涤大豆; （ii）在4〜30℃下将洗涤后的大豆以1：3〜5的体积比浸泡12〜24小时; （iii）将浸泡的大豆脱水10分钟〜2小时; （iv）通过压力蒸笼在100〜150℃下蒸煮脱水大豆15〜30分钟; （v）将蒸黄豆冷却至50〜70℃; （vi）基于大豆的重量，将2重量％的枯草芽孢杆菌SNU816的冷却大豆接种; （vii）将接种的大豆发酵72小时，以获得未加工的Cheonggukjang; （viii）冷冻/粉碎原料长江口; （ix）将粉末状澄清焦粉与溶剂如核酸，乙醚或乙酸乙酯以1:8〜15的混合比混合; （x）保持混合物2〜4天; 和（xi）从混合物中除去溶剂，然后在室温下干燥。 基于组合物的总重量，用于预防/治疗炎症相关疾病的组合物含有0.1〜50重量％的脱脂Cheonggukjang提取物。